Impact of previous exposure to SARS-CoV-2 and of S-Trimer (SCB-2019) COVID-19 vaccination on the risk of reinfection: a randomised, double-blinded, placebo-controlled, phase 2 and 3 trialSARS-CoV-2 및 S-Trimer(SCB-2019) COVID-19 백신에 대한 이전 노출이 재감염 위험에 미치는 영향: 무작위 배정, 이중 맹검, 위약 대조, 2상 및 3상 시험Clinical Trial Published on 2022-07-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 1:1 95% CI addition Alpha assigned attack rates B.1.1.7 B.1.351 B.1.617.2 B.1.621 baseline Beta calculate CEPI Clover Coalition confirmed case COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine dose double-blind double-blinded Efficacy enrolled Evidence evidence of exposure to FIVE groups hospitalisation Impact injection site pain Innovation IQVIA Lambda Local lowest moderate-to-severe COVID-19 multicentre no evidence of P.1 participant Participants Phase 2 Placebo placebo-controlled placebo-controlled trial Primary outcome Primary outcomes protection Protective randomised Randomly Rate reactogenicity Real-time PCR receive recipients recombinant Reinfection reported response risk SARS-CoV-2 SARS-CoV-2-naïve participants SCB-2019 Secondary analyses secondary analysis Serious Adverse Event Serious Adverse Events severe adverse events severe COVID-19 severity subsequent subset symptomatic systemic adverse event systemic adverse events technology Trial USA vaccination Vaccine vaccine dose vaccine efficacy variant variants Viral variants with COVID-19 [DOI] 10.1016/S1473-3099(22)00144-X PMC 바로가기 [Article Type] Clinical Trial
Saliva versus Upper Respiratory Swabs: Equivalent for Severe Acute Respiratory Syndrome Coronavirus 2 University Screening while Saliva Positivity Is Prolonged After Symptom Onset in Coronavirus Disease 2019 Hospitalized Patients타액 대 상부 호흡기 면봉: 중증 급성 호흡기 증후군 코로나바이러스 2 대학 선별 검사에 해당하며 코로나바이러스 질병 2019 입원 환자의 증상 발병 후 타액 양성이 연장됨Article Published on 2022-07-012022-09-11 Journal: The Journal of molecular diagnostics : JMD [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Asymptomatic Cohort collected comparable coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 equivalent faculty hospital hospitalized patient hospitalized patients nare offer Onset pandemic populations positive Prolonged proportion Real-time PCR reopening respiratory Saliva SARS-CoV-2 SARS-CoV-2 detection School Schools Screening screening methods sensitivity severe acute respiratory syndrome Coronavirus specimen study cohort Swab symptom onset symptomatic symptomatic and asymptomatic symptomatic COVID-19 tested university University of Pennsylvania upper upper respiratory [DOI] 10.1016/j.jmoldx.2022.03.012 PMC 바로가기 [Article Type] Article
Evaluation of Four Point of Care (POC) Antigen Assays for the Detection of the SARS-CoV-2 Variant OmicronSARS-CoV-2 변이체 오미크론 검출을 위한 4가지 진료 시점(POC) 항원 분석 평가Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Abbott Analysis analytical sensitivity Antigen assays Asymptomatic average Cell culture contributing to correlated Cycle threshold value ddPCR Delta delta variant detect detectable detection diagnostics digital PCR Dilution discrepancies discrepancy Ensuring evaluated Genome highest Infectious virus infectious virus titer limit limit of detection LOD log manuscript molecular N gene omicron Omicron variant POC Point point of care point-of-care positive quantified Rapid antigen tests Real-time PCR reduced replicate RNA SARS-CoV-2 specimen Spread swab sample symptomatic tested the SARS-CoV-2 vaccinated individuals variant variant of SARS-CoV-2 Viral viral stock viral stocks virus stock virus titer [DOI] 10.1128/spectrum.01025-22 PMC 바로가기 [Article Type] Article
Alinity m, a Random-Access System, for Hepatitis B Virus DNA Quantification in Plasma and Whole Blood Collected on Dried Blood SpotsArticle Published on 2022-06-292023-06-11 Journal: mSphere [Category] B형 간염, [키워드] dried blood spot HBV DNA Hepatitis B virus Real-time PCR Whole blood [DOI] 10.1128/msphere.00082-22 PMC 바로가기
Comparison of demographic, clinical and laboratory characteristics between first and second COVID-19 waves in a secondary care hospital in Qatar: a retrospective studyObservational Study Published on 2022-06-282022-10-04 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] Antibiotics Antigen Antiviral chest X-ray clinically combination therapy conducted cough COVID-19 COVID-19 pandemic discharged home Diseases Dyspnoea Epidemiology Final First wave greater handling hospital hospitalisation Hydroxychloroquine incidence Infection Infectious diseases laboratory characteristics Laboratory parameters Length mechanical ventilation Mortality Nasopharyngeal swab Negative PCR outcome pandemic Patient patients with COVID-19 peripheral oxygen saturation Pneumonia positive COVID-19 Real-time PCR required respiratory rate retrospective Retrospective study SARS-COV-2 infection second second wave secondary care significantly higher Steroids supplemental oxygen Symptom the patient were excluded [DOI] 10.1136/bmjopen-2022-061610 PMC 바로가기 [Article Type] Observational Study
Evaluation of a commercial SARS-CoV-2 multiplex PCR genotyping assay for variant identification in resource-scarce settings자원이 부족한 환경에서 변이체 식별을 위한 상용 SARS-CoV-2 다중 PCR 유전자형 분석 평가Article Published on 2022-06-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African Analysis approaches Beta Beta variant beta variants characterization circulating circulating SARS-CoV-2 variant circulating variant circulating variants complement Concordance coronavirus COVID-19 Delta delta variant Delta variants demonstrated evaluated exhibited genomic sequencing genotyped genotyping globe gold gold standard multiplex Multiplex PCR offer omicron Omicron variant pathogenic variant PCR assay Real-time PCR real-time PCR assay reproducibility SARS-CoV-2 SARS-CoV-2 surveillance SARS-CoV-2 variant SARS-CoV-2 variants sensitivity South South Africa South Korea specificity specimen Spread Surveillance variant variants WGS whole genome Whole genome sequencing whole-genome sequencing [DOI] 10.1371/journal.pone.0269071 PMC 바로가기 [Article Type] Article
Survival of SARS-CoV-2 and bovine coronavirus on common surfaces of living environments생활 환경의 공통 표면에서 SARS-CoV-2 및 소 코로나바이러스의 생존Article Published on 2022-06-232022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol Aerosols Bovine coronavirus Contamination coronavirus decrease Infectious virus limit of detection living environment Masks nitrile porous Real-time PCR remained RNA Saliva SARS-CoV-2 severe acute respiratory syndrome Coronavirus substrate substrates Survivability survival tested transmitted viral titer viral titers virus were measured [DOI] 10.1038/s41598-022-14552-9 PMC 바로가기 [Article Type] Article
Current RT-qPCR to detect SARS-CoV-2 may give positive results for related coronavirusesSARS-CoV-2를 검출하기 위한 현재 RT-qPCR은 관련 코로나바이러스에 대해 긍정적인 결과를 제공할 수 있습니다Article Published on 2022-06-232022-09-11 Journal: Archives of Microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] amplification applied Coronaviral coronavirus current detect epidemiological epidemiological surveillance False positives Genome genomic sequence Health Health Organization in vitro MONITOR outbreak pandemic performed phylogenetically positive positive result Prevalence protocol qPCR Real-time PCR Reverse transcription qPCR RT-qPCR SARS-CoV-2 specificity Surveillance Test Transcription virus World Health Organization [DOI] 10.1007/s00203-022-03029-y PMC 바로가기 [Article Type] Article
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vapingCOVID-19의 신경 전달 및 흡연 및 전자담배에 의한 신경염증 상태에서 성상교세포 안지오텐신 전환 효소 2의 잠재적 역할Article Published on 2022-06-072022-09-11 Journal: Fluids and Barriers of the CNS [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 expression affecting Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Astrocyte astrocytes Brain Cell cell type cells characterized Choroid plexus conducted COVID-19 COVID-19 patients COVID-19 severity cultured cells cytokine distribution domain endothelial cells entry receptor enzyme epithelial cell epithelial cells evaluate the effect exacerbate exacerbated expressed expression glial cell help highlight hypothalamus IL-5 IL-6 Immunocompromised immunohistochemistry immunomodulatory Inflammation manifestation marker Medulla oblongata meninges neural transmission Neurogenesis Neuron neurons Nicotine oblongata Pathogenesis pathogenesis of COVID-19 pericytes Post-infection Potential proinflammatory Real-time PCR responsible risk factor SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection shown significantly Smokers smoking stroma systemically third ventricle Transmission understanding ventricular were used western blot zone [DOI] 10.1186/s12987-022-00339-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Whole-Genome Sequencing by Ion S5 Technology-Challenges, Protocol Optimization and Success Rates for Different StrainsIon S5 기술에 의한 SARS-CoV-2 전체 게놈 시퀀싱 - 다양한 균주에 대한 과제, 프로토콜 최적화 및 성공률Article Published on 2022-06-062022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Amplicon arise assigned cDNA Concentration construction COVID-19 COVID-19 pandemic demonstrated diagnostics Effectiveness Emergency genomic data idea immunization Ion less library library preparation lineages Modification molecular Molecular epidemiology mRNA mRNA or viral vector vaccines Mutation Next-generation sequencing NGS optimization Panel Patient Poland produced protocol Public public health emergency Rate Real-time PCR required RT-PCR SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage SARS-CoV-2 sequencing Scientific community Sequencing strain Support Surveillance Thermo Fisher Scientific variant variants variants of concern Viral Viral load Viral RNA Viral vector vaccines whole-genome whole-genome sequencing [DOI] 10.3390/v14061230 PMC 바로가기 [Article Type] Article