Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19혈청 신경섬유 경단백질은 COVID-19로 입원한 환자의 불리한 임상 결과와 상관관계가 있습니다Report Published on 2021-07-142022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 바이오마커, [키워드] addition Analysis analyzed brain damage Brain imaging cause Clinical outcome clinical outcomes Cohort Concentration coronavirus disease Coronavirus disease 2019 correlated COVID-19 Determining disease disease severity elevated evaluate evaluated Evidence evidence of expression healthy controls hospitalized patient hospitalized patients imaging Injury lesion lesions leukoencephalopathy light chain marker neurological neurological manifestation neurological manifestations neuronal outcome pathophysiology patients patients hospitalized patients with COVID-19 potential therapies predict proportion Prospective Study Protein reduced Remdesivir risk SARS-COV-2 infection Selection bias serum subject therapeutic therapeutic trials These data treated Trial White matter with COVID-19 [DOI] 10.1126/scitranslmed.abi7643 PMC 바로가기 [Article Type] Report
Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19Neuroscience Published on 2021-07-052022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] ACE2 alternative route animal model antibody Brain Brain infection bulb express cathepsin Cell CHAT Consensus COVID-19 enzyme examined expressed fraction GnRH human tissues majority mice nasal epithelium nervus nervus terminalis Neuron neuronal neurons obligatory olfactory Olfactory epithelium olfactory receptor neurons Olfactory system Potential previous study receptor route SARS-CoV-2 suggested target targets Terminalis the SARS-CoV-2 virus the timing transfer virus virus entry [DOI] 10.3389/fncel.2021.674123 PMC 바로가기 [Article Type] Neuroscience
Possible Link between SARS-CoV-2 Infection and Parkinson’s Disease: The Role of Toll-Like Receptor 4SARS-CoV-2 감염과 파킨슨병 사이의 가능한 연관성: 유료 유사 수용체 4의 역할Review Published on 2021-07-012022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] accumulation Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation binding causative agent cerebrovascular diseases characterized conscious coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient death Depletion disease Dopamine Evidence Factor hallmark immune immune response include individual Inflammatory response Interaction mechanism midbrain motor disorder Mounting neurodegenerative Neuroinflammation neurological manifestations Neuron neuronal neurotropic pandemic coronavirus Parkinson’s disease Parkinson’s disease Parkinsonism Pathogenesis pathway patients with COVID-19 Precipitation Protein reported respiratory responsible role SARS-CoV-2 SARS-CoV-2 spike selective severe acute respiratory syndrome Coronavirus signaling pathway subsequent substantia substantia nigra Symptom synuclein TLR4 TLRs Toll-like receptor toll-like receptor 4 Toll-like receptors Viral viral infection virus entry [DOI] 10.3390/ijms22137135 PMC 바로가기 [Article Type] Review
Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective studyCOVID-19 환자의 중대 질환 다발신경병증, 근육병증 및 신경 바이오마커: 전향적 연구Observational Study Published on 2021-07-012022-09-11 Journal: Clinical neurophysiology : official journal of the [Category] MERS, 바이오마커, 임상, 진단, [키워드] Acidic Adult patients amplitudes Biomarker Characteristics cohort study coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness Critical illness neuropathy Critical illness polyneuropathy develop early phase feature GFAp had more ICU ICU care ICU patient ICU Patients intensive care intensive care unit invasive ventilation light chain Myopathy neurofilament neuronal Neuropathy NfL Non-COVID-19 non-COVID-19 cohort Patient plasma biomarker Polyneuropathy Predictive prevalent Prospective Study Protein SARS-CoV-2 significantly higher thromboembolic Thromboembolic event treated Uppsala Uppsala University weakness [DOI] 10.1016/j.clinph.2021.03.016 PMC 바로가기 [Article Type] Observational Study
The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: ReviewReview Published on 2021-06-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome analgesic effect Angiogenesis appear association bind Central nervous system coronavirus coronavirus disease COVID-19 database facilitate functions glycoprotein host cell host cell membrane host cell receptor immune responses implicated Infection inhibitor interact literature nasal neurological manifestation neuronal Neuropilin-1 NRP-1 Olfactory epithelium pandemic pathological change Protein receptor Regulation responsible Retina review role SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection significantly Spread subunit therapeutic strategy Treatment virus was used [DOI] 10.3390/jcm10132772 PMC 바로가기 [Article Type] Review
C-type lectins and extracellular vesicles in virus-induced NETosisReview Published on 2021-06-112022-10-29 Journal: Journal of Biomedical Science [Category] COVID-19, MERS, SARS, [키워드] activate acute respiratory syndrome acute viral infections attenuate blockade C-type lectin C-type lectin receptor (CLR) caused CLEC10A CLEC2 CLEC5A Coagulopathy contribute Coronavirus-2 COVID-19 Cytokine storm danger signals DC-SIGN dengue virus Dengue virus (DV) disease severity ENhance EVs exacerbate Exosome Exosome (EXO) extracellular vesicle Extracellular vesicle (EV) facilitate glycan Inflammation inflammatory reactions intercellular Japanese L-SIGN microvesicle Microvesicle (MV) NET NETosis NETs neuronal Neutrophil extracellular trap organ Pathogenesis Patient pattern recognition receptor Platelet receptor reported responsible SARS-CoV-2 shown spleen stimulate TLR TLR2 tyrosine virus [DOI] 10.1186/s12929-021-00741-7 PMC 바로가기 [Article Type] Review
Herpes Simplex Virus 1 Infection of Neuronal and Non-Neuronal Cells Elicits Specific Innate Immune Responses and Immune Evasion MechanismsReview Published on 2021-05-312024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] alphaherpesvirus cGAS-STING pathway HSV-1 IFN - interferon Innate immunity latency neuronal TLR - toll-like receptor [DOI] 10.3389/fimmu.2021.644664 PMC 바로가기 [Article Type] Review
Brainstem neuropathology in two cases of COVID-19: SARS-CoV-2 trafficking between brain and lungCOVID-19의 두 가지 사례에서 뇌간 신경병리학: 뇌와 폐 사이의 SARS-CoV-2 트래피킹Case Reports Published on 2021-05-182022-09-10 Journal: Journal of Neurology [Category] SARS, 치료기술, [키워드] abnormality Activation Anatomy Antigen Autopsies Brain Brainstem brainstem reflex cells controls COVID-19 COVID-19 negative COVID-19 patients cranial cranial nerves demonstrated died element Evidence exhibited expression feature glial cells histopathological examination immunohistochemistry include increase in lung material Medulla oblongata negative patients nervous system Neurological COVID-19 Neuron neuronal Neuropathology oblongata Other pathophysiology Patient reported respiratory centers Respiratory failure Result SARS-Co SARS-CoV-2 SARS-CoV-2 nucleoprotein Spread supplementary material the SARS-CoV-2 two COVID-19 patients two patients vagus nerve Viral widespread [DOI] 10.1007/s00415-021-10604-8 PMC 바로가기 [Article Type] Case Reports
Longitudinal in vivo imaging of acute neuropathology in a monkey model of Ebola virus infectionArticle Published on 2021-05-172022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] albumin Apoptosis baseline Brain cause Cell death in the nervous system Central nervous system change CNS contrast material cytokine level disease Disease progression Ebola Ebola virus Ebola virus infection Effect Efficacy endothelial expression extracellular space Glucose GLUT3 help immunohistochemistry in vivo Increased longitudinal marker metabolism Mild Neuroimaging Neuroinflammation neurological Neurological symptom neuronal neuronal infection non-human primate model pathological change pathophysiology pet Quantitative real time viral infection Viral load [DOI] 10.1038/s41467-021-23088-x PMC 바로가기 [Article Type] Article
Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromesOriginal Article Published on 2021-05-122022-10-27 Journal: Brain Communications [Category] COVID-19, [키워드] Acidic Activation ADEM Biomarker cerebrospinal fluid characterized CNS collected Community Concentration Control control groups correlation COVID-19 CSF elevated Encephalitis Encephalopathy Guillain–Barrè syndrome hospitalized patient Increased individual Inflammation marker nerve damage nervous system Neuroinflammation neurological neurological manifestations neuronal NfL Patient patients hospitalized patients with COVID-19 profile Protein SARS-CoV-2 SARS-COV-2 infection serum significantly syndrome with COVID-19 [DOI] 10.1093/braincomms/fcab099 PMC 바로가기 [Article Type] Original Article