Standard of care for COVID-19 in randomized clinical trials registered in trial registries and published in preprint servers and scholarly journals: a cross-sectional study임상시험 레지스트리에 등록되고 인쇄전 서버 및 학술지에 게재된 무작위 임상 시험에서 COVID-19에 대한 치료 표준: 횡단면 연구Article Published on 2022-06-172022-09-11 Journal: BMC Medical Research Methodology [Category] COVID19(2023년), SARS, 임상, [키워드] administration analgesics Analysis Antibiotics antipyretics Antiviral bioRxiv Care clinical clinical trial clinical trials Combination component components conducted coronavirus Corticosteroid Corticosteroids COVID-19 cross-sectional cross-sectional study detrimental disease effective eligible for inclusion group Immunomodulatory agent Immunomodulatory agents Intervention investigator investigators MOST National original Original research oxygen pandemic randomized clinical trial Randomized controlled trial ranged RCT RCTs recruitment Registered reported SARS-CoV-2 shown SOC Standard Standard of care treated Treatment treatment for COVID-19 treatment intervention treatment interventions Trial trials unique Vitamin vitamins were used [DOI] 10.1186/s12874-022-01646-1 PMC 바로가기 [Article Type] Article
High Challenge Exercise and Learning Safe Landing Strategies among Community-Dwelling Older Adults: A Randomized Controlled TrialRandomized Controlled Trial Published on 2022-06-162022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] age baseline both groups challenge change control group Controlled COVID-19 pandemic decrease Effect effective evaluated exercise Follow-up functions Health status improvement in both group initiated Injury Intervention judo landing learning martial arts men motor skill offered Older Older adults participant physical physical activity physical activity level populations postintervention Psychological Randomized controlled trial Randomly RCT Research significantly Strategy sustained two groups women [DOI] 10.3390/ijerph19127370 PMC 바로가기 [Article Type] Randomized Controlled Trial
Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial연구 직원의 행동이 입원 환자 연구의 연구 결과에 미치는 영향(PINGPOng): 무작위 임상 시험을 위한 연구 프로토콜Article Published on 2022-06-132022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] administration Affect Alpha amylase analgesic Analgesic therapy analyzed Anxiety Behavior characteristic classical clinical clinical development clinical study clinical trial cold pressor test conducted cortisol covariate covariates cross-over Declaration of Helsinki Depression double-blind Drug efficacy Effect Effects Factor fixed healthy volunteer help Helsinki ICH-GCP influence intensity Neutral Oxycodone Pain pain intensity pharmacological phase Placebo Placebo effect Placebo response placebo-controlled study pressor test primary endpoint question Randomized randomized clinical trial RCT RCTs reaction response responses salivary single-center specific effect specific effects Stress study outcome Study protocol Study team. Symptom tested treated Treatment university [DOI] 10.1186/s13063-022-06436-0 PMC 바로가기 [Article Type] Article
Efficacy and harms of tocilizumab for the treatment of COVID-19 patients: A systematic review and meta-analysis코로나19 환자 치료를 위한 토실리주맙의 효능과 유해성: 체계적 고찰 및 메타분석Meta-Analysis Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] 임상, 진단, [키워드] 95%CI adverse event adverse events AEs all-cause mortality analyses antibody Arm ARMS benefit bleeding Clinical improvement Clinical outcome Cohort cohorts Controlled trial COVID-19 COVID-19 adult patient COVID-19 adult patients database disease severity Effect evaluated Evidence Hospitalized hospitalized COVID-19 patients IL-6 impacted inverse main analyses mechanical ventilation Meta-analysis methodology moderate neutropenia nine no significant difference Other outcome performed Placebo Primary outcomes Probability Quality Random-effects meta-analysis Randomized controlled trials RCT RCTs receptors reduced risk risk of bia RoB searched severe AEs significant difference significantly Standard of care Subgroup analyses subgroup analysis systematic review TCZ thrombotic thrombotic event Thrombotic events Tocilizumab Treatment Weighting worsening [DOI] 10.1371/journal.pone.0269368 PMC 바로가기 [Article Type] Meta-Analysis
Baricitinib in hospitalised patients with COVID-19: A meta-analysis of randomised controlled trialsResearch article Published on 2022-06-032022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 28-day mortality 95% CI Analysis Anti-inflammatory Anti-viral Baricitinib COVID COVID19 database death Dexamethasone discharge disease duration of hospitalisation ECMO Efficacy finding funding hospitalised patient improved mortality IMV inhibitor Invasive mechanical ventilation Jak Janus kinase Janus kinase inhibitors Meta-analysis outcome patients patients with COVID-19 performed positive pressure ventilation progression PROSPERO database random-effects model randomised controlled trial RCT reduce mortality reduced Registered Respiratory failure searched severe disease shown Standard of care Standard therapy statistically significant statistically significant reduction Tocilizumab Treatment with COVID-19 [DOI] 10.1016/j.eclinm.2022.101489 [Article Type] Research article
COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trialsCOVID-19 및 비타민 D(Co-VIVID 연구): 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-06-012022-09-11 Journal: Expert review of anti-infective therapy [Category] 임상, [키워드] 95% CI Area cholecalciferol ClinicalTrials Cochrane Library conducted Controlled trial COVID-19 COVID-19 patient COVID-19 patients COVID-19 susceptibility databases evaluate events Evidence expert group ICU admission indicated Intervention intervention group literature Meta-analysis Mortality outcome outcomes performed placebo group PROSPERO Randomized Randomized controlled trial Randomized controlled trials RCT RCTs Registered Relative risk reported risk RT-PCR SARS-CoV-2 severity significantly susceptibility systematic review Vitamin Vitamin D vitamin D levels with COVID-19 [DOI] 10.1080/14787210.2022.2035217 PMC 바로가기 [Article Type] Meta-Analysis
Antidepressants for COVID-19: A systematic reviewReview article Published on 2022-06-012022-10-05 Journal: Journal of affective disorders [Category] 임상, [키워드] antidepressant antidepressants Chinese Clinical deterioration Cochrane Library coronavirus disease COVID-19 COVID-19 patient COVID-19 patients determine dropout rate Efficacy and safety Evidence examined fluvoxamine hospitalisation journal Mortality objective patients with COVID-19 Placebo prospective cohort study PsycINFO randomized clinical trial RCT RCTs reduced reducing researcher Result retrospective Retrospective study risk supported systematic review Treatment was performed [DOI] 10.1016/j.jad.2022.03.059 [Article Type] Review article
Efficacy of early use of remdesivir: a systematic review of subgroup analysis렘데시비르 조기 사용의 효능: 하위 그룹 분석의 체계적인 검토Article Published on 2022-06-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] 치료제, [키워드] Analysis applicability benefit biological plausibility caution checklist clinical decision-making Clinical improvement Clinical practice Clinical status score clinical trial clinical trials conditions Consistency Coronavirus 2019 coronavirus disease Coronavirus disease 2019 COVID-19 cut-off database Drug evaluation early treatment Efficacy Efficiency Endpoint English evaluate FIVE Future greater Healthcare systems heterogeneity Interpretation material methodological methodology Patient provide question RCT RCTs recommendation Remdesivir Result second selected severe coronavirus disease severe COVID-19 significantly Spanish statistical interaction subgroup analysis subset suggested Symptom symptom onset Symptoms systematic review Treatment variable was performed were assessed [DOI] 10.37201/req/154.2021 PMC 바로가기 [Article Type] Article
Comparing the efficacy of tocilizumab with corticosteroid therapy in treating COVID-19 patients: a systematic review and meta-analysisCOVID-19 환자 치료에서 토실리주맙과 코르티코스테로이드 요법의 효능 비교: 체계적인 검토 및 메타 분석Review Published on 2022-06-012022-09-12 Journal: Daru : journal of Faculty of Pharmacy, Tehran Univ [Category] COVID19(2023년), SARS, 진단, [키워드] 95%CI baseline characteristics Case-control case-control studies case-control study Combination contributed Corticosteroid corticosteroid therapy COVID-19 database determinant Dexamethasone did not reduce dose regimen drug Drug efficacy Efficacy Factor High dose identify IMPROVE mechanical ventilation Meta-analysis Methylprednisolone Mortality outcome Patient patients pulse Randomized Randomized controlled trial randomized trials RCT RCTs reduce reducing mortality reduction searched severe COVID-19 patients shown significantly systematic review therapeutic therapy Tocilizumab treating COVID-19 was performed [DOI] 10.1007/s40199-021-00430-8 PMC 바로가기 [Article Type] Review
High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trialRandomized Controlled Trial Published on 2022-05-312022-10-04 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] adjusted hazard ratio Administered administration adverse effect age anti-infective drugs baseline benefit cancers conducted confidence interval contraindication coronavirus 2 COVID-19 criteria death delirium diagnosis of COVID-19 diarrhea died early administration eligibility eligibility criteria eligible France High dose High-dose high-dose group hospital Hospitalization ICU improves intention-to-treat population investigator involved IQR less limitation Local median age medical supervision Mortality multicenter observational studies Older older patient Open-label open-label design Organ failure outcome overall mortality oxygen Oxygen requirement paO2/fiO2 participant Patient Primary outcome Prognostic factor protective effect randomization Randomized Randomized controlled trial Randomly RCT respiratory risk factor Safety Monitoring Board SARS-CoV-2 SARS-COV-2 infection Sex SpO2 Standard dose Standard-dose steering committee survival sustained treat Treatment Trial use of antibiotics Vitamin D Vitamin D supplementation vitamin D supplements were assessed with COVID-19 women worsening [DOI] 10.1371/journal.pmed.1003999 PMC 바로가기 [Article Type] Randomized Controlled Trial