Evaluation of I-TAC as a potential early plasma marker to differentiate between critical and non-critical COVID-19Research Article Published on 2021-12-212022-10-31 Journal: Cell Stress [Category] COVID-19, [키워드] Analysis antibody collected Consequences COVID-19 COVID-19 cases COVID-19 pandemic Critical Critical disease cytokine disease severity ELISA FIVE Gasdermin B groups Health Hospitalization I-TAC Intervention IP-10 knowledge marker mitigate moderate molecular nine Patient patients with moderate plasma platform pyroptosis quantified Research resource SARS-CoV-2 severity significantly significantly higher ST2 symptom onset the disease to define unmet need upregulated [DOI] 10.15698/cst2022.01.262 PMC 바로가기 [Article Type] Research Article
Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and ApoptosisPhysiology Published on 2021-12-202022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Administered Anti-inflammatory antiapoptotic antioxidant Antioxidative Apoptosis Autoimmunity autophagy cell death cell membrane China chronic inflammatory diseases clinical trials Clinical use coronavirus COVID-19 Diseases Effect Effects Efficacy energy metabolism help hydrogen immune system injection Ischemia mechanism mitochondrial modulating molecular Molecular hydrogen molecular hydrogen (H2) molecule novel Novel coronavirus nuclear penetrate Pneumonia pyroptosis reactive oxygen species reactive oxygen specy Regulation reperfusion injury Respiratory disease Sepsis shown Spread therapeutic effect transcription factor Treatment treatment guideline variety [DOI] 10.3389/fphys.2021.789507 PMC 바로가기 [Article Type] Physiology
Inflammasomes and SARS-CoV-2 InfectionReview Published on 2021-12-142022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] “cytokine storm” activate Activation Adaptive immune response affected caused coronavirus COVID-19 COVID-19 patient Cytokines develop disease form function gasdermin D IL-18 IL-1β induce Inflammasome inflammasomes Inflammatory cell death influenza A virus innate immune response innate immune system Innate immunity Local majority mild respiratory symptoms mRNA vaccine multiple organ people with COVID-19 pro-inflammatory cytokine pro-inflammatory cytokines Protective Protein protein complex pyroptosis recent SARS-CoV-2 SARS-COV-2 infection secretion severe COVID-19 severe disease Structure systemic inflammation virus infection worldwide pandemic [DOI] 10.3390/v13122513 PMC 바로가기 [Article Type] Review
XDeathDB: a visualization platform for cell death molecular interactionsArticle Published on 2021-12-142022-10-04 Journal: Cell Death & Disease [Category] SARS, 변종, [키워드] aggregation Apoptosis article association associations BioGRID Cancer cancer type Cell cell death cell division Clustering collected COVID-19 database death disease DisGeNET Drug discovery DrugBank effector molecules Efferocytosis facilitate Ferroptosis hallmark identify immunogenic cell death Interaction intrinsic literature review lysosomal mitochondrial mitotic molecular interaction molecular mechanism necroptosis occur parthanatos pathway physiological cell death platform provide pyroptosis resource server Signaling subcellular target TTD user [DOI] 10.1038/s41419-021-04397-x PMC 바로가기 [Article Type] Article
Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets코로나바이러스 감염 관련 세포 사멸 신호 및 잠재적 치료 표적Review Published on 2021-12-092022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] (RdRp 3CLpro ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-apoptotic Anti-inflammatory antiviral properties Apoptosis assembly autophagy BCL-2 can be used caused celastrol cell death cell death pathways Chloroquine chloroquine/hydroxychloroquine Compound coronavirus CoV infection COVID-19 COVID-19 treatment Critical Curcumin cysteine Cytokines death deaths Effect Efficacy enzyme expression FIVE flavonoids Frame group Helicase host cell Hydroxychloroquine induce Infection Inflammation inhibiting inhibitor Inhibitory effects interactions involved L-cysteine life cycle mechanism mitigate modify molecular target molecules MPro name natural natural compounds necroptosis NF-κB NF-κB signaling NLRP3 inflammasome non-structural protein nonstructural protein 1 nsp1 Nsp12 occurred Open reading frame ORF7a outcomes Papain play roles PLPro Potential progression proliferation promote Propagation protease Protein proteinase pyroptosis RdRP Regulated cell death Replication responsible RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV infection SARS-CoV-2 SARS-CoV-2-infected patients Serine serine 2 severe acute respiratory syndrome Coronavirus Signaling small molecule specific inhibitor spike Spike protein survival target targeted therapy the disease therapeutic targeting TMPRSS2 TNF transmembrane transmembrane protease serine 2 Treatment variety Viral viral entry viral infection viral life cycle virions XIAP yielding [DOI] 10.3390/molecules26247459 PMC 바로가기 [Article Type] Review
Severe acute respiratory syndrome coronavirus 2 causes lung inflammation and injuryReview Published on 2021-12-012022-10-04 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome affected alveolar epithelial cells antiviral therapy asymptomatic infections cause caused Clinical practice consequence content coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm death develop effective future therapeutic Health health-care system immune response individual Inflammatory Inflammatory responses Injury lack lung damage Lung inflammation lung inflammatory response Lung injury mechanism mechanisms Middle East Mild molecular mechanism objective pathogenic pathway public health pyroptosis reference Research respiratory syndrome coronavirus SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severe disease Source thrombotic tissue repair Transmissibility Treatment [DOI] 10.1016/j.cmi.2021.11.022 PMC 바로가기 [Article Type] Review
Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus InfectionArticle Published on 2021-11-282022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] ACSL1 administration ameliorated Apoptosis approach C57BL/6 caused Cell coronavirus Coronavirus infection expression Ferroptosis Genes Hepatitis Host hyper-inflammation in vivo indicate induce inducer infected cells Infection Inflammatory cytokine inhibited inhibitor intranasal involved Lung inflammation lytic cell death Macrophage macrophages MHV-A59 mice mouse hepatitis virus (MHV) murine necroptosis pathogenicity performed Potential treatment PROTECT pyroptosis released RNA-Seq shown suppressed Syncytia syncytia formation targeting therapy tissue injury TLR4 upregulate upregulation viral propagation virus strain [DOI] 10.3390/v13122383 PMC 바로가기 [Article Type] Article
The Roles of Gasdermin D in Coronavirus Infection and EvasionMicrobiology Published on 2021-11-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] activate Activation Bacterial infection C-terminal Cancer caspase cellular plasma membrane cleavage coronavirus diseases Coronaviruses Critical cytosolic domain Evidence function gasdermin D GSDMD infections inflammasomes Inflammatory inhibitory innate immune Innate immunity Invasion investigated Last living cell mechanism microbial modify N-terminal programmed cell death Protein protein gasdermin D Proteins pyroptosis role secretion therapeutic potential virus virus infection viruses while [DOI] 10.3389/fmicb.2021.784009 PMC 바로가기 [Article Type] Microbiology
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB살모넬라 인판티스는 SopB에 의한 Akt의 간헐적 인산화로 감염된 상피 세포의 사멸을 지연시켜 세균 부하를 악화시킨다.Original Research Published on 2021-11-052024-07-29 Journal: Frontiers in immunology [Category] 살모넬라증, [키워드] AKT Apoptosis host-pathogen interactions Inflammation pyroptosis Salmonella Infantis SopB [DOI] 10.3389/fimmu.2021.757909 PMC 바로가기 [Article Type] Original Research
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patientsArticle Published on 2021-11-012023-06-12 Journal: Journal of medical virology [Category] B형 간염, [키워드] Hepatitis B virus pathological inflammation degree pyroptosis [DOI] 10.1002/jmv.27114