Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence: Navigating the absence of a gold standard심한 급성 호흡기 증후군 코로나 바이러스 2 (SARS-COV-2) 혈청 유병률 : 금 표준의 부재를 탐색Research Article Published on 2021-09-232022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Abbott absence acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 assays Bayesian Blood donors can be used Canada Characteristics class conducted coronavirus COVID-19 pandemic credible interval CrI cross-sectional cross-sectional study diagnostic First wave gold gold standard healthy blood donor highest house IgG IgG antibody IgG ELISA immunoassay Latent Model nucleocapsid pandemic plasma sample plasma samples positive predicted Receptor binding domain reference standard Reference standards respiratory Result SARS-CoV-2 sensitivity Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike spike glycoprotein unique waned was tested while [DOI] 10.1371/journal.pone.0257743 PMC 바로가기 [Article Type] Research Article
Kinetics of SARS-CoV-2 Specific and Neutralizing Antibodies over Seven Months after Symptom Onset in COVID-19 PatientsResearch Article Published on 2021-09-222022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval acute phase acute respiratory syndrome administration age anti-SARS-CoV-2 antibody antibodies antibody Characteristics China collected conducted convalescent COVID-19 patient Convalescent patients coronavirus coronavirus disease COVID-19 COVID-19 convalescent patient COVID-19 patient Dilution discharge discharged disease severity enrolled Evidence Factor Follow-up follow-up period follow-up time geometric mean titer GMT hospital IgG IgM IgM/IgG immune response inhibitory interquartile range Jiangsu Kinetics male median Month natural infection Neutralizing activity neutralizing antibody Onset participant Patient patients persistence plasma sample produced SARS-CoV-2 serological seropositive serum sample severity significantly higher significantly lower Specific Standard deviation symptom onset tested Vaccine virus dynamics with COVID-19 [DOI] 10.1128/Spectrum.00590-21 PMC 바로가기 [Article Type] Research Article
Pre-evaluation assessment of serological-based COVID-19 point-of-care lateral flow assays in KenyaOriginal Research Published on 2021-09-172022-10-28 Journal: African Journal of Laboratory Medicine [Category] COVID-19, [키워드] Asymptomatic authorisation board China collected coronavirus disease COVID-19 COVID-19 testing detect Emergency use IgG IgM IgM and IgG Immunity intensity Kenya lateral flow management national regulatory authority nine objective outcome Pharmacy plasma sample point-of-care point-of-care test Poison polymerase chain ranged Result reverse transcription SARS-CoV-2 sensitivity serological specificity submitted Support turn were used [DOI] 10.4102/ajlm.v10i1.1317 PMC 바로가기 [Article Type] Original Research
Competitive ELISA for a serologic test to detect dengue serotype-specific anti-NS1 IgGs using high-affinity UB-DNA aptamersArticle Published on 2021-09-092022-10-04 Journal: Scientific Reports [Category] 진단, [키워드] Antigen antigen-detection Biological techniques blood sample Care Combination cross-reactivity detect develop Diagnostic method diagnostics Diseases DNA ELISA enzyme-linked immunosorbent facilitate identify IgG Infection inhibited Patient plasma sample positive Protein recognize reflected sandwich ELISA serologic test serotype serotype-specific serotypes Specificities unique Vaccine development viral infection Zika [DOI] 10.1038/s41598-021-97339-8 PMC 바로가기 [Article Type] Article
Identification of Immune Activation Markers in the Early Onset of COVID-19 InfectionCOVID-19 감염의 초기 발병에서 면역 활성화 마커의 식별Cellular and Infection Microbiology Published on 2021-09-032022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 바이오마커, [키워드] age analyzed associated symptoms CoV COVID-19 COVID-19 associated symptoms COVID-19 infection cross-sectional cytokine cytokine profile Cytokines determine disease displaying early diagnosis early stage early stages elevated exploratory healthy control healthy controls HGF identification IL7 immune activation Infection inflammatory markers IP-10 marker mDC MIF MIP-1b Negative PCR Onset outpatient clinic Patient patient group PCR test Peripheral blood plasma sample plasma samples positive SARS-CoV-2 SARS-COV-2 infection screened serum sample serum samples single center Symptom symptoms of COVID-19 target tested Treatment university upregulation VEGF Vienna [DOI] 10.3389/fcimb.2021.651484 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Enhancing the Stability of COVID-19 Serological Assay through Metal-Organic Framework Encapsulation금속-유기 프레임워크 캡슐화를 통한 COVID-19 혈청학적 분석의 안정성 향상Article Published on 2021-09-012022-09-11 Journal: Advanced Healthcare Materials [Category] SARS, 진단, 치료기술, [키워드] alleviate among others antibody Antigen antigens approach biospecimens Clinical data complementary condition conformational conformational epitopes COVID-19 COVID-19 patient COVID-19 patients Critical demonstrated diagnostic reagent diagnostic reagents Disease surveillance effective electricity elements elevated temperature encapsulation Enhancing enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes framework growth handling IMPROVE inaccessible metal-organic frameworks plasma sample plasma samples preservation quantification refrigeration resource-limited settings. SARS-CoV-2 SARS-CoV-2 antigens serologic assays stability storage conditions Surveillance temperature the disease [DOI] 10.1002/adhm.202100410 PMC 바로가기 [Article Type] Article
Infant Exposure to Dolutegravir Through Placental and Breast Milk Transfer: A Population Pharmacokinetic Analysis of DolPHIN-1태반 및 모유 전달을 통한 Dolutegravir에 유아 노출 : Dolphin-1의 인구 약동학 분석Online Only Articles Published on 2021-09-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 1:1 Breast breast milk breastmilk contributed CORD covariate covariates Coverage described diagnosed dolutegravir efavirenz Effect elimination rate evaluate exposure to fetal gestation HIV Human immunodeficiency virus immunodeficiency virus Infant infant pharmacokinetics inhibitory concentration investigated Maternal maternal plasma median median time milk mixed-effects modeling participant pharmacokinetic plasma plasma sample Population Population pharmacokinetics predicted Pregnancy presenting Prevent profiles Prophylactic Prophylaxis provided Randomized Rapid reduction in Result South Africa switch therapy threshold Transmission treatment initiation Uganda umbilical Umbilical cord waned was used women [DOI] 10.1093/cid/ciaa1861 PMC 바로가기 [Article Type] Online Only Articles
Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2 in humans and mice인간 및 마우스에서 SARS-CoV-2의 N-말단 도메인에 대한 동종 및 이종 혈청학적 반응Article Published on 2021-09-012022-09-12 Journal: European Journal of Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody Antigen antigenicity caused characterized coronavirus coronavirus disease COVID-19 COVID-19 patients cross-reactive elicited expressed Heterologous Human immunogen infected case Infection less mice MOST N-terminal N-terminal domain neutralizing antibody NTD offer pandemic plasma sample Protein public health RBD Receptor binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 RBD serological response serology serology testing the antibody response the spike protein threat Vaccine development while [DOI] 10.1002/eji.202149234 PMC 바로가기 [Article Type] Article
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection급성 SARS-CoV-2 감염 시 뚜렷한 전신 및 점막 면역 반응Comparative Study Published on 2021-09-012022-09-12 Journal: Nature Immunology [Category] MERS, SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection Adaptive immunity Analysis antibodies Bacteria bacterial communities Bacterial community clinical outcomes clinically Cohort coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cytokine Cytokines Defense determine elevated highlight Humoral response immune response immune responses Immunity implicated Infection Inflammation Inflammatory cytokines interferon Local microbial Microbiome mucosal mucosal immune Mucosal immunology mucosal surfaces nasopharyngeal Nasopharyngeal swab nasopharyngeal viral load Neutralizing antibodies Paired analysis Pathogenic microorganisms Pathologies pathology patients with COVID-19 performed plasma sample plasma samples Potential PROTECT Protective respiratory infections respiratory tract response responses SARS-CoV-2 SARS-CoV-2 spike-specific SARS-CoV-2-infected patient SARS-CoV-2-infected patients secondary respiratory infections severe acute respiratory syndrome Coronavirus severe COVID-19 specific antibodies systemic immune response systemic inflammatory tissue viral infection Viral load [DOI] 10.1038/s41590-021-01028-7 PMC 바로가기 [Article Type] Comparative Study
Stability of SARS-CoV-2 IgG in multiple laboratory conditions and blood sample types여러 실험실 조건 및 혈액 샘플 유형에서 SARS-CoV-2 IgG의 안정성Article Published on 2021-09-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 진단, 치료기술, 치료법, [키워드] antibody Antibody detection Architect assays Beijing blood sample cassettes collected condition conditions COVID-19 demonstrated detect Elecsy ELISA ELISAs evaluated Freeze-thaw cycle Genscript heparin IgG IgG response IgM IgM antibodies IgM antibody Immunoglobulin immunoglobulins individuals Laboratory less lithium Lithium heparin manual material neutralization Neutralization assay nucleocapsid plasma plasma sample plasma samples positive Rapid test rapid test cassette Roche Sample SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SD Biosensor seropositive individual seropositive individuals serum serum/plasma specimen stability storage Test [DOI] 10.1016/j.jcv.2021.104933 PMC 바로가기 [Article Type] Article