Outcomes of tocilizumab therapy in severe or critical COVID-19 patients: A retrospective cohort, single-centre study중증 또는 중증 COVID-19 환자에서 토실리주맙 요법의 결과: 후향적 코호트, 단일 센터 연구Article Published on 2021-12-012022-09-12 Journal: Tropical medicine & international health : TM & IH [Category] MERS, SARS, 진단, [키워드] adjusted hazard ratio antibody C-reactive protein Clinical improvement clinically COVID-19 Critical critical COVID-19 patient critical COVID-19 patients D-dimer Effectiveness ferritin level Follow-up greater group hospital in-hospital mortality in-hospital mortality rate intravenous tocilizumab Kuwait lactate dehydrogenase likelihood median Mortality occurred Patient patients procalcitonin receptor reduced risk regression analysis retrospective cohort retrospective cohort study Secondary infection severe coronavirus disease significantly significantly lower Standard of care Standard-of-care statistical significance survival TCZ Tocilizumab tocilizumab therapy Treatment [DOI] 10.1111/tmi.13685 PMC 바로가기 [Article Type] Article
Emotional status and fear in patients scheduled for elective surgery during COVID-19 pandemic: a nationwide cross-sectional survey (COVID-SURGERY)Original Article Published on 2021-11-252022-10-30 Journal: Journal of Anesthesia, Analgesia and Critical Care [Category] COVID-19, [키워드] age anaesthesia being cardiovascular disease chronic disease Cohort Contagion COVID-19 COVID-19 pandemic cross-sectional survey disease drugs Elective surgery emotional Emotional status evaluate Factor higher risk hospital Hospital admission hospitalised Hospitalization IMPROVE increased risk Infection involved Italian Italy males multicentre outcome pandemic participant Patient patients Perioperative medicine Population Psychological distress receive reduced risk Result SARS-CoV-2 SARS-COV-2 infection supplementary material Support surgical survey the patient Volume with COVID-19 [DOI] 10.1186/s44158-021-00022-7 PMC 바로가기 [Article Type] Original Article
Impact of androgen deprivation therapy on mortality of prostate cancer patients with COVID-19: a propensity score-based analysisResearch Article Published on 2021-11-252022-10-30 Journal: Infectious Agents and Cancer [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome adjusted Analysis analyzed Androgen antagonists Androgen receptor antagonists antineoplastic agents association Cohort Control coronavirus COVID-19 death Deprivation died Final GnRH Impact less Mortality MOST Patient patients hospitalized patients with COVID-19 performed previous study Prostate cancer protective factor public health reduce reduced risk reductions in Result Retrospective analysis robust supplementary material survival therapy treat Treatment variable were used [DOI] 10.1186/s13027-021-00406-y PMC 바로가기 [Article Type] Research Article
Effectiveness of Regdanvimab Treatment in High-Risk COVID-19 Patients to Prevent Progression to Severe Disease중증 질환으로의 진행을 예방하기 위한 고위험 COVID-19 환자에서 Regdanvimab 치료의 효과Immunology Published on 2021-11-232022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] 95% CI Analysis clinical effectiveness Cohort cohorts conducted Coronavirus 2019 COVID-19 COVID-19 patient CRP discharge Disease progression enrolled evaluate Factors groups hospital investigated mild COVID-19 patient monoclonal antibody multivariate nasal objective outcome Patient Potential progression reduced risk regdanvimab required Result retrospective cohort study risk risk factor Seven severe disease significantly significantly lower statistically significant study period Support supportive care symptom onset the patient Treatment [DOI] 10.3389/fimmu.2021.772320 PMC 바로가기 [Article Type] Immunology
Retrospective cohort study to evaluate medication use in patients hospitalised with COVID-19 in Scotland: protocol for a national observational study스코틀랜드에서 COVID-19로 입원 한 환자의 약물 사용을 평가하기위한 후 향적 코호트 연구 : 국가 관찰 연구를위한 프로토콜Pharmacology and Therapeutics Published on 2021-11-192022-09-10 Journal: BMJ Open [Category] Fulltext, MERS, SARS, 치료제, [키워드] Administered Analysis approval board caused changes in choice clinical pharmacology clinical trials cohort study Committee COVID-19 death described description Dexamethasone dissemination Dose escalation drug East estimation Ethics evaluate Evidence example exploratory exposure to finding FIVE hospital hospitalisation hospitalisations hospitalised In-hospital Infection information knowledge medication Medicine Medicines National outcomes Panel Patient peer-reviewed platform Prevent Primary outcome privacy protocol Public real-world data receiving reduced risk Release Remdesivir Repurposed drug Research Ethics retrospective cohort study routine clinical practice SARS-COV-2 infection Scottish service severe COVID-19 South Surveillance switching Therapeutics Tocilizumab treated Treatment Vaccine website with COVID-19 [DOI] 10.1136/bmjopen-2021-054861 PMC 바로가기 [Article Type] Pharmacology and Therapeutics
Does COVID-19 infection change the need for future surgical interventions? An exploratory analysis.Brief Report Published on 2021-11-172022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] 95%CI adjusted appear baseline Canada Cohort collected data conducted Confidence intervals control group COVID-19 COVID-19 infection disease exclusion Exploratory analysis hazard ratio identify individual Infection performed reduced reduced risk renal Renal stone disease reported retrospective cohort study SARS-CoV-2 significantly surgery surgical Surgical Procedure Swab transurethral Treatment [DOI] 10.12688/f1000research.74861.1 PMC 바로가기 [Article Type] Brief Report
Effect of Intubation Timing on the Outcome of Patients With Severe Respiratory Distress Secondary to COVID-19 PneumoniaAnesthesiology Published on 2021-11-162022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 24 hour acute respiratory distress syndrome [ards] airway intubation Analysis analyzed baseline characteristics benefit Comorbidities coronavirus disease COVID-19 covid-19 respiratory failure Critically ill patient death deteriorate Detroit discharge distress Effect group groups healthcare providers Henry Ford High flow nasal canula higher risk hospital Hospital admission intensive care Intubated intubation Kaplan-Meier Kaplan-Meier survival curves mechanical ventilation Mortality nasal Observational cohort study observé organ dysfunction Organ failure outcome outcomes overall mortality Oxygenation pandemic Patient patients with COVID-19 performed Pneumonia post-hoc analysis Primary outcome question raised reduced risk respiratory respiratory rate Result Resuscitation retrospective risk ROX ROX index secondary secondary to Severe COVID-19 pneumonia Severe respiratory distress severe respiratory failure severe respiratory illness Significant significant difference significantly significantly higher significantly lower significantly more single-center SOFA SOFA score statistically significant difference subgroup of patient survival the timing therapy treated Treatment Ventilation while [DOI] 10.7759/cureus.19620 PMC 바로가기 [Article Type] Anesthesiology
Tocilizumab in the treatment of COVID-19-a meta-analysisCOVID-19의 치료에서 Tocilizumab - 메타 분석Meta-Analysis Published on 2021-11-052022-09-12 Journal: QJM: An International Journal of Medicine [Category] SARS, 진단, [키워드] 95% CI 95% confidence interval administration Admission adverse event all-cause mortality benefit conducted coronavirus disease COVID-19 COVID-19 infection Critical Critically ill patient critically ill patients death demonstrated Endpoint evaluate hospitalized COVID-19 patients ICU ICU admission independent inhibitor intensive care interleukin-6 mechanical ventilation Meta-analysis Mortality outcome Patient patients performed Randomized controlled trial RCT RCTs reduce reduced reduced risk reduction in Relative risk Research Risk of bias screened Sensitivity analyses severe COVID-19 significant difference significantly significantly lower steroid subgroup analysis systematic review TCZ Tocilizumab Treatment Trial were used with COVID-19 [DOI] 10.1093/qjmed/hcab142 PMC 바로가기 [Article Type] Meta-Analysis
Effect of famotidine on hospitalized patients with COVID-19: A systematic review and meta-analysisCOVID-19를 가진 입원 환자에 대한 Famotidine의 영향 : 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-11-042022-09-10 Journal: PLoS ONE [Category] SARS, 임상, [키워드] 95% CI Admissions aggregate aims association calculated Care Clinical outcome clinical outcomes conducted controlled trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients database death determine Effect Efficacy Efficacy and safety endpoints Famotidine gastric acid hazard ratio help heterogeneity Histamine Hospitalization Hospitalized hospitalized patient hospitalized patients identify individuals with COVID-19 intensive care intubation lack Meta-analysis Mortality observational studies observational study Odds ratio outcome Patient patients treated point estimate point estimates power primary clinical outcome protective effect Randomized controlled trial ranged RCTs reduced risk reported Result risk searched separated suggested systematic review the disease thought total patient Treatment treatment for COVID-19 with COVID-19 [DOI] 10.1371/journal.pone.0259514 PMC 바로가기 [Article Type] Meta-Analysis
Periodontal Diseases: Major Exacerbators of Pulmonary Diseases?Review Article Published on 2021-11-022022-10-29 Journal: Pulmonary Medicine [Category] COVID-19, [키워드] Affect age association Asthma Bacteria changes in chronic obstructive condition contribute COPD COVID-19 disease Diseases disorders event Factors Frequency Genetic gingivitis Inflammatory responses Intervention lung Lung function Lungs Major microorganism morbidity Mortality Numerous oral disease outcome outcomes periodontal periodontal disease Periodontitis Pneumonia poor quality pulmonary pulmonary disease pulmonary diseases reduced risk significantly spirometry therapy tissue Topic Tuberculosis Volume [DOI] 10.1155/2021/4712406 PMC 바로가기 [Article Type] Review Article