A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors출생 후 멜라닌 세포 계통의 유지와 멜라닌 세포 줄기 세포 전구체의 분화에서 SOX10의 이중 역할Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult stem cells appear Author cause Cell cell fate cell type Critical differentiation downregulated downstream driving embryogenesis exacerbate examined Express expression Factor growth hair hair follicle haploinsufficiency idea in vivo increased expression leads Lineage maintain maintenance mechanism Melanocyte melanocytes melanogenesis MITF mitigate Mouse models negative regulation observation overexpression pigment portion precursor Premature prevented progenitor raise regulated Regulation Regulatory role Sox10 STEM stem cell stem cells survival sustained target Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1003644 PMC 바로가기 [Article Type] Research Article
SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent MechanismResearch Article Published on 2010-04-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory syndrome affecting alveolar inflammation ARDS Author BALB/c mice caused cell proliferation clinical disease coronavirus death demonstrated Dependent died Diffuse alveolar damage ENhance Epidemic evaluated highly pathogenic I, II independent Infected Infection innate immune innate immune response Innate immunity interferon interferon signaling knockout mice lack liver Lung disease Lung injury Lung pathology MA15 mechanism mice molecular mechanism Mortality Mouse models other tissue outcomes Pathogenesis Pathways Post-infection PROTECT Protein pulmonary fibrosis pulmonary lesion question receptor regulated respiratory respiratory virus SARS Coronavirus SARS pathogenesis SARS-CoV SARS-CoV infection severe severe disease Signaling spleen Stat1 the epidemic Type type I type III interferon viral pathogenesis virus virus pathogenesis virus titer Virus-host interaction viruses weight loss wildtype [DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article