Dynamics of SARS-CoV-2 mutations reveals regional-specificity and similar trends of N501 and high-frequency mutation N501Y in different levels of control measuresSARS-CoV-2 돌연변이의 역학은 다양한 수준의 통제 조치에서 N501 및 고주파 돌연변이 N501Y의 지역 특이성과 유사한 경향을 나타냅니다Article Published on 2021-09-072022-09-10 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation calculate caused characterized classification combinations contagious contagious disease coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 case COVID-19 cases death disease Dynamics effective evaluate the effect Evolution Frequency Genome Intervention measure molecular evolution Mutation mutations N501Y N501Y mutation normalization NPIs pandemic Prevalence Region regions relative frequency Reproduction number respiratory reveal SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations sequenced severe acute respiratory syndrome Coronavirus Spread temporal dynamics Viral viral adaptation Viral genetics virus Virus evolution [DOI] 10.1038/s41598-021-97267-7 PMC 바로가기 [Article Type] Article
No species-level losses of s2m suggests critical role in replication of SARS-related coronavirusesArticle Published on 2021-08-092022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome conserved coronavirus Critical experiment Genetic less Lineage molecular evolution related viruses Replication SARS-CoV-2 SARS-related coronavirus SARS-related coronaviruses transfer variant Viral genetics virus replication viruses [DOI] 10.1038/s41598-021-95496-4 PMC 바로가기 [Article Type] Article
Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021Article Published on 2021-08-052022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] approaches assigned B.1.1.28 B.1.1.33 B.1.1.7 B.1.351 B.1.617.2 Brazil clade Consequences COVID-19 COVID-19 pandemic described diffusion dispersal E484K mutation epidemiological genomic High-throughput nucleotide sequencing identify Immunity Infectious diseases introduced Lineage molecular Molecular epidemiology molecular evolution Mortality Mutation P.1 P.2 Phylogenetic Phylogeny Porto Prevalence prevalent lineage Region replaced Rio Grande SARS-CoV-2 lineage sequence sequenced severe acute respiratory syndrome coronavirus 2 South Africa Substitution Surveillance the SARS-CoV-2 Transmissibility United Kingdom viral sample [DOI] 10.3390/pathogens10080988 PMC 바로가기 [Article Type] Article
Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects세포변성 및 융합생성 효과가 강화된 고주파수 인트라호스트 SARS-CoV-2 스파이크 변이체 식별Research Article Published on 2021-06-292022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acids analyzed coronavirus COVID-19 cytopathic effects data sets disease Diversity Effect enhanced Evolution exhibit exonuclease Factors Frequency gene encoding genetic diversity Genetic variant genetic variants High-throughput sequencing Host hosts identification infected cell infected individual infected individuals involved M protein Missense mutation molecular molecular evolution MOST Mutation Neutral produced Proofreading Protein Quasispecies Replication respiratory resulting RNA-dependent RNA polymerase S protein SARS-CoV-2 SARS-CoV-2 variants sequence sequencing data severe acute respiratory syndrome Coronavirus spike Spike protein Syncytia syncytium formation the S protein transmitted Variation variations Viral viral spike virus [DOI] 10.1128/mBio.00788-21 PMC 바로가기 [Article Type] Research Article
Adaptation of the endemic coronaviruses HCoV-OC43 and HCoV-229E to the human hostResearch Article Published on 2021-06-242022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] accessory proteins accompanied accumulated adaptation antigenic antigenic drift applied approach binding affinity both virus both viruses cellular receptor class coronavirus Coronaviruses driven by Endemic endemic coronavirus event Evolution evolutionary dynamics generate HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoV-OC43 spike Hemagglutinin-esterase higher affinity highly pathogenic human cell human host human populations Hypothesis I, II Immunity indicated Infection Like Limited genetic diversity Membrane proteins molecular dating molecular evolution much higher Positive selection Protein RBD RBDs Receptor binding Result SARS-CoV-2 evolution selected selective Spike protein strain suggested targets the RBD the receptor-binding domain the spike protein time interval trajectory undergo virus zoonotic zoonotic origins [DOI] 10.1093/ve/veab061 PMC 바로가기 [Article Type] Research Article
The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations심각한 Covid-19의 주요 유전자 위험 인자는 남아시아 인구의 연관성을 나타내지 않습니다.Article Published on 2021-06-112022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 appear association Case fatality rate correlation COVID-19 dataset European Evidence Evolutionary genetics Fatality rate genetic loci genetic risk factor genomic greater Haplotype India Infection infection rate loci modulate molecular evolution Neanderthal polymorphism Population Population genetics populations recent responsible risk Risk factors severe COVID-19 severity South Asian susceptibility [DOI] 10.1038/s41598-021-91711-4 PMC 바로가기 [Article Type] Article
Evolutionary history of hepatitis B virus genotype HArticle Published on 2021-06-012023-06-12 Journal: Journal of medical virology [Category] B형 간염, [키워드] Bayesian coalescent analysis Hepatitis B virus molecular evolution [DOI] 10.1002/jmv.26463
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil브라질 마나우스의 P.1 SARS-CoV-2 계통의 유전체학 및 역학Research Article Published on 2021-05-212022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] accelerate accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed angiotensin angiotensin-converting enzyme 2 binding Brazil Characteristics circulation CLOCK coronavirus country COVID-19 cases Critical death disease spread E484K enhanced Epidemiology Evolution faster Genome sequencing genomic Genomics Health human ACE2 Immune escape immune evasion indicated Infection Lineage lineages Local molecular molecular evolution mortality data mutations N501Y occurred P.1 pandemic pattern primary care provide reached receptor respiratory SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant Science Sequencing severe acute respiratory syndrome Coronavirus Spike protein Spread spread of COVID-19 suffered Surveillance the spike protein Transmissibility Transmission Trio variant variants variants of concern virus viruses [DOI] 10.1126/science.abh2644 PMC 바로가기 [Article Type] Research Article
Genomic epidemiology of SARS-CoV-2 in Esteio, Rio Grande do Sul, Brazil브라질 리오그란데두술 Esteio의 SARS-CoV-2 게놈 역학Research Published on 2021-05-202022-09-10 Journal: BMC Genomics [Category] SARS, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected Amino acid amino acids Analysis association B.1.1.33 B.1.351 Brazil Case fatality rate CFR characteristic Clusters comprehensive view coronavirus coronavirus disease coronavirus disease-2019 country COVID-19 D614G distribution E484K epidemiological Epidemiology Evolution Fatality rate Genome genomic information highlighting immune evasion Infectious diseases Inference Lineage lineages molecular Molecular epidemiology molecular evolution Mutation Nucleocapsid phosphoprotein P.1 Patient phylogenetics prevalent lineage provided RBD regions respiratory Result Rio Grande SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein Spike receptor binding domain Spread subject supplementary material Surveillance Viral viral evolution viral spread [DOI] 10.1186/s12864-021-07708-w PMC 바로가기 [Article Type] Research
SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes44개의 Sarbecovirus 게놈을 비교하여 SARS-CoV-2 유전자 함량 및 COVID-19 돌연변이 영향Comparative Study Published on 2021-05-112022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료법, [키워드] Analysis annotation B-cell epitope Cluster Comparative genomics conservation conserved contribute COVID-19 COVID-19 pandemic D614G Dissection E484K epitope evidence of Evolution except for experimental evidence functional mutation functional mutations Genome individual lack molecular evolution Mutation mutations N501Y Nsp3 nucleocapsid nucleotide ORF ORF3c ORF8 ORFs overlapping predicted protein-coding gene provide reported residue residues SARS-CoV-2 SARS-CoV-2 biology Sequence annotation spike-protein strain Substitution the SARS-CoV-2 Transmission valuable resource [DOI] 10.1038/s41467-021-22905-7 PMC 바로가기 [Article Type] Comparative Study