NETosis: Molecular Mechanisms, Role in Physiology and PathologyNETosis: 분자 기전, 생리학 및 병리학에서의 역할Review Published on 2020-10-012022-09-12 Journal: Biochemistry. Biokhimiia [Category] MERS, SARS, 진단, [키워드] antibody chromatin chromatin decondensation component Concentration COVID-19 Cytokines cytoplasm cytosol disease Granule histone Immune complexes include increase in induction mechanism Modification NADPH oxidase NETosis NETs Neutrophil extracellular trap nuclear envelope Pathogenesis Pathogens physiological Physiology plasma membrane Protein reactive oxygen specy role ROS [DOI] 10.1134/S0006297920100065 PMC 바로가기 [Article Type] Review
ACE2 in the Era of SARS-CoV-2: Controversies and Novel PerspectivesMolecular Biosciences Published on 2020-09-302022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] “cytokine storm” accumulates ACE ACE inhibitor ACE2 ACE2 expression ACE2 protein ACE2 receptor acute respiratory syndrome Administered Alter Angiotensin receptor blockers angiotensin-converting enzyme 2 antibodies appear binding biochemical Biochemistry cardioprotection cardiovascular system cellular clinical investigation competitive binding COVID-19 COVID-19 disease COVID-19 pandemic Cytokine storm determinant downregulation drugs Effect effort engage enzyme Epigenetic event Evidence exogenously forms glycosylation Host host cell membrane hypertension induce Infection initial Interaction intestine kidney knowledge limit Lung inflammation mammalian mechanism Medical conditions MicroRNAs modulation Neutralizing novel observation pathogenicity pathophysiological pathophysiology peptides Phosphorylation plasma membrane Protein reduce reduced regulated Replication respiratory tract responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe COVID-19 small molecule Spike protein Strategy subunits: S1 tissues transcriptional viral envelope viral genome virus virus entry [DOI] 10.3389/fmolb.2020.588618 PMC 바로가기 [Article Type] Molecular Biosciences
Caveolae and Lipid Rafts in Endothelium: Valuable Organelles for Multiple FunctionsReview Published on 2020-08-212022-10-28 Journal: Biomolecules [Category] Coronavirus, [키워드] adipocytes Angiogenesis biogenesis caused caveolae caveolin cavin Cell cell type cholesterol COVID-19 endocytosis Endothelial cell endothelial cells Extracellular fatty acids function functions heterogeneous human disease increase in invagination involved Lipid lipid composition Lipid rafts living cells marker mechanism membrane metabolism Microscope Migration molecular Multiple organelle plasma membrane platform proliferation Protein raft saturated sphingomyelin unique Vascular virus entry [DOI] 10.3390/biom10091218 PMC 바로가기 [Article Type] Review
The Strengths of Scanning Electron Microscopy in Deciphering SARS-CoV-2 Infectious CycleMicrobiology Published on 2020-08-192022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Cell cell lysis cells classical comparable Complete complex contributed coronavirus cycle Diagnosis electron electron microscopy electronic microscopy expelled helping infectious cycle membrane fusion Microscopy New Particle Patient plasma membrane Post-infection powerful tool public health Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 particle scanning scanning electron microscopy SEM significantly strength TEM Transmission Vero E6 cell VERO E6 cells viral infections virus [DOI] 10.3389/fmicb.2020.02014 PMC 바로가기 [Article Type] Microbiology
Coronavirus Interplay With Lipid Rafts and Autophagy Unveils Promising Therapeutic TargetsMicrobiology Published on 2020-08-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] agent anti-viral role approach autophagic autophagy cell entry Cluster Contact coronavirus Coronavirus infection Coronavirus infections Coronaviruses COVID-19 Degradation disrupt drugs Health highly pathogenic host cell Host immune response hosts induce infect Infection inhibit inhibitor investigated involved Lipid Lipid rafts Mild occur pandemic pathogen plasma membrane positive-sense potential therapeutic target raft recent receptor regions Replication reported representing researcher respiratory diseases responsible RNA virus SARS-CoV-2 shown single-stranded target this new coronavirus treat Treatment Vaccine variant viral infections viral products virus viruses [DOI] 10.3389/fmicb.2020.01821 PMC 바로가기 [Article Type] Microbiology
Cholesterol in Relation to COVID-19: Should We Care about It?Editorial Published on 2020-06-182022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 activities acute respiratory syndrome addition angiotensin-converting enzyme 2 Anti-inflammatory Antithrombotic antiviral activity appear Atherosclerosis Blood cardiovascular complication cardiovascular disease caused cholesterol Clinical course complications of COVID-19 contributing to coronavirus Coronavirus infection COVID-19 critical appraisal current CVD Effects evidence of Hepatitis host cell hypertension immunomodulatory Infection influenza infection inhibitors intubation lipid-lowering therapy Lower Mortality Patient pharmacological interventions plasma membrane pleiotropic effect receptor reduce reducing relation reported risk S-protein SARS-CoV-2 SARS-CoV-2 main protease severity shown statin statins therapy viral clearance viral entry viral infection viral infectivity virus [DOI] 10.3390/jcm9061909 PMC 바로가기 [Article Type] Editorial
The Role of Extracellular Vesicles as Allies of HIV, HCV and SARS VirusesReview Published on 2020-05-222022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] Ally biogenesis caused Cell Coronaviruses EVs Exosomes Extracellular Extracellular vesicles functional HCV HIV in viral Infection Intercellular communication knowledge nucleic acid Other pathogen Pathogens pathological conditions physiological plasma membrane Protein released respiratory role SARS virus SARS viruses therapeutic strategy Vesicle viral infection virus viruses [DOI] 10.3390/v12050571 PMC 바로가기 [Article Type] Review
Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusionArticle Published on 2020-03-302022-10-04 Journal: Cell Research [Category] MERS, SARS, 치료제, [키워드] amino acid residue caused circulating coronavirus coronavirus disease COVID-19 defined develop domain effective electron microscopy examined global public health HCoV-OC43 HR1 domain human coronavirus IC50 Infection inhibit inhibited inhibition inhibitor Interaction membrane fusion MERS-CoV mice molecular mechanism mutated outbreak peptide plasma membrane pseudovirus pseudovirus infection Replication S protein S2 subunit SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike SARSr-CoVs Spike protein tested the SARS-CoV-2 Treatment viral infection Wuhan, China X-ray [DOI] 10.1038/s41422-020-0305-x PMC 바로가기 [Article Type] Article
PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complexPRM1 및 KAR5는 세포-세포 융합 및 핵종에서 기능하여 Cryptococcus 병원성 종 복합체에서 뚜렷한 양성 및 단성 주기를 유도합니다Research Article Published on 2017-11-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence adaptation bisexual reproduction Cell Cell fusion cell-cell fusion cellular processe characterization characterized complex conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans de novo demonstrated diploid eukaryotic eukaryotic systems events Evolution forms fungal fungal pathogens fungi fusion protein generate Genetic genotypic hyphae hyphal independent individual involved isolate karyogamy mating type mechanism Morphological nuclear nuclear fusion nuclear membrane observation occur offset opposite organism ortholog orthologs pathogen pathogenic Pathogens pathway phenotypic diversity plants plasma membrane PRM1 produced regulate selfing sexual cycles sexual reproduction Sexuality similarities similarity Stage trajectory undergo yeast [DOI] 10.1371/journal.pgen.1007113 PMC 바로가기 [Article Type] Research Article
The Important Role of Lipid Raft-Mediated Attachment in the Infection of Cultured Cells by Coronavirus Infectious Bronchitis Virus Beaudette StrainResearch Article Published on 2017-01-122022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] attachment biochemically Cell cellular entry cellular membrane centrifugation cholesterol coronavirus demonstrated depleting early stage expression Factor genome replication host cell IBV IBV infection IBV-infected cell indicated Infectious Bronchitis Virus Infectivity Lipid marker Mevastatin non-structural proteins plasma membrane reduced required role significantly stages strain structural protein structural proteins suppressed Treatment Vero Cell virion viruses [DOI] 10.1371/journal.pone.0170123 PMC 바로가기 [Article Type] Research Article