ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular ResponseApoE-Isoform-Dependent SARS-CoV-2 Neurotropism 및 세포 반응Article Published on 2021-02-042022-09-11 Journal: Cell Stem Cell [Category] Fulltext, MERS, 진단, 치료제, [키워드] Alter Alzheimer disease Alzheimer's disease ApoE APOE4 Astrocyte astrocytes Brain brain organoids Cell co-culture COVID-19 COVID-19 severity COVID-19 susceptibility Culture cultures direct viral infection Effect elevated exhibited genetic risk factor help increased risk induced pluripotent stem cells Infection inhibit iPSCs Neuron neuron-astrocyte co-culture neurons nuclear fragmentation organoids Patient pluripotent stem cells populations Remdesivir response risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neurotropism SARS-CoV2 SARS-CoV2 infection severe COVID-19 severity stem cell tested Treatment understanding Viral viral infection [DOI] 10.1016/j.stem.2020.12.018 PMC 바로가기 [Article Type] Article
Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids인간 유도 만능 줄기 세포 유래 망막 오르가노이드에서 내인성 안지오텐신 전환 효소 2의 발현Article Published on 2021-01-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 expression ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture cultures endogenous entry of SARS-CoV-2 enzyme Evidence Express expression eye eyes GFP host cell host cell receptor Human immunofluorescence staining in some induced induced pluripotent stem cells Infection monolayer cultures mRNA level nervous tissues Neuron Organoid organoids patients protein expression pseudovirus reported respiratory Retina Retinal retinal organoid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus Serine severe acute respiratory syndrome Coronavirus Spike protein STEM stem cell subsequent target tissue the SARS-CoV-2 tissue TMPRSS2 transmembrane serine protease transmembrane serine protease 2 [DOI] 10.3390/ijms22031320 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic InfectionReview Published on 2021-01-132023-06-14 Journal: Clinical microbiology reviews [Category] MERS, SARS, [키워드] coronavirus COVID-19 disease Infection organoids organs SARS-CoV-2 systemic [DOI] 10.1128/CMR.00133-20 PMC 바로가기 [Article Type] Review
Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infectionSARS-CoV-2 감염 시 인간의 기도 및 폐포 오르가노이드에서 숙주 대사 조절 장애 및 세포 친화성 식별Research Article Published on 2020-12-122022-09-10 Journal: Protein & Cell [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition airway alveolar animals AT2 Cancer cells caused Cell cell line cell lines cell tropism cells cellular metabolism ciliated club Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture distal downregulation Drug discovery dysregulation embryonic embryonic stem cells human airway human lung organoid human lung organoids humans immune response in vitro infect infected cell infected cells Infection inhibited lipid metabolism lung organoids Lungs mechanism metabolic processes metabolism neutralizing antibody Organoid organoids organs pandemic pathophysiological physiological condition physiological conditions proximal Remdesivir replicated respiratory respiratory droplet Respiratory droplets RNA-Seq route SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Spread stem cell supplementary material therapeutic drug upregulation virus infection [DOI] 10.1007/s13238-020-00811-w PMC 바로가기 [Article Type] Research Article
3D culture models to study SARS-CoV-2 infectivity and antiviral candidates: From spheroids to bioprintingReview Article Published on 2020-11-212023-07-01 Journal: Biomedical journal [Category] SARS, [키워드] 3D bioprinting COVID-19 organoids SARS-CoV-2 tissue engineering [DOI] 10.1016/j.bj.2020.11.009 PMC 바로가기 [Article Type] Review Article
Bioengineered in Vitro Tissue Models to Study SARS-CoV-2 Pathogenesis and Therapeutic ValidationReview Published on 2020-11-162023-06-15 Journal: ACS Biomaterials Science & Engineering [Category] MERS, SARS, [키워드] 3D bioprinting in vitro model organoids SARS-CoV-2 tissue engineering vaccine trial [DOI] 10.1021/acsbiomaterials.0c01226 PMC 바로가기 [Article Type] Review
Organoid based personalized medicine: from bench to bedsideReview Published on 2020-11-022022-10-31 Journal: Cell Regeneration [Category] COVID-19, [키워드] accumulating addition application Biobanks Cancer CRISPR-Cas9 disease modeling Diseases Evidence fibrosis Genetic in vitro in vivo malignant diseases Organoid organoids organs Personalized medicine phenotypic pluripotent stem cell regenerative Research stem cell stem cells tissues translational [DOI] 10.1186/s13619-020-00059-z PMC 바로가기 [Article Type] Review
Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte DysfunctionArticle Published on 2020-10-212023-06-14 Journal: Cell Stem Cell [Category] MERS, SARS, [키워드] ACE2 ARDS Cytokine storm interferons organoids Pneumocytes protease respiratory cells SARS-CoV-2 surfactants [DOI] 10.1016/j.stem.2020.10.005 PMC 바로가기 [Article Type] Article
Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus InfectionCommunication Published on 2020-09-122022-10-31 Journal: Cells [Category] Coronavirus, [키워드] Cell culture Colon Combination coronavirus Culture demonstrated develop development Factor FECV Feline coronavirus feline enteric coronavirus Feline infectious peritonitis virus feline intestinal organoids FIPV Gut ileum infect Infection isolate Mild molecular mechanism Mutation Organoid organoids persistence Population Potential Support virus [DOI] 10.3390/cells9092085 PMC 바로가기 [Article Type] Communication
Regen med therapeutic opportunities for fighting COVID ‐19Perspectives Published on 2020-08-272022-10-28 Journal: Stem cells translational medicine [Category] COVID-19, MERS, [키워드] animal model animal models COVID COVID‐19 COVID‐19 drug evaluate help highlight identify lung mechanism of action Medicine mesenchymal stromal/stem cells organ systems organoids pandemic patients Perspective physiological platform regenerative regenerative medicine resource SARS‐CoV‐2 SARS‐CoV‐2 Scientific community Society therapeutic therapy virus [DOI] 10.1002/sctm.20-0245 PMC 바로가기 [Article Type] Perspectives