Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaquesAd26.COV2.S는 햄스터와 붉은털 원숭이에서 SARS-CoV-2 유도 염증 및 혈전증 경로의 상향 조절을 방지합니다Article Published on 2022-04-082022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Ad26 Ad26.COV2.S Adaptive immune response Adenovirus animal models B cell B.1.351 binding comparable complement COVID-19 COVID-19 pathogenesis expressing feature golden hamsters hamster hamsters human disease immune responses immunization induce Inflammation Inflammatory molecular mechanism molecular mechanisms mRNA expression profile mRNA expression profiles myeloid Neutralizing antibody response neutralizing antibody responses Pathogenesis pathway Pathways Prevent prevented Protective proteomics recent rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 WA1/2020 serotype severe COVID-19 severe disease shown Spike protein stimulate Syrian golden hamster Syrian Golden hamsters These data thrombosis transcriptional type I interferon uninfected upregulation vaccination Vaccine Vaccines weight loss with COVID-19 [DOI] 10.1371/journal.ppat.1009990 PMC 바로가기 [Article Type] Article
Two Green Micellar HPLC and Mathematically Assisted UV Spectroscopic Methods for the Simultaneous Determination of Molnupiravir and Favipiravir as a Novel Combined COVID-19 Antiviral Regimen새로운 결합된 COVID-19 항바이러스 요법으로서 Molnupiravir와 Favipiravir의 동시 측정을 위한 2개의 Green Micellar HPLC 및 수학 보조 UV 분광법Article Published on 2022-04-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] adjusted Analytical chemistry Antiviral applied Brij-35 classical Combination Combined composed conditions construction COVID-19 COVID-19 pandemic COVID-19 regimen Determination drug Efficacy extraction Favipiravir FIVE flow rate Genetic Genetic algorithm green harmony HPLC increase initiated isocratic less Liquid chromatography lung Lungs medication micellar liquid chromatography molnupiravir monobasic potassium phosphate novel overlapping partial least square partial least squares PCR phosphate plateau Potassium potassium phosphate predicted prevented Principal component regimen released SARS-CoV-2 virus SDS similarity Simultaneous Spread Tablet the SARS-CoV-2 virus trials UV–VIS Spectrophotometry Viral transmission [DOI] 10.3390/molecules27072330 PMC 바로가기 [Article Type] Article
Pharmacological treatment of COVID-19: an opinion paperCOVID-19의 약리학적 치료: 의견서Review Published on 2022-04-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] COVID19(2023년), SARS, 치료제, [키워드] adalimumab Anakinra approach AZD7442 Azithromycin Banlanivimab Baricitinib BRII-196 BRII-198 canakinumab Casirivimab Certolizumab Ciganilmab Colchicine college Committee convalescent convalescent plasma COVID-19 Critical Dexamethasone drug drugs effective Efficacy English Etanercept etesevimab Evusheld Favipiravir fluvoxamine Golimumab help Hydroxychloroquine Imdevinab immune response Immunotherapy indication infliximab itolizumab Ivermectin Lemilumab Lopinavir Lopinavir/ritonavir Medicines metformin molnupiravir offer Pandemia pandemic Paxlovid PF-07321332 physician precocity prevented Ravulizumab Remdesivir Ritonavir ruxolitinib sarilumab SARS-CoV-2 Scientific Committee Sotrovimab Spanish the vaccine therapeutic Tixagevimab Tocilizumab Tofacitinib Treatment Vaccine virus Vitamin Vitamin D [DOI] 10.37201/req/158.2021 PMC 바로가기 [Article Type] Review
Risk for Reinfection After SARS-CoV-2: A Living, Rapid Review for American College of Physicians Practice Points on the Role of the Antibody Response in Conferring Immunity Following SARS-CoV-2 InfectionSARS-CoV-2 후 재감염 위험: SARS-CoV-2 감염 후 면역을 부여하는 데 있어 항체 반응의 역할에 대한 미국 의과대학 실습 요점을 위한 살아있는 신속한 검토Review Published on 2022-04-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Alpha variant Asymptomatic Care Clinical practice college database Delta diagnose eligible Evidence General population Health care Health care worker health care workers Health Organization Immunity Immunocompromised index case individual individuals Infection infection risk infection with SARS-CoV-2 investigator Longitudinal studies longitudinal study Meta-analysis omicron OVID Patient physician Point Practice prevented PROSPERO protection public health Quality Racial ranged Rapid reduced risk Reinfection remained response Result review risk risk difference role SARS-CoV-2 SARS-COV-2 infection strength subgroups symptomatic symptomatic infection symptomatic infections uninfected variant variants wild-type World Health Organization [DOI] 10.7326/M21-4245 PMC 바로가기 [Article Type] Review
Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: an exploratory, randomised, placebo-controlled trialClinical Trial Published on 2022-04-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, 치료법, [키워드] 1:1 A significant reduction all-cause mortality assigned Baricitinib baseline Blood clots Brazil cardiovascular event Care Cohort Combination company conducted Corticosteroids Critically ill death died double-blind duration of hospitalisation Efficacy efficacy analysis Efficacy and safety Endpoint enrolled evaluate event exploratory extracorporeal membrane oxygenation hazard ratio hospital hospitalised hospitalised patient infections inhibitor intention-to-treat population Invasive mechanical ventilation investigator Janus kinase laboratory-confirmed SARS-CoV-2 infection less Lilly membrane Mortality not differ participant Participants Patient Phase 3 phase 3 trial Placebo placebo-controlled trial placebo-treated participant prevented randomised Randomly receiving reduced reduction Registered risk reduction safety analysis safety population SARS-COV-2 infection selective severely ill patient shown significantly significantly shorter Standard Standard of care Study design study group study population systemic corticosteroid the placebo group Time to recovery Treatment treatment group treatment groups Trial USA ventilator-free day Ventilator-free days was done with COVID-19 [DOI] 10.1016/S2213-2600(22)00006-6 PMC 바로가기 [Article Type] Clinical Trial
Study of immunogenicity, safety and efficacy of covishield vaccine among health care workers in a tertiary cardiac care centre3차 심장치료센터 의료진을 대상으로 한 covishield 백신의 면역원성, 안전성 및 유효성 연구Article Published on 2022-04-012022-09-12 Journal: Indian journal of medical microbiology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Adverse Adverse events following immunisation (AEFI) average Breakthrough infection Care conducted coronavirus Covishield dose doses duration of symptom Efficacy event Fever HCWs Health care Health care worker Health care workers (HCWs) IgG antibody increase in interval local pain median value Mild pandemic participant post vaccination prevented reduced Research safety profile SARS-CoV-2 second dose Seropositivity severity Severity of infection Study participants Symptom uninfected vaccination Vaccine were assessed [DOI] 10.1016/j.ijmmb.2022.03.003 PMC 바로가기 [Article Type] Article
BNT162b2 Protection against the Omicron Variant in Children and AdolescentsBNT162b2 아동 및 청소년의 오미크론 변이체에 대한 보호Original Article Published on 2022-03-302022-09-25 Journal: The New England Journal of Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Adolescent age B.1.1.529 B.1.617.2 BNT162b2 caused center children circulation Control controls coronavirus coronavirus disease Critical death died dose Effectiveness enrolled hospital Hospitalization immune evasion laboratory-confirmed median interval Messenger RNA of BNT162b2 omicron Patient prevented protection provided reduced Result risk SARS-CoV-2 Support vaccination Vaccine variant [DOI] 10.1056/NEJMoa2202826 PMC 바로가기 [Article Type] Original Article
First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variantsSARS-CoV-2 및 변이체에 대한 강력한 예방 및 치료 효능을 지닌 동급 최초의 삼중특이성 VHH-Fc 기반 항체Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, [키워드] ACE-2 addition antibody Antibody therapy cellular characterized comparable COVID-19 cases COVID-19 pandemic COVID-19 vaccination death Delta demonstrated distribution Drug development Efficacy Efficacy and safety epitope evaluated feature greatly reduce hospitalizations humanized Immunity in vitro in vivo intranasal lead Measures multiple epitope omicron parameter PBS prevented Prophylactic Prophylaxis provided reduced reported safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutants shown tested the vaccine the vaccines therapeutic efficacy Treatment treatment for COVID-19 variant Viral Viral load viral loads while [DOI] 10.1038/s41598-022-07952-4 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humansSARS-CoV-2 단일클론항체 조합인 AZD7442는 인간이 아닌 영장류를 보호하고 인간에서 반감기가 연장됩니다.Article Published on 2022-03-092022-09-11 Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 비임상, 진단, 치료기술, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration angiotensin angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor antibody benefit binding cell entry cilgavimab Combination Concentration convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 death Epitopes extrapolation fold functions geometric geometric mean greater half-live healthy Human individual Infection Initially Intramuscular injection lung mAb mAbs monoclonal antibodies monoclonal antibody combination nasal mucosa neutralize Neutralizing titer nonoverlapping epitope nonoverlapping epitopes participant Phase 1 phase 1 study Prevent prevented Prophylactic Protective provided receptor Receptor binding domain reduce remained respiratory risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant serum severe acute respiratory syndrome Coronavirus severe disease Spike protein Spike protein receptor binding domain tested the spike protein therapeutic Tixagevimab treat Treatment Vaccines Viral viral spike protein virus virus clearance [DOI] 10.1126/scitranslmed.abl8124 PMC 바로가기 [Article Type] Article
Dietetic-Led Nutrition Interventions in Patients with COVID-19 during Intensive Care and Ward-Based Rehabilitation: A Single-Center Observational StudyObservational Study Published on 2022-03-032022-10-04 Journal: Nutrients [Category] MERS, SARS, 임상, [키워드] Admission calory clinical collected complex conducted Course COVID-19 COVID-19 patient dietitian/dietician dysfunction hospital Hospital stay ICU ICU admission intensive care Intervention knowledge London lost weight Malnutrition management medical treatment nutrition nutritional need nutritional needs pandemic Patient patients with COVID-19 prevented propofol prospective observational study protocol provided recruited rehabilitation renal function required weight loss with COVID-19 [DOI] 10.3390/nu14051062 PMC 바로가기 [Article Type] Observational Study