Platelet and immune signature associated with a rapid response to the BNT162b2 mRNA COVID-19 vaccineBNT162b2 mRNA COVID-19 백신에 대한 신속한 반응과 관련된 혈소판 및 면역 신호Article Published on 2022-04-012022-09-12 Journal: Journal of thrombosis and haemostasis : JTH [Category] COVID19(2023년), SARS, 진단, [키워드] aggregates B cells Biomarker BNT162b2 BNT162b2 mRNA CD31 circulating platelet COVID-19 COVID-19 vaccine Critical cytokine response dose effective Efficacy elevated enrolled eosinophils expressed feature females first dose healthy volunteer humoral identify immune response immune signature immune system Immunity inhibitory leukocyte median motif mounted mRNA-based COVID-19 vaccine mRNA-based vaccine neutralizing antibody non-classical monocyte of BNT162b2 participant Platelet platelet activation Platelet count rapid immune response rapid response reactive receptor responders second dose stability stimulate the vaccine Vaccine Vaccines Vascular [DOI] 10.1111/jth.15648 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an α v β 3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing AntibodiesSARS-CoV-2는 백신 유도 중화 항체가 있는 경우에도 α v β 3 인테그린 매개 세포내이입을 통해 인간 ACE2 음성 내피 세포를 감염시킵니다Article Published on 2022-03-292022-09-11 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] absence ACE2 acute respiratory syndrome Angiogenesis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-spike antibodies antibody BNT162b2 BNT162b2 vaccine Cell clathrin conserved endocytosis Endothelial cell endothelial cell dysfunction endothelial cells enzyme Evidence expression functional gateway highlight Human human lung impair Infection inhibit SARS-CoV-2 integrin integrin-mediated Integrins Interaction Intervention Lineage maintain monoclonal antibody motif neutralize phenotype Presence Prevent productive viral replication promote Protein RBD Receptor binding domain respiratory responsible RGD motif SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants sequence Spike protein the SARS-CoV-2 the Spike the vaccine vaccination Viral viral envelope virus viruses αvβ3 integrin αvβ3 integrin. [DOI] 10.3390/v14040705 PMC 바로가기 [Article Type] Article
The “LLQY” Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus ParticlesSARS-CoV-2 스파이크 단백질의 "LLQY" 모티프는 S가 바이러스 입자에 통합되는 데 영향을 줍니다.Article Published on 2022-03-232022-09-11 Journal: Journal of Virology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Alter Amino acid amino acid residue amino acids antiviral drug antiviral drugs assembly biological significance Biosynthesis caused Cell culture cleavage cleavage site cleavage sites cleaved conformational conservation conserved Contact contribute coronavirus COVID-19 epidemic Critical demonstrated Effectiveness expressed glycoprotein hydrogen Hydrogen bond hydrogen bonds incorporation Infection intrachain junction key amino acid key amino acids less Lineage LLQY domain membrane fusion motif mutated Mutation Neutralizing antibodies Particle Prevent processing producer cell protease Protein protein synthesis protein synthesis and cleavage Pseudotyped virus pseudovirus pseudoviruses reduce residue S protein S1/S2 SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein stability subcellular localization synthesis the S protein the SARS-CoV-2 Transmission tyrosine Vaccines viral entry viral infection virus virus assembly Virus-like particle virus-like particles [DOI] 10.1128/jvi.01897-21 PMC 바로가기 [Article Type] Article
[SARS-CoV-2 with transcription regulatory sequence motif mutation poses a greater threat][전사 조절 서열 모티브 돌연변이를 가진 SARS-CoV-2는 더 큰 위협이 된다]Article Published on 2022-03-202022-09-11 Journal: Nan fang yi ke da xue xue bao = Journal of Souther [Category] SARS, 변종, 치료기술, [키워드] Analysis Asia Asymptomatic B.1.617.2 change Chinese cleavage consensus sequence CoV CoV genome Cross-species transmission defined Delta delta variant detection rate English functional genomic data greater humans increase in Incubation period mild infections molecular motif Mutation mutations NSP15 cleavage site nucleotide occur ORF1a outbreak Outbreaks Pandemics Prevention and control regulatory sequences residue SARS-CoV-2 SARS-CoV-2 transmission shown significantly Singapore Spread super-attenuated variant. Transcription transcription regulatory sequence Transcription Regulatory Sequences Transmission TRS TRS-B TRS-L TRSs upstream UTR variant variants variants of SARS-CoV-2 virus viruses was performed [DOI] 10.12122/j.issn.1673-4254.2022.03.12 PMC 바로가기 [Article Type] Article
Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases사용 가능한 세포 프로테아제에 대한 신속한 SARS-CoV-2 적응Article Published on 2022-03-092022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptation Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 binding cathepsin Cathepsins cleavage clinical isolates conditions Consensus coronavirus coronavirus spike priming deep sequencing delta variant dominant Efficiency Evolution furin furin cleavage motif furin cleavage site Genome genomes genomic Genotype growth heparan sulfate highlight human cell human cells identify independent inhibit isolate isolates lack mechanism minor motif mutated Omicron variant processed protease Proteases Rapid recent S1/S2 site SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection pressure selective sequence spike mutation spike mutation. Spike protein spike protein of SARS-CoV-2 spike variant stability subpopulation sulfate Surveillance the spike protein These cells TMPRSS2 variant variants Vero Vero E6 Vero E6 cell VERO E6 cells virus virus growth virus pathogenesis wild type [DOI] 10.1128/jvi.02186-21 PMC 바로가기 [Article Type] Article
The Slowing Rate of CpG Depletion in SARS-CoV-2 Genomes Is Consistent with Adaptations to the Human HostSARS-CoV-2 게놈에서 CpG 고갈의 둔화 속도는 인간 숙주에 대한 적응과 일치합니다Discoveries Published on 2022-03-032022-09-10 Journal: Molecular Biology and Evolution [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptation alpha- analyzed Antiviral antiviral protein Beta coding regions codon positions Coronavirus-2 CpG CpG depletion Depletion dinucleotide driven by equilibrium Evidence Evolution full-length SARS-CoV-2 genome Genome genomes help highest highlight Host Human human host immune immune responses Infection innate immune responses Loss majority motif motifs occur pandemic Rate reduced representing respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes selection pressure sequence sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Temporal temporal variation TLR7 variants of concern Variation variations virus Virus evolution virus genome virus genomes virus replication ZAP ZAP-binding motif Zinc [DOI] 10.1093/molbev/msac029 PMC 바로가기 [Article Type] Discoveries
Genetic prediction of ICU hospitalization and mortality in COVID-19 patients using artificial neural networks인공신경망을 이용한 코로나19 환자 중환자실 입원 및 사망률의 유전적 예측Article Published on 2022-03-012022-09-11 Journal: Journal of Cellular and Molecular Medicine [Category] 변종, [키워드] absence ADAMTS13 age age and gender ANN artificial intelligence Artificial neural network C3a CD46 CD55 CFB CFD CFH CFHR1 CFI Clinical outcome clinical outcomes complement complement inhibition coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical death death in COVID-19 develop disintegrin dysregulation examined Gender Genes Genetic genetic susceptibility genetic susceptibility. Genetic variant genetic variants Hospitalization Hospitalized ICU identified variant identify metalloproteinase morbidity morbidity and mortality Mortality motif Next-generation sequencing outcome Patient patients phenotype presence or absence recruited SARS-CoV2 severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly increased THBD thrombomodulin Thrombospondin unmet need variant variants [DOI] 10.1111/jcmm.17098 PMC 바로가기 [Article Type] Article
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signalingSARS-CoV-2의 스파이크 단백질은 인테그린 α5β1 및 NF-κB 신호 전달을 통해 내피 염증을 유도합니다Article Published on 2022-03-012022-09-11 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 activate Activation addition adhesion Adhesion Molecule administration bind Blood Capillaries CD45 Coagulation coagulation factor Coagulation factors COVID-19 Critical Cytokines dependent on domain dysfunction dysregulated edema Effects endothelial Endothelial cell endothelial cells Endothelial dysfunction expression FVIII hallmark hallmarks homeostasis ICAM1 IL-1β IL-6 in vivo increased expression Incubation induce Inflammation inflammatory phenotype inhibitor inhibitors integrin intravenous Intravenous administration intravitreal injection kidney leukocyte leukocytes liver lung maintain mechanism motif NF-κB NF-κB signaling nuclear translocation occur Peripheral blood peripheral blood leukocyte peripheral blood leukocytes permeability prevented Proinflammatory cytokine proinflammatory cytokines Receptor-binding domain responsible SARS-CoV-2 severe disease Signaling Spike protein spike protein of SARS-CoV-2 subsequent target gene the receptor-binding domain the spike protein tissue tissues TNFα umbilical umbilical vein vascular effect vascular endothelial cells vascular inflammation vascular leakage VCAM1 [DOI] 10.1016/j.jbc.2022.101695 PMC 바로가기 [Article Type] Article
Capturing a Crucial ‘Disorder-to-Order Transition’ at the Heart of the Coronavirus Molecular Pathology—Triggered by Highly Persistent, Interchangeable Salt-BridgesArticle Published on 2022-02-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anionic appear arginine baseline being binding catalytic cationic characteristic cleavage site coronavirus COVID-19 disorder disorder-to-order transition enthalpy entropy compensation entropy arrest events Evolution feature FLCS flexible furin cleavage Genome heart homologous Host increase in Interaction interactions Lineage Molecular pathology motif multiplicity offer persistent polybasic Protein proteolytic proteolytic cleavage residue respiratory viral diseases respiratory viruses S1/S2 junction salt-bridge salt-bridge dynamics SARS-CoV SARS-CoV-2 spike Spike–Furin interaction the SARS-CoV-2 Transmissibility [DOI] 10.3390/vaccines10020301 PMC 바로가기 [Article Type] Article
Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein합성 비리온은 SARS-CoV-2 스파이크 당단백질의 지방산 결합 적응 면역원성을 나타냅니다.Article Published on 2022-02-142022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adaptive binding binding pocket Bioinspired materials Cell conserved convalescent COVID-19 COVID-19 progression Dexamethasone Donor fatty Fatty acid fatty acids FDA-approved drug FFAs free fatty acid function global public health glycoprotein heterogenous Host immune response immunogenicity Immunoglobulin immunoglobulins Inflammation Inflammatory integrin Live virus mechanism mimicking modulate molecular motif Mutant SARS-CoV-2 neutralization activity Neutralizing open Pathogenesis preparation pro-inflammatory proinflammatory protocol RBD Receptor binding Receptor binding domain Regulation Regulatory responsible reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein synthetic the SARS-CoV-2 Variability Viral virion vitamin K wild-type [DOI] 10.1038/s41467-022-28446-x PMC 바로가기 [Article Type] Article