Medical Research Council – Page 7 – Communicable Diseases Research

Favorable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

자가면역 류마티스 질환이 있는 소아 및 청소년의 인간 코로나바이러스에 대한 유리한 항체 반응

Clinical and Translational Article

Published on 2021-08-142022-09-14
Journal: Med (New York, N.Y.) [Category] MERS, SARS, 임상, 진단,

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study

Articles

Published on 2021-08-012022-10-31
Journal: The Lancet. Microbe [Category] COVID-19, MERS, SARS,

[키워드] Admission Against age analysed antimicrobial available data Bacterial infection bloodstream carbapenem case report form caused CCP-UK characterisation clinical clinically Co-infection collected Community concerning conducted Critical care Culture demographic Department development diagnosed eligible England Enterobacteriaceae Escherichia coli European excluded female finding for inclusion foundation Frequency funding Haemophilus influenzae highest hospital Hospital admission hospitalised Imperial College London Infection Inpatient Intervention IQR ISARIC ISARIC WHO CCP-UK Laboratory likelihood median Medical Research Council Melinda Gate microbiologically multicentre NIHR NIHR HPRU organism outcome pandemic pathogen Pathogens Patient patients patients with COVID-19 predominant prospective cohort study protection recorded respiratory SARS-COV-2 infection SARS-CoV-2 test Secondary infection secondary infections secondary respiratory infections Staphylococcus aureus target therapeutic unit University of Liverpool Wellcome Trust were excluded were recorded WHO with COVID-19
[DOI] 10.1016/S2666-5247(21)00090-2 PMC 바로가기 [Article Type] Articles

Intense and Mild First Epidemic Wave of Coronavirus Disease, The Gambia

Research

Published on 2021-08-012022-10-31
Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS,

Changing composition of SARS-CoV-2 lineages and rise of Delta variant in England

Research Paper

Published on 2021-07-312022-10-31
Journal: EClinicalMedicine [Category] COVID-19,

[키워드] Academy B.1.1.7 B.1.617.2 Cancer Research UK Changing college Community community transmission concern COVID-19 cross-sectional DeepMind Delta delta variant dominant dominant lineage dominant variant driven by effort England English Epidemiology Europe Factor finding foundation Fund funding Gate genomic Genomic surveillance Immune escape Immunity Infection information Interaction intrinsic Lineage London Medical Research Council Medical Science Medicine MRC Mutation NHS non-B.1.1.7 variant outcome PCR Prevalence public health Region SARS-CoV-2 SARS-CoV-2 lineage specificity Spread study period Surveillance the SARS-CoV-2 thought trajectory Transmissibility Trust understanding variant variants of concern variety VoC Waste water monitoring Wellcome Sanger Institute WHO
[DOI] 10.1016/j.eclinm.2021.101064 PMC 바로가기 [Article Type] Research Paper

Early detection of COVID-19 in the UK using self-reported symptoms: a large-scale, prospective, epidemiological surveillance study

자가 보고 증상을 이용한 영국의 COVID-19 조기 발견: 대규모, 전향적, 역학 감시 연구

Observational Study

Published on 2021-07-292022-09-10
Journal: International Journal of Environmental Research an [Category] SARS, 임상, 치료기술,

[키워드] age Algorithm artificial intelligence AUC body-mass body-mass index changes in characteristic chronic chronic disease clinical information Comorbidities Council COVID-19 COVID-19 pandemic COVID-19 PCR test COVID-19 symptoms Department detect Early detection Engineering epidemiological epidemiological surveillance evaluated feasible feature finding foci foundation funding health-care heart Hierarchical identify individual infected with SARS-CoV-2 Infection Logistic regression logistic regression model Massachusett Medical Research Council Medical resources mobile phone Model National Health Service NHS Older pandemic participant Participants PCR test populations predict Probability readiness receiver operating characteristic receiver operating characteristic curve reported symptom robust SARS-COV-2 infection Science Self-isolation self-reported symptom Self-reported symptoms sensitivity Sex significantly higher Society specificity spread of COVID-19 stratified study population subgroup subgroups Surveillance Symptom Symptoms symptoms onset test results training set variable Wellcome Trust
[DOI] 10.1016/S2589-7500(21)00131-X PMC 바로가기 [Article Type] Observational Study

Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: A cohort study in UK Biobank

더 짧은 백혈구 텔로미어 길이는 부정적인 COVID-19 결과와 관련이 있습니다: UK Biobank의 코호트 연구

Research Paper

Published on 2021-07-232022-09-11
Journal: EBioMedicine [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] 95% CI adjusted age Analysis association Biological Biotechnology Causality cohort study collider bias Community Composite conducted coronavirus coronavirus disease Coronavirus disease-19 Council COVID-19 Critical care defined determine Ethnicity evaluate exploratory finding foundation funding genetic variants heart higher risk Hospital admission independent independent of infection with SARS-CoV-2 information leucocyte leukocyte marker Medical Research Council Mortality MR analyses Odds ratio outcome outcomes participant positive randomisation recorded recruited reduced reflect respiratory Respiratory Support risk risk factor Science Sex tested UK biobank UKB with COVID-19
[DOI] 10.1016/j.ebiom.2021.103485 PMC 바로가기 [Article Type] Research Paper

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study

Articles

Published on 2021-07-172022-10-04
Journal: Lancet (London, England) [Category] Fulltext, SARS, 유전자 메커니즘,

[키워드] addition Adult patient age association cardiovascular Care clinical Cohort cohort study Comorbidities Comorbidity complex Complication consequence COVID-19 COVID-19 complication COVID-19 complications COVID-19 illness COVID-19 pandemic defined diagnose discharge disease females finding functional funding hallmark Health health-care health-care system healthy individuals help hospital in-hospital complication in-hospital complications incidence ISARIC liver Logistic regression male management Medical Research Council multicentre neurological Neurological complication Older organ-specific outcome outcomes Patient patients patients with COVID-19 Primary outcome reduced reported respiratory SARS-COV-2 infection self-care survival the patient WHO with COVID-19
[DOI] 10.1016/S0140-6736(21)00799-6 PMC 바로가기 [Article Type] Articles

Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world

Research Article

Published on 2021-07-132022-10-31
Journal: eLife [Category] COVID-19, SARS,

[키워드] activity Alliance ART authors BAL Cambridge center children Clinical research country Coverage Dame Data analysis data interpretation death Department development disease Diseases effective Fever Final foundation funding group had no Haemophilus influenzae hepatitis B human papillomavirus Impact Imperial College London Japanese encephalitis Johns Hopkins University LMICs London mathematical Mathematical modelling Medical Research Council Medicine Melinda Gate MRC Neisseria meningitidis occur Other Oxford pathogen Pennsylvania State University provide Public Health England Public health interventions receive Richard School Science Singapore Streptococcus pneumoniae Study design Support supported Travel unit university vaccination Vaccine Vaccine impact virus was used Washington
[DOI] 10.7554/eLife.67635 PMC 바로가기 [Article Type] Research Article

Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time

커뮤니티 SARS-CoV-2 사례의 바이러스 부하에 대한 프록시인 Ct 역치 값은 인구 및 시간 경과에 따라 광범위한 변화를 보여줍니다

Research Article

Published on 2021-07-122022-09-10
Journal: eLife [Category] SARS, 진단, 치료기술,

[키워드] age antibody antibody tests changed Community COVID-19 Infection Survey Ct threshold Ct value Ct values cycle threshold declining Department Effect epidemiological Ethnicity family foundation funding Genes IgG independent predictors investigated IQR median Medical Research Council Medical Research Council UK National nose nose and throat ORF1ab Other participant Population positive predictor RT-PCR SARS-CoV-2 SARS-CoV-2 positivity self-reported symptom Self-reported symptoms Sex significantly higher Surveillance Swab swabs Symptoms tested throat swabs UK’s national COVID-19 Infection Survey Variation Viral Viral load Wellcome Trust without symptoms
[DOI] 10.7554/eLife.64683 PMC 바로가기 [Article Type] Research Article

Temporal trends and forecasting of COVID-19 hospitalisations and deaths in Scotland using a national real-time patient-level data platform: a statistical modelling study

Articles

Published on 2021-07-052022-10-31
Journal: International Journal of Environmental Research an [Category] COVID-19, MERS,

[키워드] 95% CI 95% prediction interval age assessment association Care challenge Characteristics clinical risk Clinical risk factors Cohort Comorbidities Comorbidity COVID-19 COVID-19 hospitalisation COVID-19 pandemic COVID-19-related death Cox proportional hazard dataset death death rate death rates develop disease distribution epidemiological finding funding group hazard ratio highest Hospital admission hospitalisation hospitalisations identify incidence individual Industrial Innovation Male sex Medical Research Council MONITOR morbidity and mortality National Older age Patient per day platform positive Positive test predict primary care Probability proportion provided public health recorded reduce Registered representing required resource risk Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RT-PCR Scottish second wave Sex statistical Strategy stratified Surveillance survival technology Temporal tested unique was used were used
[DOI] 10.1016/S2589-7500(21)00105-9 PMC 바로가기 [Article Type] Articles