Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-κB pathway in porcine intestinal epithelial cell lineResearch Article Published on 2018-10-122022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] activate Activation Analysis analyzed binding cell line cells circular RNA differentially expressed Effects epithelial epithelial cell line expressed gastroenteritis Infection Inflammation inhibited Interaction intestinal intestinal epithelial cell KEGG Kyoto microRNA miRNA miRNAs mitochondrial mRNA mRNAs ncRNA ncRNAs Next-generation sequencing NF-κB NF-κB pathway NGS non-coding RNA nucleus opposite overexpression p65 pathway Pathways Phosphorylation profile promoted Protein receptor reduction regulate reporter Result RNA severe inflammation supplementary material TGEV TNF translated transmissible gastroenteritis virus viral infection virus was used [DOI] 10.1186/s12864-018-5128-5 PMC 바로가기 [Article Type] Research Article
Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan ChildrenlincRNA의 다형성이 케냐 어린이의 폐렴구균 균혈증 위험 2배와 연관Article Published on 2016-05-262022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, 폐렴구균 감염증, [키워드] 95% CI African Associate association Bacteremia bacteremia case subject bacteremia susceptibility bacterial bloodstream infection Cell cell type children conducted Control control subject control subjects death expression focus Frequency Genome-wide association study healthy Human genetics human infectious disease identification Infant Infectious disease Kenya lincRNA low frequency Neutrophils non-coding RNA occur pneumococcal bacteremia pneumococcal clearance polymorphism Polymorphisms recruited replicated Research Streptococcus pneumoniae sub-Saharan Africa subjects susceptibility susceptibility allele Wellcome Trust [DOI] 10.1016/j.ajhg.2016.03.025 PMC 바로가기 [Article Type] Article
Dual regulatory effects of non-coding GC-rich elements on the expression of virulence genes in malaria parasitesarticle Published on 2015-12-312024-09-01 Journal: Infection, Genetics and Evolution [Category] 말라리아, [키워드] GC-elements malaria mutually exclusive expression non-coding RNA Plasmodium falciparum var genes [Article Type] article
Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum뉴클레오솜 위치 분석은 인간 말라리아 기생충인 플라스모디움 팔시파룸에서 유전자 발견을 가능하게 한다.Methodology Article Published on 2015-11-252024-08-13 Journal: BMC Genomics [Category] 말라리아, [키워드] gene prediction genome annotation malaria non-coding RNA Nucleosome Transcription [DOI] 10.1186/s12864-015-2214-9 PMC 바로가기 [Article Type] Methodology Article
Characterisation of novel microRNAs in the Black flying fox ( Pteropus alecto ) by deep sequencingResearch Article Published on 2014-08-152023-08-29 Journal: BMC Genomics [Category] E형 간염, [키워드] bats Chiroptera microRNA non-coding RNA Pteropus alecto Transcriptome [DOI] 10.1186/1471-2164-15-682 PMC 바로가기 [Article Type] Research Article
Variations in ncRNA gene LOC284889 and MIF-794CATT repeats are associated with malaria susceptibility in Indian populationsncRNA 유전자 LOC284889 및 MIF-794CATT 반복의 변이는 인도 인구에서 말라리아 감수성과 관련이 있다.Research Published on 2013-09-252024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Diplotype Indian populations malaria MIF non-coding RNA polymorphism [DOI] 10.1186/1475-2875-12-345 PMC 바로가기 [Article Type] Research
miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction [DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article
Identification and Characterization of Three Novel Small Interference RNAs That Effectively Down-Regulate the Isolated Nucleocapsid Gene Expression of SARS CoronavirusArticle Published on 2011-02-112022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] analyzed Apoptosis cells characterization coding sequence conserved coronavirus different eGFP Evidence expression found function Gene Expression Host host cell identification IFNβ inhibitory effect innate immune responses Interference interferon Isolated isolates M gene N gene non-coding RNA novel Nucleocapsid gene nucleotide deletion post-transcriptionally Proinflammatory cytokine Protein reduce Region RNA RT-PCR SARS-CoV sequence sequence information significantly siRNA Substitution thought up-regulate [DOI] 10.3390/molecules16021544 PMC 바로가기 [Article Type] Article