Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis중증 COVID-19 환자의 입원 시 아미노산 대사가 크게 변경됨: 종단 표적 대사체학 분석 결과Observation Published on 2021-12-082022-09-10 Journal: Microbiology Spectrum [Category] SARS, 바이오마커, [키워드] acid acute phase addition Altered approach arginine biomarker signature Care citrulline clinical manifestation clinical manifestations Clinical severity complement complementary Course COVID-19 COVID-19 case COVID-19 cases COVID-19 patient COVID-19 patients Defense defense mechanisms Deprivation described disease Disease progression disease stage effective evaluate Evidence evidence of finding fluctuation fluctuations followed by functional Glutamine heterogeneity highlight hospitalized patient Host host defense immune response immune responses Infection inhibited knowledge Kynurenine list longitudinal longitudinal study M2 macrophage polarization Macrophage marker mechanism metabolic pathway metabolic pathways metabolism metabolite metabolites metabolomic metabolomic profiling metabolomic signature metabolomics molecular molecular mechanism molecular mechanisms ornithine outcome Pathogenesis pathogenesis of COVID-19 pathway Pathways Patient Phenylalanine profile SARS-CoV-2 SARS-COV-2 infection serum serum sample serum samples severity the disease time Tryptophan tyrosine Virus-host interactions [DOI] 10.1128/spectrum.00338-21 PMC 바로가기 [Article Type] Observation
Nordic Walking Rather Than High Intensity Interval Training Reduced Myostatin Concentration More Effectively in Elderly Subjects and the Range of This Drop Was Modified by Metabolites of Vitamin DArticle Published on 2021-12-082022-10-31 Journal: Nutrients [Category] Coronavirus, SARS, [키워드] 24,25(OH)2D3 25(OH)D3 3-epi-25(OH)D3 accompanied age aging assigned baseline blood sample Body caused change changes Concentration conducted Consequences COVID-19 pandemic decorin dependent on drop Effect elderly exacerbated examined form induce intensity interval metabolite metabolites myokines myostatin osteokines performed physical activity protocol Range Self-isolation significant decrease significant negative correlation subsequent training Vitamin D walking [DOI] 10.3390/nu13124393 PMC 바로가기 [Article Type] Article
Increased Kynurenine Indicates a Fatal Course of COVID-19Article Published on 2021-12-072022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] accompanied activated age Analysis basic Biomarker Blood C-reactive protein Clinical characteristics Cohort contribute Course COVID-19 COVID-19 patients Cox regression analysis creatinine CRP cut off database death Deceased diabetes diagnosis of SARS-CoV-2 disease ferritin fibrinogen first positive function hazard ratio highest hospital hospitalized COVID-19 patient hypertension IL-6 immune response Increased increased risk inefficient Infection inflammatory reaction interleukin-6 involved Kaplan-Meier analysis Kynurenine Laboratory laboratory data limit metabolites Mortality N-terminal obesity observation outcome Patient patients died peptide predict Protein protein S Prothrombin time renal Result ROC analysis SARS-CoV-2 SARS-CoV-2 patient sensitivity severe COVID-19 significantly higher specificity survival survived telomere TRP Tryptophan university variable were recorded [DOI] 10.3390/antiox10121960 PMC 바로가기 [Article Type] Article
Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patientsArticle Published on 2021-12-032022-10-04 Journal: Scientific Reports [Category] 신약개발, 임상, 치료법, 치료제, [키워드] 95% CI 95% confidence interval acute respiratory distress association Biochemistry Computational biology and bioinformatics COVID-19 COVID-19 patient decrease Drug discovery Electronic health record Endocrine endocrinology Evidence hazard hazard ratio Health Hospitalization Hospitalized Kaplan–Meier survival curve metabolite metabolites Mortality mortality rate Patient patient survival patients Population Ratio retrospective cohort Risk factors severity of COVID-19 suggested Support survival syndrome were recorded [DOI] 10.1038/s41598-021-02701-5 PMC 바로가기 [Article Type] Article
Longitudinal Metabolomics Reveals Ornithine Cycle Dysregulation Correlates With Inflammation and Coagulation in COVID-19 Severe PatientsMicrobiology Published on 2021-12-032022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] amino acid metabolism amino acids analyzed association biochemical Biochemical parameters Blood change Coagulation correlated COVID-19 COVID-19 patient COVID-19 patients creating cycle cytokine Cytokines diagnostic dipeptides discharge Disease progression drug dysregulation FIVE global pandemic humans Inflammation longitudinal longitudinal change marker metabolic disorder metabolic factor metabolite metabolites metabolome metabolomic metabolomics Mild nine ornithine ornithine cycle pathogenic mechanisms pathogenicity peptides potential mechanism provided SARS-CoV-2 SARS-COV-2 infection serum severe disease Severe patient severe patients significantly significantly higher valuable resource [DOI] 10.3389/fmicb.2021.723818 PMC 바로가기 [Article Type] Microbiology
Effects of COVID-19 pandemics on urinary metabolites in kidney stone patients: our kidney stone prevention clinic experienceResearch Article Published on 2021-12-022022-10-31 Journal: Environmental health and preventive medicine [Category] COVID-19, SARS, [키워드] 24-h urine Affect change COVID-19 COVID-19 pandemic decrease diet Dietary changes dietary habit dietary intake Effect evaluated follow-up visits investigated Iran kidney kidney stone medical record metabolite metabolites oxalate Pandemics Patient patients patients’ medical record Potassium prevention Protein Result risk factor shown significantly higher significantly lower sodium Tehran urea uric acid Urine [DOI] 10.1186/s12199-021-01037-w PMC 바로가기 [Article Type] Research Article
Towards risk stratification and prediction of disease severity and mortality in COVID-19: Next generation metabolomics for the measurement of host response to COVID-19 infectionCOVID-19의 위험 계층화 및 질병 중증도 및 사망률 예측: COVID-19 감염에 대한 숙주 반응 측정을 위한 차세대 대사체학Research Article Published on 2021-12-012022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] abnormality Admission alteration association AUC biochemical Carnitine change changes in Characteristics characterized citrulline clinical evaluation Clinical management clinical severity score collected Comorbidities Comorbidity Concentration Confirmed COVID-19 infection COVID-19 COVID-19 infection COVID-19 severity Curve demographics determinant develop disease disease severity enrolled Glutamate healthy volunteers highest Host host response identify immune signature implication individual investigated Kynurenine mass spectrometry measure medical records metabolic factors metabolism metabolite metabolites metabolomics Mild moderate morbidity morbidity and mortality Mortality organic acid ornithine Patient Peripheral blood Peripheral blood sample peripheral blood samples plasma predictor profile Prognosis Prognostic marker Prognostic markers Quantitative receiver risk risk stratification ROC RT-PCR selected severe complication severe complications severity tested Tryptophan urea urea cycle WHO [DOI] 10.1371/journal.pone.0259909 PMC 바로가기 [Article Type] Research Article
Identification of tear-based protein and non-protein biomarkers: Its application in diagnosis of human diseases using biosensorsReview article Published on 2021-12-012022-10-05 Journal: International journal of biological macromolecules [Category] SARS, 바이오마커, [키워드] ACE2angiotensin-converting enzyme 2 acetylcarnitine ADAlzheimer's disease advanced glycation end product AGEadvanced glycation end product Alzheimer's disease angiotensin-converting enzyme 2 antibody binding Biomarker Complication Coronavirus disease-19 COVID-19Coronavirus disease-19 diabetes Diabetic Diabetic retinopathy Diagnosis diagnosis and monitoring disease Diseases DRdiabetic retinopathy early diagnosis enzyme eye GOgraves orbitopathy graves orbitopathy highlight human disease human diseases identification IFN-γInterferon- γ Interferon- γ interleukin-6 lactotransferrin lysophospholipid metabolites MONITOR NCPnovel coronavirus pneumonia non-proliferative diabetic retinopathy novel coronavirus pneumonia NPDRnon-proliferative diabetic retinopathy ocular PACGprimary angle closure glaucoma Parkinson's Disease PDParkinson's disease PDRproliferative diabetic retinopathy PEGpsedoexfoliation glaucoma PEXpsedoexfoliation syndrome POAGprimary open angle glaucoma Potential biomarker primary angle closure glaucoma primary open angle glaucoma progression proliferative diabetic retinopathy Protein psedoexfoliation glaucoma psedoexfoliation syndrome Repository reverse transcription polymerase chain reaction robust RT-PCRreverse transcription polymerase chain reaction selective specific biomarker Tear Thyroid TNF-αtumor necrosis factor α tumor necrosis factor α vascular endothelial growth factor VEGFvascular endothelial growth factor [DOI] 10.1016/j.ijbiomac.2021.10.198 [Article Type] Review article
Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based IsolationReview Published on 2021-11-262022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] adhesion Affect affecting Anti-inflammatory anticancer Biomolecule biosensors CAM can be used Cell Cell adhesion cellular classical Compound concerning Effect Effects Evidence experiment faster fungi Gene Expression greater Health highlighting integrin Isolation knowledge mechanism metabolite metabolites Migration movement natural natural compound plant plants preparation quantification SARS-CoV-2 SARS-CoV-2 treatment signaling pathway Stimulation surface receptor target viability virus [DOI] 10.3390/biomedicines9121781 PMC 바로가기 [Article Type] Review
Probiotics Regulating Inflammation via NLRP3 Inflammasome Modulation: A Potential Therapeutic Approach for COVID-19Review Published on 2021-11-172022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ACE2 adaptive Bacterial cellular damage clinical trial COVID-19 COVID-19 pathogenesis cytokine release cytoplasmic dosage Effect Effectiveness Evidence Ex vivo forms highlighting host’s immune system Human immune response immune systems immunomodulatory implicated in vivo indicate inflammasome activation inflammasomes inflammation markers inflammatory conditions inflammatory process Invasion mammalians management metabolites microbial infection modulate multiprotein complex NLRP3 NLRP3 activation NLRP3 inflammasome pathophysiological mechanism Potential preclinical study presenting probiotic bacteria Probiotics protein 3 Regulating Regulation Replication Research SARS-CoV-2 SARS-COV-2 infection shown strain trials virus with COVID-19 [DOI] 10.3390/microorganisms9112376 PMC 바로가기 [Article Type] Review