Brief Educational Video plus Telecare to Enhance Recovery for Older Emergency Department Patients with Acute Musculoskeletal Pain: an update to the study protocol for a randomized controlled trial급성 근골격 통증이 있는 고령 응급실 환자의 회복을 향상시키기 위한 간단한 교육 비디오와 텔레케어: 무작위 대조 시험을 위한 연구 프로토콜 업데이트Article Published on 2022-05-122022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] addition Care change chronic pain Consent COVID-19 pandemic Department eligibility criteria Emergency emergency medicine Enrollment expansion Generalizability Geriatrics Hospitalization in some include inclusion criteria individual Musculoskeletal Musculoskeletal pain occur opioid orthopedic Other outcomes Pain pandemic presenting protocol randomization Randomized controlled trial recruitment seeking Shared decision-making Study protocol Symptom Treatment Trial [DOI] 10.1186/s13063-022-06310-z PMC 바로가기 [Article Type] Article
Binding Interactions between Receptor-Binding Domain of Spike Protein and Human Angiotensin Converting Enzyme-2 in Omicron Variant오미크론 변이체에서 스파이크 단백질의 수용체 결합 도메인과 인간 안지오텐신 전환 효소-2 간의 결합 상호작용Article Published on 2022-05-052022-09-11 Journal: The journal of physical chemistry letters [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Affect angiotensin Antibody neutralization bind conformational changes contagious COVID-19 pandemic decrease distribution electrostatic interactions exacerbated Human K417N molecular molecular dynamics Mutation mutations N501Y new SARS-CoV-2 omicron Other predicted RBD RBD mutation Receptor-binding domain resulting S-protein spike Spike protein Strains systematic analysis T478K the receptor-binding domain the spike protein Transmissibility variant [DOI] 10.1021/acs.jpclett.2c00423 PMC 바로가기 [Article Type] Article
Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)SARS-CoV-2 백신 부스터 후 2주간 저용량 메토트렉세이트 치료를 일시적으로 중단하는 것이 염증성 질환이 있는 면역억제 성인의 백신 반응에 미치는 영향: 다기관 무작위 대조 시험 및 중첩 기전 하위 연구 프로토콜(Vaccine Response On/Off Methotrexate(VROOM) ) 공부하다)Article Published on 2022-05-032022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 adjusted Analysis Anti-spike antibody approved Arm ARMS assessment Autoimmune B-cell baseline biochemical booster booster vaccination clinical trials clinics collected conducted conferences COVID-19 Dermatology disease Disease activity domain Effect ENhance Ethics ethics committee evaluate Factor feasibility group Health Research Authority immune response Immunosuppressed IMPROVE Inflammatory inflammatory conditions Intention intention to treat Intervention investigated IRAS low-dose main outcome measure memory methotrexate multicentre neutralising antibody titre Open-label Other parallel group participant Participants Patient peer review performed Pragmatic Primary outcome protocol randomisation randomised randomised controlled randomised controlled trial RBD REC registration number repeated measure repeated measures required Research Ethics response Result rheumatology Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine secondary outcome secondary outcome measure subject T-cell Response Treatment Trial UK hospitals usual care vaccination against COVID-19 vaccine response West written Informed Consent [DOI] 10.1136/bmjopen-2022-062599 PMC 바로가기 [Article Type] Article
Immunogenicity of BNT162b2 vaccine against the Alpha and Delta variants in immunocompromised patients with systemic inflammatory diseases전신 염증성 질환이 있는 면역 저하 환자에서 알파 및 델타 변이체에 대한 BNT162b2 백신의 면역원성Article Published on 2022-05-012022-09-11 Journal: Annals of the rheumatic diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] abrogated Alpha alpha and delta variants analysed anti-spike antibodies anti-spike antibody anti-Spike IgG B-cell B.1.617.2 BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections Control controls COVID-19 Delta delta variant Delta variants dose effort Endpoint evaluate exhibiting healthcare humoral Humoral response Immune escape immunocompromised individual immunocompromised individuals Immunocompromised patient Immunocompromised patients immunogenicity impairing IMPROVE individual infected with SARS-CoV-2 Inflammatory diseases Kinetics methotrexate mounted neutralisation neutralising Neutralising activity of BNT162b2 Other Patient primary endpoints Prospective raise regimen responses rituximab SARS-CoV-2 secondary Secondary endpoints sera Seroconversion Specific T-cell response strain Strains Support systemic inflammatory disease systemic inflammatory diseases T-cell T-cell Response T-cell responses therapeutic treated vaccination Vaccine Viral viral fitness [DOI] 10.1136/annrheumdis-2021-221508 PMC 바로가기 [Article Type] Article
The Effect of Convalescent Plasma in Patients With Covid-19 in Intensive Care UnitObservational Study Published on 2022-05-012022-10-04 Journal: In vivo (Athens, Greece) [Category] COVID19(2023년), SARS, 임상, [키워드] addition age antibody antiviral activity clinical collected Comorbidity convalescent convalescent plasma convalescent plasma treatment COVID-19 COVID-19 patient CRP Effect Emergency Evolution Factor fibrinogen form high-flow oxygen therapy Hospitalization Hyperimmune plasma hyperimmune plasma. immunological mechanism Infection Inflammatory marker intensive care unit marker non-invasive ventilation Other outcome pathophysiological Patient plasma positive RT-PCR Receptor binding domain reducing responsible retrospective Romania SARS-CoV-2 significantly Standard therapy supplemental oxygen survivor the disease therapy therapy for COVID-19 treated ventilatory parameter was reduced [DOI] 10.21873/invivo.12836 PMC 바로가기 [Article Type] Observational Study
Changes and Inequities in Adult Mental Health-Related Emergency Department Visits During the COVID-19 Pandemic in the US미국의 COVID-19 팬데믹 기간 동안 성인 정신 건강 관련 응급실 방문의 변화와 불평등Article Published on 2022-05-012022-09-11 Journal: JAMA Psychiatry [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI accounting affected Alaska Analysis Anxiety Asian bipolar black change changes in circulation compulsive COVID-19 COVID-19 case COVID-19 pandemic cross-sectional cross-sectional study declined deficit Delta delta variant Department depressive disorder disorders eating disorders Emergency emergency department Ethnicity fluctuation fluctuations group Health Hispanic hyperactivity identify Increases increases in Mental disorder Mental Disorders mental health MOST Native negatively affected Other outcome pandemic Practitioner Program proportion Public Racial Result Schizophrenia selected stability Stressor subpopulations TIC Tic disorders trauma Variation Volume white women [DOI] 10.1001/jamapsychiatry.2022.0164 PMC 바로가기 [Article Type] Article
Risk factors associated with household transmission of SARS-CoV-2 in Negeri Sembilan, MalaysiaObservational Study Published on 2022-05-012022-10-05 Journal: Journal of paediatrics and child health [Category] COVID19(2023년), SARS, 임상, [키워드] Analysis calculated conducted COVID-19 COVID-19 case epidemiological Factor greater household household contact household contacts household transmission identify increased risk independent risk factor index case Logistic regression Malaysia male median age Negeri Sembilan Other resulting retrospective risk risk factor SARS-CoV-2 secondary attack rate secondary case Secondary infection secondary infections significantly socio-demographic symptomatic Transmission Transmission dynamics transmission of SARS-CoV-2 were used [DOI] 10.1111/jpc.15821 PMC 바로가기 [Article Type] Observational Study
Personality, gender, and age resilience to the mental health effects of COVID-19Research article Published on 2022-05-012022-10-05 Journal: Social science & medicine (1982) [Category] 유전자 메커니즘, [키워드] adaptive affected age assist can be used Characteristics Cohort COVID-19 COVID-19 pandemic Critical Effect event extroversion fixed Gender help identify Impact increase in individual individuals knowledge loneliness Longitudinal data Mental mental health objective occur Other pandemic Personality promote Psychological Psychological distress public health rationale Resilience response Result Support Symptom traits understanding worsening young adults [DOI] 10.1016/j.socscimed.2022.114884 [Article Type] Research article
Oxygen-Free Days as an Outcome Measure in Clinical Trials of Therapies for COVID-19 and Other Causes of New-Onset HypoxemiaReview article Published on 2022-04-302022-10-05 Journal: Chest [Category] 임상, 치료제, [키워드] acute lung injury adults hospitalized cause clinical clinical trial clinical trials consequence COVID-19 COVID-19 pandemic Critical care Day detect evaluate greater hospitalized patient host response Hypoxemia hypoxemic limit lung lung dysfunction measure morbidity Mortality Other outcome outcomes oxygen performed platform Population populations power Prevalence Primary outcome provide recognize reducing Respiratory failure Sample size sample size calculation supplemental oxygen therapy Trial Ventilator-free days with COVID-19 [DOI] 10.1016/j.chest.2022.04.145 [Article Type] Review article
Learning from COVID-19 related trial adaptations to inform efficient trial design-a sequential mixed methods study효율적인 시험 설계를 알리기 위해 COVID-19 관련 시험 적응에서 학습 - 순차적 혼합 방법 연구Review Published on 2022-04-292022-09-11 Journal: BMC Medical Research Methodology [Category] 임상, [키워드] adaptation Administered barrier benefit clinical clinical trial clinical trials concerning Consent COVID-19 COVID-19 pandemic Efficiency efficient Efficient trial design eligibility assessment Evidence flexibility Follow-up identify IMPROVE include Intervention delivery investigated lack learning limitation literature review methodology NHS not seen Other pandemic participant Patient recruitment Registered selected Support supported SWAT tested Trial Trial methodology Trial methodology. trials unit Validity workshop [DOI] 10.1186/s12874-022-01609-6 PMC 바로가기 [Article Type] Review