NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterraneaNF-YB는 Planarian Schmidtea 지중해에서 정자 줄기 세포 자가 재생 및 증식을 조절합니다Research Article Published on 2016-06-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] balance carrier causative agent Cell cell population cell proliferation cells combating complex component conserved coordination developmental differentiation disease Disruption etiology Factor fecundity Gamete genetic information germ cell germ cells help homolog identification implication Implications infertility inhibited involved lead life maintenance male mechanism morbidity observation open organism Organisms parasite Pathogenesis Planarian proliferation Propagation reproductive required Schistosoma mansoni schistosome Schistosomiasis Sperm SSC STEM stem cell stem cells testes transcription factors Transmission tropical tropical disease Tumor tumorigenesis tumors [DOI] 10.1371/journal.pgen.1006109 PMC 바로가기 [Article Type] Research Article
Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone MachinesHsp40s는 Hsp104 및 Hsp90 단백질 샤페론 기계의 기능을 지정합니다Research Article Published on 2014-10-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activities activity alteration amplification Bacterial C-terminal C-terminal domain Cell cellular chaperone chaperones competing complement complex complexes component conformation cooperation domain explain function functional functions growth help Hsp70 increasingly Interaction less machine maintain microorganism microorganisms overexpressed overexpressing plant plants polymers promote Propagation PROTECT Protein Proteins PSI regulate Regulation Replication respond specific activities Stress Support thermotolerance underlie yeast [DOI] 10.1371/journal.pgen.1004720 PMC 바로가기 [Article Type] Research Article
Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic RegionsPrion 균주의 광범위한 다양성은 차등 샤페론 상호 작용 및 고유한 아밀로이드 생성 영역에 의해 정의됩니다Research Article Published on 2014-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate aggregates aggregation amyloid Analysis canonical chaperone cofactor cofactors complex conformation conformational conformational change consequence Critical determinant disease disease pathology Disease progression Diseases disorders Diversity domain element examined Extensive Factor help Host Hypothesis induce Interaction involved manifestation modulating molecular neurodegenerative pathology phenotypic phenotypic variation prion progression Propagation Protein Proteins provided PSI Region responsible stability strain Strains structures Support These data Transmission unique Variability variant variants Variation variety widespread yeast [DOI] 10.1371/journal.pgen.1004337 PMC 바로가기 [Article Type] Research Article
Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegansCaenorhabditis elegans의 소포 수송에 의한 세포 간 프리온 도메인의 확산Research Article Published on 2013-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate aggregation ALS amyloid Amyotrophic lateral sclerosis animal model appearance asparagine Author autonomous autophagy Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans Cell cellular cellular pathway conformation culture cell cytosolic Degradation developmental delay different disease Diseases domain elegan embryonic Encephalopathy Epigenetic Evidence exhibit expressed expressing expression form Glutamine hallmark hallmarks include infect infectious Lateral Sclerosis lobar lysosomal lysosomal vesicle mechanism misfolded protein misfolded proteins mitochondrial multicellular multicellular organism N-terminus naive cells neurodegenerative neurodegenerative disorders NM organism Parkinson's Disease pathology pathway prion Propagation Protein Proteins real time recent Spread spreading thought tissue tissue culture tissues Toxicity trait transgenic mice transmissible spongiform encephalopathies Transmission Transport underlie Vesicle vesicular widespread yeast [DOI] 10.1371/journal.pgen.1003351 PMC 바로가기 [Article Type] Research Article
Human airway epithelial cell culture to identify new respiratory viruses: Coronavirus NL63 as a modelArticle Published on 2008-12-052022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] airway amplification amplify antibody approach approaches Cell culture cell line clinical samples coronavirus CPE, cytopathic effect Culture culture supernatant cultures Cytopathic effect described detect determine different time point epithelial evaluated experiment HAE HAE culture HAE, human airway epithelium HCoV-NL63 HCoV-NL63, human coronavirus NL63 Human identify Infection lack molecular NL63 nucleic acid pathogen Pathogens Propagation reagent reported respiratory pathogen respiratory viral respiratory virus SARS-CoV, severe acute respiratory syndrome coronavirus secretion sequence Sequence analysis TEM TEM, transmission electron microscopy Transcriptome transmission electron microscopy variety virus Whole transcriptome amplification WTA, whole transcriptome amplification [DOI] 10.1016/j.jviromet.2008.10.022 PMC 바로가기 [Article Type] Article