PASC – Page 7 – Communicable Diseases Research

Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection

SARS-CoV-2 감염의 급성 후유증에서 폐 기능 장애의 면역 섬유증 드라이버

Clinical Medicine

Published on 2021-07-222022-09-12
Journal: JCI Insight
[Category] SARS, 진단,

[키워드] acute COVID-19 acute COVID-19 illness affected alveolar American Heart Association Analysis Award Benign carbon monoxide Clinical data correlated cough COVID-19 COVID-19 illness COVID-19 severity declined diffusing diffusing capacity discriminant analysis donation driver Duke Dyspnea element enrolled expiratory Factor Factors fibrosis forced expiratory volume forced vital capacity foundation funding FVC Growth factors heart hematology HGF Hospitalized ICU impaired lung function impairment individual Inflammatory intensive care intensive care unit interquartile range Lcn2 lipocalin-2 lung median Mild multiplex neutrophil neutrophil activation Neutrophils Partial participant PASC performed plasma biomarker plasma sample plasma samples profile prognostic Program prospective cohort study Pulmonary function Pulmonary function tests Pulmonology recovering from COVID-19 respiratory symptom respiratory symptoms SARS-COV-2 infection severity Signaling significantly higher Subjective Symptom Symptoms targets therapeutic university validation cohort vital capacity Volume with COVID-19 Yale University
[DOI] 10.1172/jci.insight.148476 PMC 바로가기 [Article Type] Clinical Medicine

SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney

시리아 햄스터 모델의 SARS-COV-2 감염은 심장과 신장을 포함한 호흡기 및 비-자극 조직 모두에서 I 형 INTERFERON DYSREGUM뿐만 아니라 염증을 유발합니다.

Research Article

Published on 2021-07-152022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, COVID-19, SARS,

[키워드] (coronavirus disease 2019 acute respiratory syndrome Affect affecting antiviral cytokine antiviral cytokines antiviral response captures cardiovascular system cause caused clinical symptom coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines damage disease dysregulation evaluate Evidence evidence of examination extrapulmonary tissue hamsters heart host response host responses IL-1beta IL-6 immune host response immune responses indicated Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibited interferon interferons investigated kidney kidneys liver microthrombi multiorgan disease myocarditis neurological system non-respiratory tissue occur organ system organ systems PASC people with COVID-19 prolonged disease regulated required respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity significant increases in Symptom Therapeutics TNF tubular inflammation type I interferon type I interferons type II interferon type II interferons upregulation Urinary tract Viral viral infection with infection
[DOI] 10.1371/journal.ppat.1009705 PMC 바로가기 [Article Type] Research Article

A longitudinal SARS-CoV-2 biorepository for COVID-19 survivors with and without post-acute sequelae

급성 후유증이 있거나없는 코비드 -19 생존자를위한 종 방향 SARS-COV-2 Biorepository

Research Article

Published on 2021-07-132022-09-01
Journal: BMC Infectious Diseases
[Category] SARS, 진단,

[키워드] acute COVID-19 acute infection All participants Biobank biobanking Biorepository clinical trial clinically cognitive collected Community coronavirus COVID-19 death demographic data dependent on Diagnosis disease dysfunction enrolled exercise intolerance fatigue Follow-up globe hospital Hospitalization Hospitalized identify Infection initial knowledge Long-hauler longitudinal Loss of Smell loss of taste nasopharyngeal participant PASC pathophysiology Patient PCR phenotype physical positive post infection Post-acute sequelae of COVID-19 (PASC) provide questionnaire recruited reduce Registered reported required Research researcher response responses Result risk Saliva SARS-CoV-2 SARS-COV-2 infection significantly more specimens Spectrum Stool Surveillance survivor Symptom Symptoms symptoms of COVID-19 targeted intervention targeted interventions Taste Treatment vaccination valuable resource Viral viral pathology
[DOI] 10.1186/s12879-021-06359-2 PMC 바로가기 [Article Type] Research Article

Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning

기계 학습을 사용하여 디코딩된 COVID-19 심각도 및 만성의 면역 기반 예측

Immunology

Published on 2021-06-282022-09-12
Journal: Frontiers in Immunology
[Category] MERS, SARS, 진단,

[키워드] activated T cells Activation activities analyzed approach B-cell bioinformatics CCL3 CCL4 CCR5 CD14+ CD16+ CD4 CD8 characterized chemokines Classifier continuum COVID COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient cytokine Cytokines dataset defined disease dysregulated effective effector T cell elevated excessive inflammation expressing generate GM-CSF healthy control healthy controls identify IFN-γ IL-10 IL-2 IL-4 IL-6 IL-8 immune response implicated individual individuals induce investigated Ligand machine learning Model mononuclear cell PASC Patient PBMCs Peripheral blood plasma positive predict prediction pro-inflammatory random recruitment second significantly significantly lower subset Symptoms T cell activation T-cell T-regulatory cell treatment strategy VEGF virus while
[DOI] 10.3389/fimmu.2021.700782 PMC 바로가기 [Article Type] Immunology

Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms

Microbiology

Published on 2021-06-232022-10-31
Journal: Frontiers in Microbiology
[Category] COVID-19,

[키워드] acute COVID-19 acute respiratory syndrome acute SARS-CoV-2 infection Autoimmunity Biological Brainstem Care caused condition consequence Consequences coronavirus coronavirus disease Course COVID COVID-19 Diagnosis driving Factor fatigue globe Health herpesvirus Host host proteins immune cells immune dysregulation include Infection Injury Interaction Long Long COVID mechanism Microbiome molecular multiple organs pandemic PASC pathogen Patient persistent Potential required reservoir RNA virus SARS-CoV-2 Signaling subset Symptom Symptoms syndrome therapeutic approach tissues Vagus virus
[DOI] 10.3389/fmicb.2021.698169 PMC 바로가기 [Article Type] Microbiology

Insights into SARS-CoV-2 Persistence and Its Relevance

Review

Published on 2021-05-292022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

Enhanced External Counterpulsation as a Novel Treatment for Post-acute COVID-19 Sequelae

Internal Medicine

Published on 2021-04-072022-10-31
Journal: Cureus
[Category] COVID-19,