Simplified dolutegravir dosing for children with HIV weighing 20 kg or more: pharmacokinetic and safety substudies of the multicentre, randomised ODYSSEY trial체중이 20kg 이상인 HIV가 있는 소아에 대한 단순 돌루테그라비르 투여: 다기관, 무작위 ODYSSEY 시험의 약동학 및 안전성 하위 연구Article Published on 2020-08-042022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] (coefficient of variation (cryptococcal meningitis Adults adverse event adverse events AIDS approval approved Asymptomatic baseline children coefficient Coefficient of variation Concentration concentration-time curve cryptococcal meningitis dolutegravir dose dosed doses drug enrolled estimate European evaluate evaluated finding follow-up period food foundation funding geometric geometric mean highest HIV less Medical Research Council Meningitis multicentre network neutropenia ODYSSEY once daily Open-label over Patient pharmacokinetic pharmacokinetic data plasma profile randomised reference values regulatory authority reported required Research SRA subject Tablet tablets target the WHO Treatment Trial Uganda Variation was done weighed with HIV Zimbabwe [DOI] 10.1016/S2352-3018(20)30189-2 PMC 바로가기 [Article Type] Article
ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of hyperthyroidism and hypothyroidismClinical Practice Guidance Published on 2020-07-192022-10-31 Journal: European Journal of Endocrinology [Category] COVID-19, SARS, [키워드] Antithyroid drug ATD biochemical clinics COVID-19 COVID-19 pandemic diagnosed Diagnosis diagnostic disease dosage dysfunction Guidance hormone Hypothyroidism increased risk Infection initial management manifestation manuscript medication neutropenia neutrophil Patient Pregnancy presenting progression provide regimen SARS-COV-2 infection selected severe complication supported symptoms of infection Thyroid thyrotoxicosis Treatment uncontrolled with COVID-19 Withdrawal [DOI] 10.1530/EJE-20-0445 PMC 바로가기 [Article Type] Clinical Practice Guidance
Efficacy of hydroxychloroquine for post-exposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among adults exposed to coronavirus disease (COVID-19): a structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 access acute respiratory syndrome addition age anticipated assigned Asymptomatic Baltimore baseline blinded blocked Bone marrow Boston Care Chloroquine clinically suspected close contact Complete Compound Concomitant concomitant use conducted Contact coronavirus coronavirus disease cough COVID-19 criteria current Date defined determine Diagnosis disorder dissemination Efficacy element eligible eligible participant etiology excluded first dose HCQ Health care worker healthcare worker history Hospitalized household household contact Hydroxychloroquine hypersensitivity incidence index case Infection Intervention leukocyte Los Angele medication moderate multisite neutropenia New Orlean New York City number objective outcome participant PCR-confirmed Pharmacist polymerase chain polymorphonuclear Post-exposure prophylaxis Prevent Primary outcome prolonged exposure Prophylaxis protocol psoriasis randomised randomised controlled trial randomization Randomized receive receiving Registered registry renal impairment responders resulting Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR test Seattle Secondary objective Seven severe liver disease Shortness of breath statistical statistician stratified study drug study period Study protocol subjective fever syndrome Tamoxifen telehealth therapy Tolerability Treatment Trial Vaccine virus website women [DOI] 10.1186/s13063-020-04446-4 PMC 바로가기 [Article Type] Letter
Neonates Hospitalized with Community-Acquired SARS-CoV-2 in a Colorado Neonatal Intensive Care UnitCase Reports Published on 2020-01-012023-07-05 Journal: Neonatology [Category] SARS, [키워드] COVID-19 Neonate neutropenia SARS-CoV-2 [DOI] 10.1159/000508962 PMC 바로가기 [Article Type] Case Reports
Hepatotoxicity and hematologic complications induced by fusidic acid in a patient with hepatitis B cirrhosis A case reportArticle Published on 2019-11-112023-06-03 Journal: Medicine [Category] B형 간염, [키워드] adverse effect fusidic acid jaundice neutropenia thrombocytopenia [DOI] 10.1097/MD.0000000000017852 PMC 바로가기
Changes in total and differential leukocyte counts during the clinically silent liver phase in a controlled human malaria infection in malaria-naïve Dutch volunteers임상적으로 침묵하는 간 단계에서 말라리아에 면역이 없는 네덜란드 자원봉사자들에 대한 통제된 인간 말라리아 감염 중 총 백혈구 수와 차등 백혈구 수의 변화Research Published on 2017-11-102024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] Controlled human malaria infection Leukocyte count Liver phase Lymphocyte count lymphocytopenia Monocytes neutropenia Neutrophil to lymphocyte count ratio Plasmodium falciparum [DOI] 10.1186/s12936-017-2108-1 PMC 바로가기 [Article Type] Research
Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents, and young adults (BREATHER): a randomised, open-label, non-inferiority, phase 2/3 trialHIV에 감염된 어린이, 청소년 및 젊은 성인(BREATHER)에 대한 주말 휴무 에파비렌즈 기반 항레트로바이러스 요법: 무작위, 공개, 비열등성, 2/3상 시험Articles Published on 2016-06-202022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 abortion adherent adverse event African age Antiretroviral therapy ART assigned block BREATHER CD4 cell Cell children clinician computer-generated country CTA Dizziness drug efavirenz eligible participant Eligible participants EudraCT European European Commission event finding FIVE France funding grade 3 gynaecomastia headache HIV-1 ideation inferiority inhibitors Intention intention to treat IQR ISRCTN Kaplan-Meier method less life Lipodystrophy list median median age Medical Research Council men neutropenia non-inferiority non-inferiority margin non-inferiority trial nucleoside occurred offer Open-label participant Patient phase 2/3 trial Primary outcome proportion raised randomisation randomisation list randomised Randomly reached Registered reverse transcriptase RNA safety profile Seven shown spontaneous abortion stratified Suicidal ideation Syncope technology Technology assessment the Kaplan-Meier method therapy Toxicity transaminases transcriptase Trial Viral Viral load virological suppression was done web service [DOI] 10.1016/S2352-3018(16)30054-6 PMC 바로가기 [Article Type] Articles
Frequent Respiratory Viral Infections in Children with Febrile Neutropenia – A Prospective Follow-Up StudyResearch Article Published on 2016-06-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] age Chemotherapy children collected Comparisons coronavirus determine febrile neutropenia Fever Fisher’s exact test Follow-up Frequency genotyped infections majority malignancies Mann-Whitney U test median nasopharyngeal aspirate neutropenia objective oncology Patient patient cohorts polymerase chain positive Prospective resolved respiratory respiratory viral infection respiratory virus respiratory viruses Result rhinovirus Sequencing subject tested treated Treatment virus was used were used [DOI] 10.1371/journal.pone.0157398 PMC 바로가기 [Article Type] Research Article
Pathogenesis of fulminant monkeypox with bacterial sepsis after experimental infection with West African monkeypox virus in a cynomolgus monkeyCase Reports Published on 2014-06-152023-06-09 Journal: International journal of clinical and experimental pathology [Category] 원숭이두창, [키워드] animal model cynomolgus monkey cytokine Monkeypox neutropenia PMC 바로가기 [Article Type] Case Reports
Effect of High-Dose or Split-Dose Artesunate on Parasite Clearance in Artemisinin-Resistant Falciparum Malaria고용량 또는 분할 용량 아르테순산이 아르테미시닌 내성 팔시파룸 말라리아의 기생충 제거에 미치는 영향Article Published on 2013-03-012024-08-13 Journal: Clinical infectious diseases : an official publication of the Infectious [Category] 말라리아, [키워드] artemisinins drug resistance neutropenia Plasmodium falciparum reticulocytopenia [DOI] 10.1093/cid/cis958 PMC 바로가기