Clinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissuesResearch Article Published on 2021-08-082022-10-27 Journal: Bioengineered [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] ACE2 ACE2 expression age analyses angiotensin-converting enzyme 2 catabolic Cell cirrhosis Clinical significance coronavirus disease COVID-19 Cox regression downregulated HCC HCC patient HCC patients Hepatocellular carcinoma investigated Kaplan–Meier mechanism molecular mechanism mRNA expression pandemic potential molecular protective role SARS-COV-2 infection survival tissue was related [DOI] 10.1080/21655979.2021.1952791 PMC 바로가기 [Article Type] Research Article
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization통합 게놈 분석은 COVID-19 입원의 기저에 있는 감수성 유전자를 식별합니다Article Published on 2021-07-272022-09-12 Journal: Nature Communications [Category] 바이오마커, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] affecting Analysis association Biobank Biomarkers Clinical symptoms Coagulation contribute Control COVID COVID-19 COVID-19 hospitalization COVID-19 Host Genetics Initiative COVID-19 severity described disease severity Effect expression Genetic association study genetic loci genetics Genome-wide association studies Genome-wide association study genomic highlight Hospitalization host genetics host inflammatory response identify Immunologic individual Infection Inflammation initiative Japan mechanism mRNA expression pathway Pathways phenome predicted protein level protein levels proteome rapid progress replicate SARS-COV-2 infection severity splicing susceptibility Transcriptome viral infection with COVID-19 [DOI] 10.1038/s41467-021-24824-z PMC 바로가기 [Article Type] Article
Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by α-1 Antitrypsin †Article Published on 2021-07-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] AAT Activation activity Anti-inflammatory anti-inflammatory activity antitrypsin chemokines Combination conditions COVID-19 COVID-19 infection cytokine production Cytokines demonstrated Effects ENhance Ex vivo expressed facilitate forms host protease Human human PBMC hyper-inflammation IL-1β IL-6 IL-8 immunomodulatory activities in vitro in vivo Inflammation inhibit inhibited Interaction lipopolysaccharide LPS mononuclear cell mRNA expression oxidized Patient PBMC PBMCs Peripheral blood pro-inflammatory pro-inflammatory response Protein purified reduced SARS-CoV-2 SARS-CoV-2 spike protein severe COVID-19 significantly spike Spike protein statistical significance therapy TNF-α Treatment Trimeric spike protein viral entry [DOI] 10.3390/ijms22157941 PMC 바로가기 [Article Type] Article
Gene Expression Meta-Analysis Reveals Interferon-Induced Genes Associated With SARS Infection in LungsImmunology Published on 2021-07-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] approach association clone coronavirus CoV Culture cultures CXCL10 defined distribution enrichment FIVE Gene Expression gene set enrichment analysis gene signature gene signatures Genes GSEA highlighting human lung identify IFIT3 include Infection infections lung MERS-CoV Meta-analysis mice Middle East mRNA expression nine OAS3 OASL over-expressed overcome positive predicted public health threat reported representing respiratory Result SARS infection SARS-CoV SARS-CoV infections SARS-CoV2 SARS-CoV2 infection Significant significant enrichment strain Strains therapeutic target virus XAF1 [DOI] 10.3389/fimmu.2021.694355 PMC 바로가기 [Article Type] Immunology
Cell Analysis from Dried Blood Spots: New Opportunities in Immunology, Hematology, and Infectious DiseasesResearch Article Published on 2021-07-182022-10-28 Journal: Advanced Science [Category] COVID-19, SARS, [키워드] analyses Analysis Biomarker Biomedical research Blood blood cell buffer CD169 Cell cells cellular compartments cellular molecule common coronavirus 2 Cytometry degrade described Dried blood spots elution buffer facilitate Flow healthcare hematology implication Infection Infectious disease Laboratory leucocyte majority management mRNA mRNA expression New opportunity Patient performed permeabilized preserved Rapid red blood cell resource respiratory SARS‐CoV‐2 shaking staining Support temperature variety while [DOI] 10.1002/advs.202100323 PMC 바로가기 [Article Type] Research Article
ACE2 Is Expressed in Immune Cells That Infiltrate the Placenta in Infection-Associated Preterm BirthArticle Published on 2021-07-082022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE2 ACE2 mRNA ACE2 protein Bacterial infection Birth Blood CCL2 chorioamnionitis circulation collected COVID-19 cytokine Endothelium exhibited Express expression fetal fraction granulocyte greater healthy immune Immune cell incidence Infiltrate Lipopolysaccharide (LPS) LPS lymphocyte M1 M1/M2 macrophage M2 macrophages Macrophage monocyte Monocytes mRNA mRNA expression neutrophil Neutrophils pathway peripheral Placenta placental positive Pregnancy pregnant women Preterm birth Protein PTB risk SARS-CoV-2 SARS-CoV-2 virus second trimester TNFα Transmission treated was collected [DOI] 10.3390/cells10071724 PMC 바로가기 [Article Type] Article
Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19비강 섬모 세포는 COVID-19 초기 단계에서 SARS-CoV-2 복제의 주요 표적입니다Article Published on 2021-07-012022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 진단, 치료기술, 치료제, [키워드] addition Analysis apical side cells cellular cellular tropism ciliated ciliated cell ciliated cells COVID-19 defined early stage epithelial cells Evidence host molecule host molecules Infectious disease Molecular pathology mRNA expression nasal Nasal Epithelial cells nasal epithelium pathology patients with COVID-19 precursor Prevent protein level protein levels replaced REPLACED BY replicated respiratory SARS-CoV-2 SARS-CoV-2 propagation SARS-CoV-2 replication single-cell squamous epithelium target upper respiratory tract [DOI] 10.1172/JCI148517 PMC 바로가기 [Article Type] Article
RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses중증 급성 호흡기 증후군 코로나바이러스-2의 바이러스 게놈 RNA의 RIG-I 유사 수용체 매개 인식 및 숙주 선천 면역 반응으로부터의 바이러스 탈출Immunology Published on 2021-06-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antiviral responses caused CCL5 coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 cytokine cytokine expression cytoplasmic destabilized epithelial cell epithelial cells escape expression fragment of genomic RNA Host host response human cells IFN-β immune responses in some induce infected cells inhibited Innate innate immune response innate immune responses Innate immunity Interaction involved IP-10 knockout MAVS MDA5 mechanism mRNA expression pandemic Particle Phosphorylation Protein Recognition recognize Region required respiratory response RIG-I RIG-I-like receptor RIG-I-like receptors RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell SARS-CoV-2-infected cells Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 TBK1 total RNA total RNAs transfection Trigger Type I IFN type I interferon Viral viral double-stranded RNA viral escape Viral RNA was reduced [DOI] 10.3389/fimmu.2021.700926 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in MacrophagesImmunology Published on 2021-06-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor Activation Anti-inflammatory anti-inflammatory response CD14+ monocytes Cell cell type chemokines COVID-19 COVID-19 patients CXCL5 cytokine Cytokine storm Cytokines death demonstrated Engagement enzyme examined expression had no human macrophage human PBMC IL-6 IL6 IL8 inactive induce infect Inflammation inflammatory mediator Inflammatory response initiate innate immune system Interaction IRAK-M isoform LPS-activated lung Macrophage macrophages magnitude modulate mRNA mRNA expression mRNA levels PBMCs pro-inflammatory pro-inflammatory cytokine Production promoted Protein protein expression protein level receptor regulated SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 S SARS-CoV-2 S protein shown stimulated suppressed therapeutic strategy THP-1 TLR TLR ligand TNFα treated Treatment [DOI] 10.3389/fimmu.2021.683800 PMC 바로가기 [Article Type] Immunology
Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccineArticle Published on 2021-06-162022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Activation Analysis Biomarker Cell dendritic cell differentially expressed domains eight facilitated Gene regulation in immune cells homology immune responses in vivo inactivated Inactivated vaccine increased expression Infectious Bronchitis Virus Innate immune cells lipid metabolism lysed maturation mRNA mRNA expression mRNA translation newcastle disease virus PLIN2 positive control Potential biomarker Protein protein level Proteins proteomic Proteomic analysis provide PSMB1 significantly stimulated Stimulation subject the vaccine upregulated Vaccine vaccine-induced immune responses Vaccines were assessed [DOI] 10.1038/s41598-021-89810-3 PMC 바로가기 [Article Type] Article