Diagnostic Yield of Cardiac Biomarker Testing in Predicting Cardiac Disease and Multisystem Inflammatory Syndrome in Children in the Pandemic EraArticle Published on 2022-10-012022-11-15 Journal: Pediatric emergency care [Category] 바이오마커, [키워드] age Algorithm analyzed Biomarker cardiac cardiac disease children COVID-19 Critical demographics demonstrated diagnose diagnosed Diagnosis diagnostics elevated Elevation inclusion criteria Inflammatory initial MIS-C Multivariable regression analysis N-terminal Odds ratio outcome Patient patients pediatric peptide Primary outcome relationship Retrospective study Sensitivity and specificity single-center syndrome Testing women yield [DOI] 10.1097/PEC.0000000000002804 PMC 바로가기
A machine-learning algorithm for diagnosis of multisystem inflammatory syndrome in children and Kawasaki disease in the USA: a retrospective model development and validation studyArticle Published on 2022-10-012022-11-16 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy age Algorithm Boston Care center characteristic Child childhood children clinician collected Connecticut COVID-19 pandemic develop development diagnosed Diagnosis Diego disease distribution Early detection enrolled Eunice Kennedy Shriver External feature febrile febrile illness first stage FIVE foundation group heart hospital hospitals Human illness illnesses Inflammatory initial IQR Kawasaki disease laboratory measurements library Los Angele machine-learning median Medicine MIS-C Patient Prevent retrospective SARS-COV-2 infection severe complications similarity stratified syndrome systemic inflammation Treatment USA validation study Washington [DOI] 10.1016/S2589-7500(22)00149-2 PMC 바로가기
Trends in Treatments for Multisystem Inflammatory Syndrome in Children (MIS-C), United States, February 2020 – July 2021Article Published on 2022-09-302022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] acute respiratory syndrome administration Admission Analysis analyzed anticoagulation antiplatelet Black patient Case report CDC center children Clinical findings Clinical management Combination Control coronavirus declined Frequency ICU increasingly Inflammatory intensive care Intravenous immunoglobulin Local medication MIS-C multisystem inflammatory syndrome in children National noninvasive respiratory other treatment Patient patients Postinfectious Prevalence prevention proportion receive reported SARS-CoV-2 severity standard treatment steroid Steroids Support Surveillance syndrome therapy Treatment trend United States Vasoactive Ventilation [DOI] 10.1093/cid/ciac072 PMC 바로가기
Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants in Children With Coronavirus Disease 2019, Multisystem Inflammatory Syndrome in Children, and After Two Doses of BNT162b2 VaccinationArticle Published on 2022-09-282022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome ADCC age antibody B.1.1.529 BNT162b2 breadth children coronavirus coronavirus 2 coronavirus disease COVID COVID-19 COVID-19 vaccination cytotoxicity dose elicited enrolled functional greater Inflammatory MIS-C Neutralizing neutralizing antibody of BNT162b2 omicron pediatric protocol pseudovirus reduced respiratory response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serologic significantly syndrome vaccination variants [DOI] 10.1093/infdis/jiac215 PMC 바로가기
A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related studyArticle Published on 2022-09-262022-11-15 Journal: Frontiers in Endocrinology [Category] 진단, [키워드] Abnormalities Analysis available data BMI body mass index childhood Childhood obesity children collected Comorbidity Course COVID-19 COVID-19 infection COVID-19 severity criteria discharge disease entity duration of symptom form Frequency higher risk Hospitalization Inflammatory intensive care Intravenous immunoglobulin MIS-C National no difference obese obesity Odds ratio Oxygen therapy participant pathophysiology Patient patients patients with obesity PIMS Poland populations pro-inflammatory recruited risk factor syndrome Treatment worsening [DOI] 10.3389/fendo.2022.934373 PMC 바로가기
Clinical characteristics and outcomes of the multisystem inflammatory syndrome in children (MIS-C) following COVID-19 infection in Iran: A multicenter studyArticle Published on 2022-09-222022-11-15 Journal: PLoS ONE [Category] SARS, 진단, [키워드] Admission Analysis CDC Characteristics Chi-square children clinical Clinical characteristics Clinical sign collected Comorbidities Comorbidity Control COVID-19 COVID-19 infection criteria demographic characteristics died discharged drug epidemiological FIVE Gastrointestinal geographical region hematologic Inflammatory injection Iran Laboratory Lung CT median median age MIS-C MOST Most patient multicenter multicenter observational study obesity outcome Patient patients Positive test prevention RT-PCR serology steroid Steroids Symptoms syndrome t-test tested the patient tongue treated Treatment two group two groups [DOI] 10.1371/journal.pone.0274104 PMC 바로가기
B-Cell Responses in Hospitalized Severe Acute Respiratory Syndrome Coronavirus 2-Infected Children With and Without Multisystem Inflammatory SyndromeArticle Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome antibodies antibody Antibody avidity Antibody Response antibody-secreting cell antibody-secreting cells Antiviral antiviral antibody B cell B cells B-cell response children circulation complicate coronavirus coronavirus disease COVID-19 COVID-19 patient demonstrated flow cytometry Follow-up group Hospitalized IgG immune response Immunoglobulin Infection Inflammatory MIS-C phenotype plasma Postinfectious proportion respiratory response SARS-CoV-2 sustained syndrome those with MIS-C with COVID-19 [DOI] 10.1093/infdis/jiac119 PMC 바로가기
SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants eraArticle Published on 2022-09-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] Affect Asymptomatic available data B.1.1.529 B.1.617.2 caused children clinical manifestation clinical manifestations Complication conditions coronavirus disease country COVID-19 Delta delta variant Direct drastic exacerbating Google Scholar Health highest highlight Hospitalization immune response Immunodepressive incidence Infant Infants infected children Infection Manifestations Mild MIS MIS-C occur omicron Omicron variant pandemic pediatric Prevalence prevalence of COVID-19 proportion reported Risk factors SARS-COV-2 infection Science suggested symptomatic SARS-CoV-2 infection Symptoms the United State Transmission dynamics vaccination variant variants virulent [DOI] 10.1186/s12985-022-01873-4 PMC 바로가기
IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohortArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] African Anti-inflammatory Antiviral change children clinically Cohort condition conditions Control controls COVID-19 cytokine differential expression differentially expressed gene down-regulated gene expression febrile febrile illness Follow-up Gene Expression healthy healthy children healthy controls highlight IL-27 IL27 immune gene immune-related gene Inflammatory inflammatory condition inflammatory conditions inflammatory reaction innate immune pathway innate immune system investigated Kawasaki disease lack longitudinal MIS-C Multisystem inflammatory syndrome Other pathway Patient pyroptosis quantitative PCR resolved SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity South South Africa specimen syndrome systemic lupus erythematosus timepoints Treatment two group unique up-regulated was determined [DOI] 10.3389/fimmu.2022.992022 PMC 바로가기
Circulating Endothelial Cells: A New Possible Marker of Endothelial Damage in Kawasaki Disease, Multisystem Inflammatory Syndrome in Children and Acute SARS-CoV-2 InfectionArticle Published on 2022-09-032022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 바이오마커, 치료기술, [키워드] acute COVID-19 Biomarker Cell CellSearch characterized children circulating circulating endothelial cells conducted coronary artery lesions correlation COVID-19 damage decrease disease Diseases endothelial Endothelial cell Endothelial dysfunction endothelial injury enrolled incidence Inflammatory Kawasaki disease lesion mechanism Mild MIS-C multicenter multisystem inflammatory syndrome in children New Patient patients pediatric Prospective Study SARS-CoV-2 syndrome systemic inflammation Vascular injury Whole blood [DOI] 10.3390/ijms231710106 PMC 바로가기