A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients회복기 COVID-19 고형장기 이식 수혜자의 장기 SARS-CoV-2 특이 적응 면역 기억에 대한 종합적인 평가Article Published on 2022-05-012022-09-11 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adaptive Adaptive immunity Asymptomatic Clinical severity controls convalescent convalescent patient Convalescent patients COVID-19 COVID-19 infection COVID-19 severity cytokine detectable determined by driven by eight ELISA IFN-γ IFN-γ producing T cells IL-2 IL12 immune immune memory individual individuals Infection kidney liver long-lasting lung memory B cell memory B cells memory response Mild organ transplantation Patient performed producing recipient reported response SARS-CoV-2 SARS-COV-2 infection serological seropositive severity significantly Solid solid organ solid organ transplant solid organ transplantation solid organ transplants T cells Transplant transplantation while [DOI] 10.1016/j.kint.2021.12.029 PMC 바로가기 [Article Type] Article
COVID-19 in dialysis: clinical impact, immune response, prevention, and treatment투석에서의 코로나19: 임상적 영향, 면역 반응, 예방 및 치료Review Published on 2022-05-012022-09-11 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료법, [키워드] absence adenoviral vector vaccine adverse effect antibody antibody levels BNT162b2 BNT162b2 vaccine booster dose candidate Candidates Care clinical impact Course COVID-19 COVID-19 pandemic develop dialysis disease severity dose Evidence Hemodialysis Hospitalization humoral immune response immune Immune escape immune response immune responses Immunity immunogenicity increase increased risk Infection initial long-lasting monoclonal antibody Mortality mRNA mRNA vaccines mRNA-1273 mRNA-1273 vaccine neutralizing monoclonal antibodies Patient Preliminary data prolonged viral shedding Prophylaxis PROTECT Psychological distress Reinfection responses reveal robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 variant SARS-CoV-2 variants severe disease significantly survivor Therapeutic strategies therapeutic strategy Treatment vaccination vaccine response Viral viral shedding virtue [DOI] 10.1016/j.kint.2022.01.022 PMC 바로가기 [Article Type] Review
Nutritional Modulation of Gut Microbiota Alleviates Severe Gastrointestinal Symptoms in a Patient with Post-Acute COVID-19 Syndrome장내 미생물총의 영양 조절은 급성 COVID-19 증후군 환자의 심각한 위장 증상을 완화합니다Case Reports Published on 2022-04-262022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] 16S rRNA 16S rRNA gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate alleviation alleviation of symptoms Anxiety Appetite arising ASV Bacteria baseline Care Case report change coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pandemic COVID-19-related symptom COVID-19-related symptoms defined dosage Dysbiosis Expanded access fatty Fatty acid feasibility Gastrointestinal Gastrointestinal symptom gastrointestinal symptoms Gut gut microbiota Health IMPROVE in sight increase increase in IND indicate Infection insulin Intervention life long-hauler. long-lasting loss of appetite medication microbial microbiota modulating modulation nausea nutritional intervention palpitation Patient patient population patients with COVID-19 problem provided public health Quality of life reduce reduced rRNA SARS-CoV-2 SARS-CoV-2 detection sequence serum sight Significant significantly small intestine Symptom symptom severity syndrome target the patient variant [DOI] 10.1128/mbio.03801-21 PMC 바로가기 [Article Type] Case Reports
Generation and persistence of S1 IgG and neutralizing antibodies in post-COVID-19 patients코로나19 이후 환자의 S1 IgG 및 중화항체 생성 및 지속Article Published on 2022-04-012022-09-12 Journal: Infection [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age antibody Antibody Response Asymptomatic COVID-19 ELISA exponential decay model Gender Generation greater groups highest IgG antibody immune response Immunity Infection Logistic long-lasting male Model NAb NAbs Neutralizing antibodies neutralizing antibody no statistical difference Older other coronaviruses participants with SARS-CoV-2 persistence post-COVID-19 patient Post-infection Region Reinfection S1 IgG SARS-CoV-2 SARS-COV-2 infection severity severity of COVID-19 the disease the S1 subunit variables was used [DOI] 10.1007/s15010-021-01705-7 PMC 바로가기 [Article Type] Article
Cellular and Humoral Immune Responses and Breakthrough Infections After Two Doses of BNT162b Vaccine in Healthcare Workers (HW) 180 Days After the Second Vaccine Dose두 번째 백신 접종 후 180일 동안 의료 종사자(HW)에서 BNT162b 백신 2회 접종 후 세포 및 체액 면역 반응 및 돌발 감염Article Published on 2022-03-312022-09-12 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, [키워드] age all subject binding antibody BNT162b Breakthrough infection Cytopathic effect Day Delta VOC Dilution domain enrolled evaluated groups healthcare Healthcare workers highest Hospitalization human serum humoral Humoral response identify IFN-γ IgG IgG level IgG levels IgG titer Immunity individuals Infection information Live virus long-lasting maintain microneutralization mRNA vaccine mRNA vaccines neutralized neutralizing antibody Neutralizing antibody titer neutralizing responses Neutralizing titer Older Predictive protective immunity Protein remained response SARS-CoV-2 second secretion shown stages subject subjects T-cell Response tested threshold Vaccine virus Volume was determined worker Wuhan strain [DOI] 10.3389/fpubh.2022.847384 PMC 바로가기 [Article Type] Article
Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers장기간 코로나바이러스를 가진 개인의 스페인 코호트에서 지속되는 과민성 세포독성 면역 반응: 진단 바이오마커의 식별Article Published on 2022-03-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Accuracy Algorithm analyzed Antiviral Autoimmune disease Blood blood type caused CD3 CD4 CD56 CD57 CD8 CD8+ CD8+ T cells cells characterized chest pain clinical feature Clinical management Cohort cytotoxic cytotoxic activity cytotoxic immune response Definition demographic factor Demographic factors detect diagnostic biomarker Diagnostic biomarkers expression female gender forest functional hypotheses identification immune immune exhaustion. immune parameter immunological parameter immunological parameters IMPROVE individual Infection Inflammatory response lethargy Long long-COVID long-lasting Lymphocytes marker mechanism memory cell Memory cells NK cell NK cells organ participant patients PD-1 persistence persistent phenotype pleuritic Population Post-infection predicted Random forest Random Forest algorithm recovered completely response SARS-CoV-2 significantly increased Signs and symptoms Spanish supported sustained Symptom symptoms of COVID-19 syndrome T cells T lymphocytes Temra cells tissue Treg Tregs [DOI] 10.3389/fimmu.2022.848886 PMC 바로가기 [Article Type] Article
Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22)비강 나노바디(Nb22)에 의해 부여된 hACE2 마우스의 SARS-CoV-2에 대한 단기 순간 예방 및 효율적인 치료Article Published on 2022-03-172022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] addition Administered Against alpaca binding blocked Breakthrough infection breakthrough infections caused circulating Community Complete COVID-19 vaccine current Delta delta variant demonstrated doses effective Efficacy efficient exhibited exhibiting hACE2 highlight immunized Inhaled inoculation instantaneous instantaneous prophylaxis instantaneous protection intranasal long-lasting nanobodies nanobody Nb22 neutralization PrEP Prophylaxis RBD reported respiratory Respiratory system SARS-CoV-2 Seven single dose Spike protein stability STIP Structural analysis Structure the spike protein therapeutic unmet need variants [DOI] 10.3389/fimmu.2022.865401 PMC 바로가기 [Article Type] Article
Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of ConcernCOVID-19 회복기의 면역 반응에 대한 종단적 추적은 우려의 다른 SARS-CoV-2 변종에 대한 오미크론 및 시차 손상에 대한 중화 활성의 부재를 나타냅니다Article Published on 2022-03-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] activity Against Alpha alpha and delta variants analyzed antibodies association B cell B cells Beta cellular immunity cellular response Cellular responses changes in clearance Cohort concern Correlation analysis COVID-19 decrease Delta Delta variants Evaluating flow cytometry Gamma humoral humoral and cellular immunity humoral immune response IgG antibody IgG titer immune Immunity indicate indicated individual investigated lack long-lasting longitudinal memory memory B cell memory B cells neutralization capacity neutralization test Neutralizing antibodies neutralizing antibody omicron Omicron variants Other Patient patients persistence Perturbation phenotype Prospective Study protection Protective response SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 variant SARS-CoV-2 variants sera spike Spike-specific memory B cells surrogate virus neutralization test the disease variant variants variants of concern Viral virus neutralization test was measured Wuhan strain [DOI] 10.3389/fimmu.2022.863039 PMC 바로가기 [Article Type] Article
Changes in work and health of Australians during the COVID-19 pandemic: a longitudinal cohort studyArticle Published on 2022-03-122022-10-04 Journal: BMC Public Health [Category] 임상, [키워드] addition association Australian baseline being benefit change changes in clinical contributing to COVID-19 COVID-19 pandemic declined described early stage Effect Effects employment Engagement examined form greater Health improvement lockdown long-lasting longitudinal longitudinal cohort study Longitudinal studies loss of work Mental mental health New occupational health outcome pandemic participant physical physical activity protective role Psychological distress public health measure reduce Regression model returned Support sustained Viral transmission work [DOI] 10.1186/s12889-022-12897-4 PMC 바로가기 [Article Type] Article
Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2차세대 COVID-19 백신의 호흡기 점막 전달은 SARS-CoV-2의 조상 및 변이 균주 모두에 대해 강력한 보호를 제공합니다Article Published on 2022-03-032022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] adenoviral vector adenoviral vectors Administered animal models antibody Antigen B.1.1.7 B.1.351 chimpanzee adenoviral vector COVID-19 COVID-19 vaccine develop effective Effectiveness evaluated expressing human adenoviral vector humoral Humoral immunity Immunity immunization induce Innate immunity intramuscular intramuscular immunization intramuscularly intranasal Local long-lasting memory T cell memory T cells mucosal multi-valent vaccine multivalent vaccine murine models next-generation vaccines nucleocapsid protective immunity provide RdRP respiratory respiratory mucosal immunity respiratory mucosal immunization responses robust SARS-CoV-2 SARS-CoV-2 variant Single-dose Spike protein strain T cell T cell immunity T cells the spike protein trained innate immunity trivalent Vaccine variant variants variants of concern VoC VOCs [DOI] 10.1016/j.cell.2022.02.005 PMC 바로가기 [Article Type] Article