Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease InhibitorsArticle Published on 2021-08-122022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] activities affecting antiviral activity Antiviral effect binding binding affinity blocked catalytic cellular COVID-19 COVID-19 outbreak derivative dimeric Diseases drug indicated inhibitors inhibitory inhibitory activity lysine M pro mechanism of action non-toxic Papain-like protease peptide peptide-based peptides potent protease public health system reported SARS-CoV-2 SARS-COV-2 infection Spread synthetic peptide treat viral infections were assessed [DOI] 10.3390/molecules26164896 PMC 바로가기 [Article Type] Article
A Single-Cycle Influenza A Virus-Based SARS-CoV-2 Vaccine Elicits Potent Immune Responses in a Mouse ModelArticle Published on 2021-08-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 5′ UTR Antigen antigenic C-terminus Cell Cell-mediated immunity chimeric cytoplasmic demonstrated domain elicited exhibited expressed expressing Frame gene encoding hosts humoral immune response immunized increasingly infected cell Influenza Influenza virus inoculated MDCK cell Model mouse mucosal Neutralizing activity ORF passages peptide-based platform potent prime-boost regimen producing Protein Pseudotyped virus RBD response robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine sera Seven single-cycle influenza virus-based vaccine spike RBD spike-pseudotyped virus the RBD the SARS-CoV-2 the vaccine Vaccine Vaccine development variants virus [DOI] 10.3390/vaccines9080850 PMC 바로가기 [Article Type] Article
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopesArticle Published on 2021-08-032022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, [키워드] ACE2-binding site acute respiratory syndrome Analysis antibodies Antiviral bind binding binding epitope circulating variant circulating variants class comparison conserved coronavirus COVID-19 therapeutics cryo-EM structures Cryoelectron microscopy determine disrupt effective eight epitope host receptor inaccessible indicate mechanisms Microbiology Microscopy nanobody neutralization neutralize Neutralizing Neutralizing activity neutralizing antibody neutralizing epitope potent provided RBD Receptor binding domain recognize reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 spike Spike protein STABLE structural biology Structure target the SARS-CoV-2 unique Vaccine variant variants of concern variety virus VoC VOCs [DOI] 10.1038/s41467-021-24963-3 PMC 바로가기 [Article Type] Article
Combination Treatment With Remdesivir and Ivermectin Exerts Highly Synergistic and Potent Antiviral Activity Against Murine Coronavirus Infection렘데시비르와 이버멕틴의 병용 치료는 쥐 코로나바이러스 감염에 대해 높은 시너지 효과와 강력한 항바이러스 활성을 나타냅니다.Cellular and Infection Microbiology Published on 2021-07-302022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] activity Against antiviral drug antiviral therapy Betacoronavirus Betacoronavirus genus both viruses Cell Chloroquine clinical clinical trial clinical trials Combination combination therapy combination treatment coronavirus COVID-19 COVID-19 pandemic cytokine level develop doxycycline drug drug therapy effective Efficacy evaluated exhibited Hepatitis highest IC50 IL-6 in vitro model in vivo experiment indicated infect Infection inhibitory investigated Ivermectin ivermectin treatment leukemia Live virus lowest Macrophage macrophages mechanism MHV mice monotherapy murine hepatitis virus potent RAW264.7 macrophage cells reduction Remdesivir Replication Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections selectivity index sequence identity significant reductions synergism synergistic tested the Betacoronavirus the disease therapy TNF-α Treatment Trial urgency viability Viral Viral RNA virus viruses [DOI] 10.3389/fcimb.2021.700502 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice강력한 백혈구 변환 차단제 : GT-73은 마우스에서 LPS- 유도 된 ARD에 대한 보호 효과를 나타냈다.Article Published on 2021-07-292022-08-31 Journal: Molecules [Category] SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome addition Adhesion Molecule affecting applied ARDS BALF bind biochemical blocked blocker Blood blood cell Bronchoalveolar lavage fluid caused cell adhesion molecule covalent inhibitor COVID-19 patient COVID-19 patients Critical Cytokine storm derivatives drug candidate Effect Endothelial cell evaluate finding histological IL-1β IL-6 infiltrating Inflammation investigated leukocyte leukocyte transmigration leukocytes lung Lungs MCP-1 Migration molecule Mortality mouse model PECAM-1 peripheral tissues Platelet potent prodrug rationale reduced respiratory distress Respiratory distress syndrome responsible Showed significantly syndrome TERT transendothelial migration transmigration Treatment unique was tested was used White blood cell [DOI] 10.3390/molecules26154583 PMC 바로가기 [Article Type] Article
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2Article Published on 2021-07-092022-10-04 Journal: Nature Communications [Category] SARS, 변종, [키워드] ACE2 Analysis angiotensin-converting enzyme-2 antibodies antibody Antibody Response antigenic variation approach B.1.351 variant binding biologic COVID-19 disease COVID-19 patients Critical crystal Efficacy eight escape mutation feature Genetic highlight identify immunology in vitro in vivo Infection Intervention K417N Mutagenesis mutant Mutation NAb natural mutation Neutralizing activity neutralizing antibody overcome overlap Patient potent Protective Protein RBD receptor residue reveal SARS-CoV-2 SARS-COV-2 infection South Africa structural biology the Spike Vaccine virus [DOI] 10.1038/s41467-021-24514-w PMC 바로가기 [Article Type] Article
Potent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccinationResearch Article Published on 2021-07-082022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] Analysis B.1.1.7 B.1.351 B.1.351 variants B.1.429 B.1.526 boost COVID-19 D614G diagnostic DNA DNA vaccine domain effective elicited epitope Epitopes heterologous prime-boost immunization host immunity induce Measures monoclonal antibody neutralization neutralization potency neutralize Neutralizing overlapping P.1 point-of-care potent priming Protein pseudovirus rabbit mAb RBD RBD protein recognize S1 protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 WT Sequence analysis Spike protein tested the SARS-CoV-2 vaccination Vaccine variant Variant of concerns variants virus wild type [DOI] 10.1080/22221751.2021.1942227 PMC 바로가기 [Article Type] Research Article
High-Throughput Screening and Quantum Mechanics for Identifying Potent Inhibitors Against Mac1 Domain of SARS-CoV-2 Nsp3SARS-CoV-2 Nsp3의 Mac1 도메인에 대한 강력한 억제제를 식별하기 위한 고성능 스크리닝 및 양자 역학Article Published on 2021-07-012022-09-11 Journal: IEEE/ACM transactions on computational biology and [Category] SARS, 치료제, [키워드] acceptor ADP-ribose ADP-ribosylation Against Antiviral antiviral activity binding binding pocket compounds conserved coronavirus CoV database docking domain Donor drug target electron donor ENCODE enzymatic activity enzyme host response identifying inhibitor inhibitors Interaction Mac1 Mechanics molecular dynamics mono nonstructural protein 3 Nsp3 other coronaviruses pathogenicity phosphate potent protein 3 provide quantum regions Regulatory residue ribose SARS-CoV-2 Screening substrate Tight binding unique viral infections virulence virulence factor Zinc [DOI] 10.1109/TCBB.2020.3037136 PMC 바로가기 [Article Type] Article
Plant-Based Phytochemical Screening by Targeting Main Protease of SARS-CoV-2 to Design Effective Potent InhibitorsArticle Published on 2021-06-262022-10-28 Journal: Biology [Category] COVID-19, [키워드] active site acute respiratory syndrome ADMET adverse effects Antiviral antiviral drug Asian binding affinity biological activity carcinogenicity caused Characteristics complex complexes compounds coronavirus coronavirus disease COVID-19 Cys145 deviation disease docked drug drug candidate dynamics simulation effective Efficacy exhibited expressed fluctuation gallate high mortality rate His41 in viral inhibitor Laboratory M pro molecular docking Molecular dynamics simulation pathway pharmacological phytochemical phytochemicals plant plants potent profile protease Protein radius of gyration Replication reported retrieved SARS-CoV-2 Screening simple Spread supported targeting thermal stability these compound Toxicity Transcription treat Treatment Vaccine viral infection was used were assessed worldwide pandemic [DOI] 10.3390/biology10070589 PMC 바로가기 [Article Type] Article
Potent neutralizing RBD‐specific antibody cocktail against SARS‐CoV‐2 and its mutantOriginal Article Published on 2021-06-242022-10-30 Journal: MedComm [Category] COVID-19, [키워드] ACE2 binding acute respiratory syndrome antibody antibody cocktail can be used caused cocktail Combination contagious coronavirus Cyro‐EM demonstrated described dissemination effective epitope epitopes group exhibited global public health group high affinity hotspot Intervention isolates mAb mAb cocktail mAbs mice monoclonal antibody mutant mutants neutralization Neutralizing neutralizing antibody pandemic potent Prevent Prophylactic Protein pseudotype pseudovirus RBD receptor‐binding domain receptor‐binding domain recognize recognizing reveal SARS‐CoV‐2 SARS‐CoV‐2 selected the RBD the spike protein therapeutic Transmission treat V367F vaccination Vaccine variant virus wildtype [DOI] 10.1002/mco2.79 PMC 바로가기 [Article Type] Original Article