Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicityArticle Published on 2022-06-062023-06-16 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 Plant-produced subunit vaccine protective immunity Receptor binding domain SARS-CoV-2 toxicology [DOI] 10.1016/j.vaccine.2022.05.087 PMC 바로가기 [Article Type] Article
Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination Research Published on 2022-06-012022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] adjusted Blood Ccr6 CD107a CD4+ cell CD4+ T cell CD8+ T cell Cell clinical trials contribute COVID-19 vaccination COVID-19 vaccine Cytokines decrease Donor doses Efficacy elevate expansion expressing expression flow cytometry increase in increases in less linear memory mRNA nasal nasal mucosa Pfizer-BioNTech phenotype protective immunity SARS-CoV-2 SARS-CoV-2 spike peptide second dose shown Stimulation subset Swab T cell upper respiratory tract vaccination Vaccine vaccine dose Vaccines [DOI] 10.1038/s41467-022-30913-4 [Article Type] Research
Reinfection with SARS-CoV-2 in solid-organ transplant recipients: Incidence density and convalescent immunity prior to reinfection고형장기 이식 환자에서 SARS-CoV-2 재감염: 재감염 전 발병률 밀도 및 회복기 면역Article Published on 2022-06-012022-09-12 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Antibody titer CD4 T cells CD4 T-cell CD4+ CD8+ T-cell cellular characterized Cohort convalescent coronavirus COVID-19 Diagnosis evaluated FIVE high risk humoral immune responses hypoxia IgG Immunity incidence incidence density infected with SARS-CoV-2 Infection initial mounted mRNA vaccination Patient patients peptide pools Primary infection protective immunity reactive reactivity Receptor binding domain recipient recipients Reinfection response SARS-CoV-2 solid organ transplant solid-organ transplant SOT the SARS-CoV-2 virus [DOI] 10.1111/tid.13827 PMC 바로가기 [Article Type] Article
The Effect of Age, Gender and Comorbidities Upon SARS-CoV-2 Spike Antibody Induction After Two Doses of Sinopharm Vaccine and the Effect of a Pfizer/BioNtech Booster VaccineSinopharm 백신 2회 접종 후 SARS-CoV-2 스파이크 항체 유도에 대한 연령, 성별 및 동반 질환의 영향과 Pfizer/BioNtech Booster 백신의 효과Article Published on 2022-05-302022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Administered age antibody antibody quantification Bahrain BBIBP-CorV BNT162b2 booster booster dose cause China clinical conditions Cohort Corona coronavirus COVID-19 develop disorders Effect ENhance evaluated immune protection immunoassay individual induction infecting Infection Kingdom levels of antibody Pfizer/BioNTech proportion protective immunity SARS-CoV-2 significant increase significantly Sinopharm spike Spike protein Testing the S protein vaccinated individual vaccination Vaccination strategy Vaccine were given [DOI] 10.3389/fimmu.2022.817597 PMC 바로가기 [Article Type] Article
Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopesArticle Published on 2022-05-252022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] adaptive analyses antibodies antibody antigenic structure binding binding site breadth cause circulating common cold virus conformational change coronavirus domain Endemic epitope Evolution glycoprotein Human human coronavirus OC43 Immunity in-depth analysis Infection infections Neutralizing Neutralizing antibodies neutralizing antibody neutralizing epitope non-neutralizing antibody OC43 persist prefusion S Prevent protective immunity reactive Respiratory disease reveal SARS-CoV-2 subject sustained trimer variants Viral immune evasion while [DOI] 10.1038/s41467-022-30658-0 PMC 바로가기 [Article Type] Article
Characterization of Immune Response Diversity in Rodents Vaccinated with a Vesicular Stomatitis Virus Vectored COVID-19 Vaccine수포성 구내염 바이러스 벡터가 적용된 COVID-19 백신을 접종한 설치류의 면역 반응 다양성 특성화Article Published on 2022-05-242022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome Administered animal model animal models applied BALB/c mice candidate Cellular immune response cellular immunity challenge characterization coronavirus coronavirus disease COVID-19 COVID-19 vaccine Diversity effective Efficacy evaluated hamsters humoral immune response immune response immunization immunization routes intramuscular intranasal Neutralizing neutralizing antibody Protective protective immunity provide public health recombinant COVID-19 vaccine recombinant vesicular stomatitis virus reflect response robust rodent SARS-CoV-2 significantly higher stomatitis susceptible Syrian Golden hamsters T cell Th1 Th2 triggered Vaccine vaccine candidate vesicular vesicular stomatitis virus VSV [DOI] 10.3390/v14061127 PMC 바로가기 [Article Type] Article
T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severityT 세포 수용체 시퀀싱은 이전 SARS-CoV-2 감염을 식별하고 중화 항체 및 질병 중증도와 상관관계가 있습니다Article Published on 2022-05-232022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adaptive Biotechnologies Adaptive immunity antibody blood sample breadth conducted correlated COVID-19 Decline diagnostics difficulty breathing disease severity evaluated Fever Frederick greater Hospitalization humoral identify immune response Improved individual induce Infection Infectious disease initial less magnitude NAb neutralizing antibody NIAID protective immunity response SARS-CoV-2 SARS-COV-2 infection sensitivity Sequencing serology serology test severe disease significantly Society Support T cell T cell receptor T cell response T cell responses TCR transplantation Trial undetectable [DOI] 10.1172/jci.insight.150070 PMC 바로가기 [Article Type] Article
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functionsmRNA-1273 및 BNT162b2 COVID-19 백신은 Fc 매개 효과기 기능에 차이가 있는 항체를 유도합니다Article Published on 2022-05-182022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody approved binding BNT162b2 cell activation Cohort Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Efficacy elicit epitope evade Fc-mediated effector function function functional functional capacity Hospital staff humoral immune response humoral immune responses IgA immune response immune responses Killer cell morbidity morbidity and mortality mRNA mRNA vaccines mRNA-1273 mRNA-1273 vaccine mRNA-1273 vaccines N-terminal N-terminal domain natural killer natural killer cell neutralization Neutralizing antibodies neutrophil phagocytosis potential differences protective immunity RBD Receptor binding domain recipient recipients reduced Region respiratory responses robust SARS-CoV-2 the vaccine the vaccines These data Vaccine Vaccines variants variants of concern Variation Viral viral variant Viral variants wake wild-type [DOI] 10.1126/scitranslmed.abm2311 PMC 바로가기 [Article Type] Article
Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants재조합 RBD 백신의 비강내 투여는 오미크론이 포함된 SARS-CoV-2 변이체에 대한 장기 면역을 유도합니다Article Published on 2022-05-172022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration booster Cell coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 deficiency demonstrated Economy effective vaccine Emergency global health Health IgG antibody immune response immune responses Immunity immunization induce intramuscularly intranasal Local long-lasting lung lymph nodes memory T cell memory T cells mice Migration mucosal mutant strain Neutralizing omicron Omicron variants outbreak persistence proliferation protective immunity RBD required respiratory robust SARS-CoV-2 SARS-CoV-2 variant secretory IgA sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Strains Strong suggested systemically T cells T-cell threat Vaccine vaccine candidate Vaccines variant variants waning immunity wild-type [DOI] 10.1038/s41392-022-01002-1 PMC 바로가기 [Article Type] Article
Association between history of HBV vaccine response and anti-SARS-CoV-2 spike antibody response to the BioNTech/Pfizer’s BNT162b2 mRNA SARS-CoV-2 vaccine among healthcare workers in Japan: A prospective observational study일본 의료 종사자들 사이에서 BioNTech/Pfizer의 BNT162b2 mRNA SARS-CoV-2 백신에 대한 HBV 백신 반응과 항 SARS-CoV-2 스파이크 항체 반응의 연관성: 전향적 관찰 연구Observational Study Published on 2022-05-162022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% confidence interval age Analysis anti-SARS-CoV-2 Antibody Response Antibody titer baseline BNT162b2 BNT162b2 mRNA BNT162b2 vaccine booster dose calculated Comorbidity comparable confidence interval COVID-19 pandemic defined dose doses faster follow-up study HBV healthcare healthcare worker immune response Inadequate long term non-responder participant Patient pharmaceutical prospective observational study protective immunity Protein recruited Responder responses against risk Roche S-protein SARS-CoV-2 SARS-CoV-2 vaccine second dose seroconvert seroconverted single dose tested university vaccination Vaccine vaccine response [DOI] 10.1371/journal.pone.0268529 PMC 바로가기 [Article Type] Observational Study