Molecular medicine – Page 7 – Communicable Diseases Research

Multiplex quantification of C-terminal alpha-1-antitrypsin peptides provides a novel approach for characterizing systemic inflammation

Article

Published on 2022-03-092022-10-04
Journal: Scientific Reports [Category] 바이오마커,

Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture

Article

Published on 2022-02-222023-06-16
Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS,

[키워드] Molecular medicine Pharmacology
[DOI] 10.1038/s42003-022-03101-9 PMC 바로가기 [Article Type] Article

Multiplex real-time RT-PCR method for the diagnosis of SARS-CoV-2 by targeting viral N , RdRP and human RP genes

Article

Published on 2022-02-182022-10-04
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

Immune responses following the first dose of the Sputnik V (Gam-COVID-Vac)

Sputnik V의 첫 번째 용량 (Gam-Covid-Vac) 이후의 면역 반응

Comparative Study

Published on 2022-02-022022-09-01
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단,

[키워드] ACE2 receptor Adaptive immunity administration antibodies antibody Antimicrobial responses AZD1222 B.1.1.7 B.1.351 B.1.617.2 CD107a Cell ELISPOT ELISpot responses Ex vivo expressing first dose Frequency Gam-COVID-Vac IFNγ immunogenic immunogenicity immunology in some Infection Infectious diseases investigated Lymphocytes memory B memory B cell Microbiology Molecular medicine naïve individuals natural infection Receptor binding domain response responses second dose seroconversion rate seroconverted significantly higher significantly lower single dose T cell T cells titre Vaccine Vaccines
[DOI] 10.1038/s41598-022-05788-6 PMC 바로가기 [Article Type] Comparative Study

Structural biology of SARS-CoV-2: open the door for novel therapies

SARS-COV-2의 구조 생물학 : 새로운 요법을위한 문을여십시오.

Review

Published on 2022-01-272022-08-31
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] accessory protein Adsorption assembly causative agent caused cellular complexes COVID COVID-19 Critical door drug-target ENCODE Factor Host imperative in viral Infection involved life cycle mechanism member Molecular medicine nucleic acid open Orthocoronavirinae pandemic disease pandemic disease COVID-19 partner physiological activities potential therapy Prevent Protein reagent Replication respiratory RNA genome SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 structural biology Structure structures target proteins the disease Therapies therapy Transcription treat treating COVID-19 Treatment Viral viral infection viral life cycle viral pathogenesis viral variant Viral variants
[DOI] 10.1038/s41392-022-00884-5 PMC 바로가기 [Article Type] Review

Six-year trend analysis of malaria prevalence at University of Gondar Specialized Referral Hospital, Northwest Ethiopia, from 2014 to 2019

2014년부터 2019년까지 에티오피아 북서부 곤다르 대학교 전문 치료 병원에서 말라리아 유병률에 대한 6년 추세 분석

Article

Published on 2022-01-262024-08-08
Journal: Burma Med J [Category] 말라리아,

[키워드] Biomarkers Diseases immunology Medical research Microbiology Molecular biology Molecular medicine
[DOI] 10.1038/s41598-022-05530-2 PMC 바로가기 [Article Type] Article

Overexpression of the SARS-CoV-2 receptor angiotensin converting enzyme 2 in cardiomyocytes of failing hearts

Article

Published on 2022-01-192022-10-04
Journal: Scientific Reports [Category] 바이오마커,

[키워드] ACE2 ACE2 expression ACE2 receptor Biochemistry Biomarkers Biotechnology Cardiology cardiovascular comorbidity Cell Biology dependent on disease Diseases Donor Endothelial cell endothelial cells enzyme expressed expression fibroblast fibroblasts healthy donor heart heart failure hearts immunohistochemistry immunology in both groups infect cells Medical research Molecular biology Molecular medicine myocarditis organ outcome Patient Physiology proteomics Quantitative receptor risk RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus subpopulation the SARS-CoV-2 tissue ventricular was measured was used
[DOI] 10.1038/s41598-022-04956-y PMC 바로가기 [Article Type] Article

A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections

Clinical Trial

Published on 2022-01-182022-10-04
Journal: Scientific Reports [Category] 바이오마커, 임상, 진단, 치료제,

[키워드] 30-Day mortality acute viral infection assist Care Classifier clinical study Cohort COVID-19 determine develop enrolled facilitate Gene Expression healthcare Host Host immune response host response illnesses implementation in viral independent Infection Infectious diseases Influenza isothermal Logistic Logistic regression machine learning management medical need Molecular medicine outcome Patient predict Prognostic markers reducing retrospective retrospective cohort risk RNA RNAs selected severe respiratory failure severity severity of COVID-19 Statistical methods training data transcriptomic Viral illness viral infection Whole blood
[DOI] 10.1038/s41598-021-04509-9 PMC 바로가기 [Article Type] Clinical Trial

Systematic identification of NF90 target RNAs by iCLIP analysis

Article

Published on 2022-01-102022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

Molecular surveillance of pneumococcal carriage following completion of immunization with the 13-valent pneumococcal conjugate vaccine administered in a 3 + 1 schedule

13가 폐렴구균 결합 백신을 3+1 일정으로 접종한 후 폐렴구균 보유에 대한 분자 감시

Article

Published on 2021-12-302024-07-30
Journal: Burma Med J [Category] 폐렴구균 감염증,

[키워드] Epidemiology Molecular medicine Paediatric research
[DOI] 10.1038/s41598-021-03720-y PMC 바로가기 [Article Type] Article