Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model피내 전달 DNA 백신은 붉은털 원숭이 SARS-CoV-2 챌린지 모델에서 바이러스 부하 감소를 매개하는 내구성 면역을 유도합니다Article Published on 2021-09-282022-09-12 Journal: Cell Reports Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] Abstract adaptive immune system ADCD ADCP anti-SARS-CoV-2 Antigen Arm caused cellular challenge clinical trials clinically coronavirus Coronavirus disease 2019 COVID-19 COVID-19 disease DNA vaccine Efficacy Electroporation evaluated humoral humoral immune response ID DNA vaccine immune immune response Immunity immunization induce Infectious disease INO-4800 lung macaque neutralized neutralizing antibody responses protection Protective pseudotype viruses public health RBD binding antibody recall reduced viral load reduction in regimen respond response resulting rhesus rhesus macaque SARS-CoV-2 SARS-CoV-2 spike Spike protein Support the SARS-CoV-2 the SARS-CoV-2 virus vaccination vaccine dose Viral load [DOI] 10.1016/j.xcrm.2021.100420 PMC 바로가기 [Article Type] Article
Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaquesResearch Article Published on 2021-09-222022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] A.23.1 absence anatomical animal model animal models antibody Antibody-dependent cellular phagocytosis Antigen Beta binding Cellular immune response Control correlated Delta demonstrated develop dissemination DNA DNA vaccine effective Efficacy effort Electroporation elicited Epsilon Eta expressing Gamma highest humans humoral Humoral immunity Immunity in vitro include induce Intramuscular injection Lower respiratory tract mRNA-based vaccine nasal mucosa neutralized Neutralizing neutralizing antibody Neutralizing antibody titer Protective protective immune response Protein provide regimen responses rhesus rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-COV-2 infection spike T cell response T cell responses tested the SARS-CoV-2 the Spike trials Vaccine variant virus virus level Wuhan-Hu-1 [DOI] 10.1371/journal.ppat.1009701 PMC 바로가기 [Article Type] Research Article
Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola렘데시비르가 실패한 이유: 전임상 가정이 COVID-19 및 에볼라에 대한 렘데시비르의 임상 효능을 과대평가함Article Published on 2021-09-172022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 치료제, [키워드] anticipated approved assumption benefit clinical Clinical efficacy Clinical improvement clinically control groups coronavirus disease Coronavirus disease 2019 COVID-19 curative Drug efficacy Ebola Efficacy evaluate FDA GS-441524 GS-5734 humans in vitro in vitro models in vivo in vivo models investigational agent limitation metabolism Mortality nonhuman primates Patient pharmacokinetics Preclinical preclinical data prodrug Remdesivir rhesus rhesus macaque robust statistically significant difference Toxicity Trial [DOI] 10.1128/AAC.01117-21 PMC 바로가기 [Article Type] Article
Immunogenicity and Efficacy of Live-Attenuated Salmonella Typhimurium Vaccine Candidate CVD 1926 in a Rhesus Macaque Model of Gastroenteritis위장염의 리수스 원숭이 모델에서 생백신화된 살모넬라 장티푸스 백신 후보 CVD 1926의 면역원성과 효능Article Published on 2021-09-162024-08-21 Journal: Infection and Immunity [Category] 살모넬라증, [키워드] diarrhea gastroenteritis Gastrointestinal infection oral vaccines rhesus macaque Salmonella Salmonella Typhimurium Vaccine
Dual-Antigen COVID-19 Vaccine Subcutaneous Prime Delivery With Oral Boosts Protects NHP Against SARS-CoV-2 Challenge이중 항원 COVID-19 백신 경구 부스트가 포함된 피하 프라임 전달은 SARS-CoV-2 도전으로부터 NHP를 보호합니다Immunology Published on 2021-09-162022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] 24 hour 24 hours Adenovirus Against anti-S IgG boost challenge COVID-19 COVID-19 vaccine delivery demonstrated dual antigen effective elicited enhanced followed by fusion helper cell Immunity inhibited injection Lower respiratory tract lung MHC class MHC class II nasal passages Neutralizing NHP non-human primate (NHP) oral platform protection Protein respiratory responses rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 challenge SARS-CoV-2 spike protein serotype Spike protein Stimulation Subcutaneous T helper cell T-cell T-cell Response T-cell responses TCID the viral nucleocapsid undetectable upper and lower respiratory tracts Vaccine vaccine antigen Viral viral replication [DOI] 10.3389/fimmu.2021.729837 PMC 바로가기 [Article Type] Immunology
Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2CXCR3+ 세포의 염증 유발 미세 환경 및 전신 축적은 SARS-CoV-2에 감염된 늙은 붉은털 원숭이의 폐 병리를 악화시킵니다.Article Published on 2021-09-012022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Apoptosis autophagy both lungs CD8+ cell CD8+ cells Cell cells changes in Chemokine receptor coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCR3 demonstrated elevated exacerbate feature FFPE formalin formalin-fixed paraffin-embedded IFN-α IL-6 immunopathological immunopathology infected with SARS-CoV-2 Infection Infectious diseases interferon interleukin interleukin 6 lung Lung pathology lung tissue Lungs microenvironment motif multiplex immunofluorescence NF-κB nuclear paraffin Peripheral blood pro-inflammatory protein expression Quantitative analysis respiratory rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 significantly staining T cell T-box tissue Treatment understanding [DOI] 10.1038/s41392-021-00734-w PMC 바로가기 [Article Type] Article
Resolution of hepatitis E virus infection in CD8+ T cell-depleted rhesus macaquesArticle Published on 2021-09-012023-06-12 Journal: Journal of hepatology [Category] E형 간염, Fulltext, [키워드] CD4+ and CD8+ T lymphocyte Depletion hepatitis E virus rhesus macaque [DOI] 10.1016/j.jhep.2021.04.036 PMC 바로가기
Immunological evaluation of an inactivated SARS-CoV-2 vaccine in rhesus macaquesResearch article Published on 2021-08-262022-10-05 Journal: Molecular Therapy [Category] 비임상, [키워드] acute respiratory syndrome Analysis Antibody Response booster coronavirus coronavirus disease COVID-19 effective elicited formaldehyde immune response immunization immunized immunological immunopathological damage inactivated Inactivated vaccine inactivation individual inhibiting viral replication macaque macaques mice Pathogenesis performed produced PROTECT Protective rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 vaccine T cell response tested Vaccine Vaccine development Viral antigen viral challenge [DOI] 10.1016/j.omtm.2021.08.005 [Article Type] Research article
Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models비강 내 ChAdOx1 nCoV-19/AZD1222 백신 접종은 전임상 모델에서 SARS-CoV-2 D614G 공격 후 바이러스 발산을 감소시킵니다Article Published on 2021-08-182022-09-11 Journal: Science Translational Medicine [Category] SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenovirus-based Administered animal models approved Bronchoalveolar lavage ChAdOx1 ChAdOx1 nCoV-19 Contact contact with coronavirus COVID-19 vaccines D614G mutation did not reduce direct contact hamster hamsters Infectious virus intramuscular vaccination intranasally investigated Lower respiratory tract lung tissue macaque nasal swab nasal swabs Pneumonia Previous studies previous study provided reduce reduced reduction in rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 D614G severe acute respiratory syndrome Coronavirus shedding Spike protein Swab swabs the spike protein tissue upper respiratory tract vaccination Vaccine Viral load viral loads Viral RNA viral shedding virus virus concentration [DOI] 10.1126/scitranslmed.abh0755 PMC 바로가기 [Article Type] Article
ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge modelsArticle Published on 2021-07-262022-10-04 Journal: Communications Biology [Category] SARS, 진단, [키워드] absence administration animal model AZD1222 caused ChAdOx1 nCoV-19 clinical evaluation disease disease symptom ferret ferrets High dose Immune profile immune profiling immune response induce intramuscular Live attenuated vaccines Lung pathology neutralising antibody response Pneumonia reduce reduced required rhesus rhesus macaque SARS CoV-2 SARS-CoV-1 SARS-CoV-2 second dose subsequent Support the vaccine Thomas titre vaccination Vaccine Vaccine development viral infection virus [DOI] 10.1038/s42003-021-02443-0 PMC 바로가기 [Article Type] Article