Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative reviewReview Published on 2022-03-302023-06-15 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, [키워드] combination therapy COVID-19 infection Cytokine storm doxycycline Ivermectin SARS-CoV-2 [DOI] 10.1016/j.jiph.2022.03.014 PMC 바로가기 [Article Type] Review
Ivermectin for the Treatment of Coronavirus Disease 2019: A Systematic Review and Meta-analysis of Randomized Controlled Trials코로나바이러스 질병 2019 치료를 위한 이버멕틴: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-03-232022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 임상, [키워드] 95% confidence interval Adult patients adverse event adverse events AEs all-cause mortality all-cause mortality rate all-cause mortality rates benefit Bia confidence interval Control control group control groups Controlled coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity did not reduce Effect evaluated Evidence Hospital stay inverse Ivermectin LOS main analyses mean difference meta-analyses Meta-analysis Mild moderate Mortality mortality rates outcome outcomes Patient patients with COVID-19 performed Placebo Primary outcomes random effect Randomized controlled trial Randomized controlled trials RCT RCTs reduced Relative risk review risk risk of bia RoB SAE SAEs SARS-CoV-2 searched secondary Secondary outcomes severe AE severe AEs severity of COVID-19 Standard of care subgroups treat viral clearance [DOI] 10.1093/cid/ciab591 PMC 바로가기 [Article Type] Meta-Analysis
Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposingSARS-COV-2 감염 및 약물 용도에 영향을 미치는 기능, 경로 및 조절제를 강조하는 숙주 게놈 바이오 마커의 계산 식별Article Published on 2022-03-112022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 신약개발, 치료제, [키워드] 3CL Analysis analyzed binding affinities Biomarker candidate drugs Computational biology and bioinformatics control sample COVID-19 CXCL2 daclatasvir DEGs differentially expressed gene docking drug Drug discovery drug target drugs Economy effective enrichment analysis FDA approved Drugs function functional functions genomic GUCY1A2 highlighting Host hub-genes identify IGF2 independent indicate infections Interaction investigated IRF7 Ivermectin KEGG pathway KLF6 life miRNA miRNAs molecular docking analysis NEDD9 network analysis PAG1 pandemic pathway Pathways performed PPI Protein Protein–protein interaction Proteins Radotinib Rapamycin receptor receptor protein receptor proteins receptors reduced RNA sequence SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Seven signaling pathway signaling pathways significantly SNRPD2 stability Stat1 Systems biology tacrolimus the SARS-CoV-2 Thiostrepton TLR2 transcriptomics Treatment USP53 vaccination variants of SARS-CoV-2 ZFP36 [DOI] 10.1038/s41598-022-08073-8 PMC 바로가기 [Article Type] Article
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes게놈 전반에 걸친 분석을 통해 SARS-CoV-2 바이러스 유전자 Orf9c가 인간 다능성 줄기 세포 유래 심근세포에 미치는 해로운 영향을 보여줍니다Article Published on 2022-03-082022-09-11 Journal: Stem Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] Abnormalities abnormality acute respiratory syndrome acute respiratory syndrome coronavirus ameliorated analyses Analysis Apoptosis apoptotic approved ATP ATP synthesis cardiac dysfunction cardiac injury cardiomyocyte caused Cell cellular characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death defined detrimental detrimental effect detrimental effects disease down-regulated drug Drug administration dysfunction electrical ENCODE expression Factor Factors food functional Genes Genome heart disease heart muscle human pluripotent stem cell Impact Inflammation Injury Ivermectin manifestation Manifestations meclizine meclizine. molecular mechanism molecular mechanisms Orf9c overexpression Pathways Protein Proteins Proteomic analysis reduced respiratory restored SARS-CoV-2 SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly stem cell Therapeutic approach Transcriptomic analyses transcriptomic analysis U.S. Food and Drug Administration up-regulated [DOI] 10.1016/j.stemcr.2022.01.014 PMC 바로가기 [Article Type] Article
Oral susceptibility to ivermectin is over fifty times greater in a wild population of Anopheles albimanus mosquitoes from Belize than the STECLA laboratory reference strain of this mosquito벨리즈의 야생 Anopheles albimanus 모기 집단에서 이 모기의 STECLA 실험실 기준주보다 이버맥틴에 대한 경구 감수성이 50배 이상 높습니다.Research Published on 2022-03-042024-08-01 Journal: Malaria Journal [Category] 말라리아, [키워드] Anopheles albimanus Belize Ivermectin STECLA [DOI] 10.1186/s12936-022-04092-y PMC 바로가기 [Article Type] Research
Mortality and associated risk factors in patients hospitalized due to COVID-19 in a Peruvian reference hospitalResearch Article Published on 2022-03-022022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95%CI Adjusted analysis adjusted hazard ratio Admission age alteration biochemical Clinical characteristics Cohort cohort study Comorbidity Corticosteroid COVID-19 Cox regression model determine dose evaluate Factors general condition hematological high mortality hospital Hospitalization Hospitalized hypertension in-hospital mortality independent variable IQR Ivermectin laboratory result leukocyte lower mortality lower oxygen saturation male median medical record moderate Mortality mortality rate National obesity objective outcomes oxygen saturation patients patients hospitalized patients with COVID-19 Physical examination Result risk factor Sociodemographic Treatment type 2 diabete use of corticosteroid use of hydroxychloroquine was used [DOI] 10.1371/journal.pone.0264789 PMC 바로가기 [Article Type] Research Article
Broadening the range of use cases for ivermectin – a review of the evidenceArticle Published on 2022-03-022024-08-28 Journal: Nature Food [Category] 말라리아, [키워드] Ivermectin malaria Mass drug administration neglected tropical diseases soil-transmitted helminths
Comparison of Trials Using Ivermectin for COVID-19 Between Regions With High and Low Prevalence of Strongyloidiasis: A Meta-analysis스트롱길로이드증의 유병률이 높은 지역과 낮은 지역 간의 COVID-19에 Ivermectin을 사용한 시험의 비교: 메타 분석Meta-Analysis Published on 2022-03-012022-09-11 Journal: JAMA Network Open [Category] 임상, 치료제, [키워드] 95% CI Analysis association Characteristics claimed clinical trial clinical trials correlation coefficient COVID-19 data extraction database decrease difference effect sizes effective Endemic estimate evaluate Evidence explained group heterogeneity Hypothesis increase in interact Interaction Interpretation item Ivermectin Meta-analysis meta-regression Mortality original outcome Patient patients patients with COVID-19 Prevalence random-effect Random-effects meta-analysis randomization randomized clinical trial randomized clinical trials Region Relative risk Reporting review risk RR of mortality significant difference significantly statistically significant strongyloidiasis synthesis systematic reviews Testing took place Treatment treatment for COVID-19 Trial Variability variance were excluded [DOI] 10.1001/jamanetworkopen.2022.3079 PMC 바로가기 [Article Type] Meta-Analysis
Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2렘데시비르-이버멕틴 조합은 SARS-CoV-2에 대한 개선된 시험관 내 활성과 상승적인 상호작용을 나타냅니다Article Published on 2022-03-012022-09-11 Journal: International journal of antimicrobial agents [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral activity approved Combination combination therapy combination treatment coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 CPE Cytopathic activity demonstrated drug Drug administration drug resistance effective Efficacy food greater in vitro in vitro activity in vivo Interaction Ivermectin management mechanism offer reduce Remdesivir reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Support synergistic synergistic action synergy therapeutic therapeutic index to define Treatment strategies US Food and Drug Administration [DOI] 10.1016/j.ijantimicag.2022.106542 PMC 바로가기 [Article Type] Article
Coronavirus disease 2019 on routine testing in eclampsia: a case reportCase Report Published on 2022-03-012022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, MERS, SARS, [키워드] Administered Admission amenorrhea amniotic blood pressure breath Case report changes Chest radiograph clinical feature Contact coronavirus disease Coronavirus disease 2019 cough Course COVID COVID-19 Diagnosis discharge discharged distress eclampsia elevated female fetal fluid overload Headaches interstitial intravenous Ivermectin Leukocytosis liver enzymes Loading dose maintenance dose male membranes mother Nasopharyngeal swab Newborn outcomes overlapping oxygen saturation Patient polymerase chain positive preeclampsia Pregnancy pregnant women presenting Rapid test routine Routine testing rupture Seizures Tablet Tachycardia tachypnea tested Treatment Urine vaginal delivery Vitamin C [DOI] 10.1186/s13256-022-03308-8 PMC 바로가기 [Article Type] Case Report