Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria비교 전사체 분석은 말라리아 마우스 모델에서 번역적으로 관련된 과정을 밝혀냅니다.Article Published on 2022-01-102024-08-08 Journal: eLife [Category] 말라리아, [키워드] malaria mouse Mouse models transcriptomics [DOI] 10.7554/eLife.70763 PMC 바로가기
SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction?원발성 갑상선 육종에서 SARS-CoV-2 검출: 우연인가 상호작용인가?Case Reports Published on 2022-01-052022-09-10 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] analyzed Chain Reaction COVID-19 epidemic cytology cytopathic cytoplasmic demonstrated diagnosed diffuse downregulation evaluated expression homolog Hypothesis immunological MDM2 mouse neoplastic neoplastic cells overexpression p53 pathway Patient polymerase chain polymerase chain reaction real-time polymerase chain reaction retrieved Sarcoma SARS-CoV-2 SARS-CoV-2 detection sequence specimen Spread Subacute thyroiditis synergistic Thyroid thyroid dysfunction Thyroiditis Tumor tumor cell tumor cells tumor growth turn Vero E6 Vero E6 cell VERO E6 cells Viral viral particle Viral particles viral persistence Whole-genome sequence [DOI] 10.1007/s40618-021-01722-1 PMC 바로가기 [Article Type] Case Reports
Experimental Models of COVID-19COVID-19의 실험 모델Review Published on 2022-01-052022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 진단, [키워드] ACE2 receptor African African green monkeys animal model animal models balancing biosafety level cell line contribute COVID-19 COVID-19 disease different cell different cells Epidemic experimental models of COVID-19 ferret green hamster Hepatitis Human human populations humanized immortalized in vitro model In-vitro Infection Laboratory level 3 macaques mechanism MHV-1 mice mimicking Model mouse mouse hepatitis murine hepatitis virus NHPs non-human primates pandemic pathology Pneumonia Prevent primate receptor receptors Replication Research rhesus macaques robustness SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection Scientific community Spectrum susceptible therapy Transgenic mouse Transmission transmitted treat variants of concern Viral viral infection virus [DOI] 10.3389/fcimb.2021.792584 PMC 바로가기 [Article Type] Review
Animal Models of COVID-19: Transgenic Mouse ModelArticle Published on 2022-01-012022-11-15 Journal: Methods in molecular biology (Clifton, N.J.) [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome animal animal model Antiviral Brain C57BL/6 cause caused changes in concern coronavirus coronavirus disease COVID-19 COVID-19 disease cytokeratin 18 promoter death described ELISA enzyme-linked immunosorbent evaluated expressing global public health hACE2 hallmark Histopathology human Angiotensin-converting enzyme IHC immune response immunohistochemistry infected intranasally Infection K18 K18 hACE2 transgenic mice lung Lungs Model morbidity Mortality mouse mouse model nasal nervous system neutralizing monoclonal antibodies pathogenesis of SARS-CoV-2 pathogenicity pathology Prophylactic protocol respiratory tracts responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain spleen Spread survival the cytokine storm therapeutic tissues transgenic transgenic mice Treatment Vaccine viral pathogenesis viral replication virus Wuhan, China [DOI] 10.1007/978-1-0716-2111-0_16 PMC 바로가기
“But Mouse, You Are Not Alone”: On Some Severe Acute Respiratory Syndrome Coronavirus 2 Variants Infecting Mice"그러나 쥐, 당신은 혼자가 아닙니다": 쥐를 감염시키는 일부 중증 급성 호흡기 증후군 코로나바이러스 2 변종Article Published on 2021-12-312022-09-11 Journal: ILAR journal [Category] SARS, 변종, [키워드] acute respiratory syndrome adaptive AlphaFold angiotensin angiotensin-converting enzyme 2 animal reservoir Beta binding interaction Brazil complementary Contact contact with coronavirus 2 country COVID-19 Delta E484K experimental evidence F486L Gamma Haiti Human identify in silico in vitro in vivo infecting K417N lack Local methodology mice mouse mouse adaptation Mutation observation omicron Omicron variants position provide Receptor binding domain reservoir residue residues respiratory SARS-CoV-2 silico prediction silico predictions Spike protein Suriname Surveillance the spike protein unlikely variants variants of concern Venezuela virus [DOI] 10.1093/ilar/ilab031 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Variants of Concern Infect the Respiratory Tract and Induce Inflammatory Response in Wild-Type Laboratory MiceSARS-COV-2 관심의 변이체는 호흡기를 감염시키고 야생형 실험실 마우스에서 염증 반응을 유도합니다.Brief Report Published on 2021-12-242022-09-10 Journal: Viruses [Category] SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptation addition analyzed B.1 B.1 lineage B.1.1.7 B.1.351 C57BL/6 C57BL/6 mice CCL2 change chemokine chemokines Concentration concern Coronavirus-2 COVID-19 cytokine Cytokines evaluated expression greater histopathological Host host-range hosts IL-1β IL-6 Immune escape infecting Infection Inflammation inoculated intranasally lineages lung lung tissue lung tissues Lungs mice mouse mouse-adapted SARS-CoV-2 mRNA level mRNA levels multiple cytokine multiple cytokines Mutation pathogenicity public health replicated respiratory response robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the spike protein These data TNF-α tract Transmissibility upregulated variant variants of concern Viral Viral load viral nucleocapsid protein virulence virus viruses wild-type [DOI] 10.3390/v14010027 PMC 바로가기 [Article Type] Brief Report
Mechanism of Blood–Heart-Barrier Leakage: Implications for COVID-19 Induced Cardiovascular Injury혈액-심장 장벽 누출의 메커니즘: COVID-19로 인한 심혈관 손상에 대한 시사점Article Published on 2021-12-172022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] Activation acute respiratory syndrome alteration arising Blood cardiac function cardiac hypertrophy cardiovascular cause cause of death complications of COVID-19 congestive heart failure Corona virus COVID-19 COVID-19 viral myocarditis creatinine kinase isoforms death degrade Deleterious demonstrated determine dysfunction ECHO echocardiography endocardium endothelial Endothelium FITC gamut hallmark HCQ heart failure Hydroxychloroquine induced inhibit interstitium Laboratory leakage Manifestations matrix metalloproteinase matrix metalloproteinases mechanism Mfn2 mice Mitochondria mitochondrial mouse myocarditis novel corona virus Novel coronavirus phenotype Previous studies previous study respiratory Result resulting robust SARS-CoV-2 Severe acute respiratory syndrome shown Signaling subjects synchronous tissue tissue remodeling treated Treatment uncoupling variant viral myocarditis was measured were measured [DOI] 10.3390/ijms222413546 PMC 바로가기 [Article Type] Article
Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse ModelArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Analysis antiviral drug cells coronavirus coronavirus protein Coronavirus replication coronavirus RNA COVID-19 pandemic death demonstrated effective EGCG enzyme epigallocatechin examined exhibited gallate green green tea HCoV-OC43 human coronavirus OC43 in vitro in vivo infected cells Infection inhibit inhibitory effect Lungs mice Model mouse polyphenol recent reduced SARS-CoV-2 scanning electron microscopy tea Treatment virion virus production [DOI] 10.3390/v13122533 PMC 바로가기 [Article Type] Article
Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut병원체 침입 의존성 조직 저장소와 플라스미드 암호화 항생제 분해가 장내 플라스미드 확산을 촉진한다.Article Published on 2021-12-072024-07-29 Journal: eLife [Category] 살모넬라증, [키워드] Antibiotic resistance E. coli mouse Other persistence plasmids Salmonella tissue reservoirs [DOI] 10.7554/eLife.69744 PMC 바로가기
Environmental contamination with SARS-CoV-2 in COVID-19 hospitals in Wuhan, China, 20202020년 중국 우한의 COVID-19 병원에서 SARS-CoV-2로 인한 환경 오염Article Published on 2021-12-012022-09-11 Journal: Environmental microbiology [Category] SARS, 치료기술, [키워드] caused collected Contamination coronavirus disease Coronavirus disease 2019 COVID-19 death distance Effectiveness enhanced evaluate followed by hand hygiene healthcare healthcare worker Healthcare workers help hospital Hospital environment hygiene ICU Infection Infection prevention intensive care intensive care unit measure mouse pandemic positive positive rate Prevention and control quantitative PCR risk SARS-CoV-2 SARS-CoV-2 RNA the patient Transmission virus Wuhan Wuhan, China [DOI] 10.1111/1462-2920.15695 PMC 바로가기 [Article Type] Article