The great escape? SARS-CoV-2 variants evading neutralizing responses대단한 탈출? 중화 반응을 회피하는 SARS-CoV-2 변종Article Published on 2021-03-102022-09-11 Journal: Cell Host & Microbe [Category] Fulltext, SARS, 변종, 진단, [키워드] article Efficacy highlight immunotherapies microbe Mutation neutralizing response neutralizing responses Receptor binding domain Reinfection SARS-CoV-2 evolution SARS-CoV-2 variant spike Spike receptor binding domain Surveillance the SARS-CoV-2 Vaccine vaccine efficacy variant [DOI] 10.1016/j.chom.2021.02.010 PMC 바로가기 [Article Type] Article
Integrated photothermal decontamination device for N95 respiratorsArticle Published on 2021-01-192022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] acute respiratory syndrome Bacteria biomedical engineering coronavirus COVID-19 COVID-19 pandemic death Disease prevention effective Efficacy evaluated global pandemic Health Mask Masks microbe N95 respirator N95 respirators Personal protective equipment PPE reduce Region responsible SARS-CoV-2 tested Treatment Vaccine virus [DOI] 10.1038/s41598-020-80908-8 PMC 바로가기 [Article Type] Article
Exploring the Applicability of Robot-Assisted UV Disinfection in RadiologyRobotics and AI Published on 2021-01-062022-10-31 Journal: Frontiers in Robotics and AI [Category] COVID-19, [키워드] approach burst Cell complex Concentration conducted coronavirus COVID-19 demonstrated Disinfection disinfection methods Effectiveness equipment Evidence experiment faster feasibility finding germicidal HCAI hospital inactivated inactivation increasingly infection control Intensive investigated irradiation likelihood limitation microbe microbial overcome patients platform radiology radiology robot reduced Research resource robotics SARS-CoV-2 significantly Spread Structure UV robot UVGI X-ray room [DOI] 10.3389/frobt.2020.590306 PMC 바로가기 [Article Type] Robotics and AI
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2Report Published on 2020-12-182022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affinity Anti-spike antibody Bacteria cells complex Concentration coronavirus COVID-19 pandemic group half-maximal inhibitory concentration identify immunization inactive indicated inhibit intravenously mammalian cell mechanisms microbe multivalent nanobodies nanobody neutralization neutralization potency neutralize Neutralizing nonoverlapping epitope potent Prevent produced proteomics RBD Receptor binding domain SARS-CoV-2 Science screened selected Spike protein stability synthetic nanobody the RBD the spike protein therapeutic viral infection yeast [DOI] 10.1126/science.abe4747 PMC 바로가기 [Article Type] Report
Bioactivity Potential of Marine Natural Products from Scleractinia-Associated Microbes and In Silico Anti-SARS-COV-2 EvaluationScleractinia 관련 미생물 및 In Silico Anti-SARS-COV-2 평가에서 해양 천연 제품의 생물학적 활성 가능성Review Published on 2020-12-162022-09-10 Journal: Marine Drugs [Category] SARS, 치료제, [키워드] (RdRp activity ADME ADME analysis Analysis Bacteria biological activity Cancer Compound compounds Coverage determine Diseases drug filtered fungi hierarchy Inflammation investigated leads malaria marine bacteria marine fungi marine natural products methyltransferase microbe molecular docking molecular docking studies natural organism Organisms Physicochemical properties Potential producing product RdRP Research responsible RNA dependent RNA polymerase RNA polymerase RNA-dependent RNA polymerase SAR SARS-CoV-2 SARS-CoV-2 RNA Scleractinia Secondary Metabolite secondary metabolites selected structure activity relationship target these compound Viral diseases zooxanthellae [DOI] 10.3390/md18120645 PMC 바로가기 [Article Type] Review
Plant Molecular Farming as a Strategy Against COVID-19 – The Italian PerspectivePlant Science Published on 2020-12-142022-10-31 Journal: Frontiers in Plant Science [Category] COVID-19, [키워드] acute respiratory syndrome affected Against antibodies antibody calculate caused complement coronavirus COVID-19 diagnostic diagnostic reagent diagnostics Epidemiology Farming health system Immunotherapy Italian Italy mammalian cells measure microbe molecular molecular farming plant PROTECT protein antigen Proteins reagent recombinant proteins reduce mortality required SARS-CoV-2 Strategy subsequent Surveillance therapeutic Therapeutics transient expression Vaccine vaccine candidates Vaccines virus virus detection Virus-like particle widespread [DOI] 10.3389/fpls.2020.609910 PMC 바로가기 [Article Type] Plant Science
Predicting human microbe-drug associations via graph convolutional network with conditional random field조건부 랜덤 필드가 있는 그래프 컨볼루션 네트워크를 통한 인간 미생물-약물 연관성 예측Article Published on 2020-12-082022-09-11 Journal: Bioinformatics [Category] MERS, SARS, 신약개발, 치료제, [키워드] aggregate antimicrobial drug approach association associations bioinformatics boost can not case studies case study ciprofloxacin complex interaction computational approach Conditional Random Field CRF Critical dataset drug Drug development Drug discovery drugs Effectiveness Experimental result experimental results experiments feature field heterogeneous heterogeneous network hidden Human identifying information Interaction mechanism microbe microbes moxifloxacin performed Precision random random walk restart risk SARS-CoV-2 Seven similarity [DOI] 10.1093/bioinformatics/btaa598 PMC 바로가기 [Article Type] Article
Defensive Properties of Mucin Glycoproteins during Respiratory Infections—Relevance for SARS-CoV-2Minireview Published on 2020-11-122022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] activate acute respiratory syndrome adhesin age airway Bacterial boost clearance component Contact coronavirus Defense dependent on downregulation efficient clearance example expressed expression facilitate Factor female glycan glycans glycoprotein glycosylation Inflammatory inflammatory state Interaction Invasion ligands microbe microbial microbial infections Motile cilia MUC1 MUC16 MUC4 MUC5AC MUC5B mucin mucin-microbe interactions mucins mucosal mucosal barrier Mucus Novel coronavirus O -glycosylated O-linked glycans pathogen Pathways Prevent Proinflammatory cytokine property receptors regulated respiratory respiratory infections Respiratory pathogens respiratory tract SARS-CoV-2 sex hormone estradiol Signal transduction the healthy therapy transmembrane understanding upregulated viral infection virulence [DOI] 10.1128/mBio.02374-20 PMC 바로가기 [Article Type] Minireview
Perspective: Reducing SARS-CoV2 Infectivity and Its Associated Immunopathology관점: SARS-CoV2 감염성 감소 및 관련 면역병리학Immunology Published on 2020-10-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료제, [키워드] antibody approach approaches consequence COVID-19 Hyperinflammatory immune immunoregulation Infection Infectivity Inflammation Inflammatory response initiated mediators microbe microbes mitigate nanobodies neutralize organelle outcome Patient reaction reduce referred to SARS-CoV2 sdAb selected Smaller subcellular therapy utility virus viruses [DOI] 10.3389/fimmu.2020.581076 PMC 바로가기 [Article Type] Immunology
IDseq—An open source cloud-based pipeline and analysis service for metagenomic pathogen detection and monitoringTechnical Note Published on 2020-10-152022-10-31 Journal: GigaScience [Category] COVID-19, MERS, SARS, [키워드] Analysis bioinformatics categories Clinicians cloud-based contig COVID-2019 Critical Data analysis data interpretation dataset determine facilitate filtration finding Host Hypothesis Intensive knowledge Local metagenomic metagenomics microbe microbial nasopharyngeal swab sample Next-generation sequencing pathogen detection pathogen-specific Pathogens portal processed reagents reduce reported Research resources SARS-CoV-2 Support viral sequence virus virus detection Wuhan, China [DOI] 10.1093/gigascience/giaa111 PMC 바로가기 [Article Type] Technical Note