A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease게놈 규모의 RNA-간섭 스크린은 헌팅턴병의 병리학적 특징으로 RRAS 신호를 식별합니다Research Article Published on 2012-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition Amino acid amino-terminus Analysis Author cascade caused Cell cellular cellular processe cellular processes component disease disorder Drosophila dysfunction effective ENCODE enzyme excitotoxicity farnesyltransferase FNTA found functional Glutamate Glutamine huntingtin Huntington's disease identify implicated in addition to increase in inhibitor Interaction Intervention involved Localization loss-of-function mammalian mechanism mechanisms mitochondrial mitochondrial dysfunction motor dysfunction mouse model mutant Mutation observé occur pathogenic pathway Pathways pharmacological PIN1 PLK1 Protein proteolysis RAF1 reduce reduced reducing repeated RNA interference RRAS Screen Signaling signaling pathway small molecule solubility suppress suppressed suppressor Therapeutic benefit These data Toxicity was performed [DOI] 10.1371/journal.pgen.1003042 PMC 바로가기 [Article Type] Research Article
Anti-HBV efficacy of combined siRNAs targeting viral gene and heat shock cognate 70Research Published on 2012-11-162023-08-29 Journal: Virology Journal [Category] E형 간염, [키워드] Combinational RNAi Heat shock cognate 70 Hepatitis B virus RNA interference short hairpin RNA [DOI] 10.1186/1743-422X-9-275 PMC 바로가기 [Article Type] Research
In vitro inhibition of transmissible gastroenteritis coronavirus replication in swine testicular cells by short hairpin RNAs targeting the ORF 7 geneResearch Published on 2012-08-282022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Apoptosis approach assays Cell cell proliferation characterized contagious Coronavirus replication Cytopathic effect demonstrated diarrhea effective Efficiency Evidence examined expressing expression expression plasmid expression plasmids gastroenteritis Genome high mortality in vitro indicated Infection inhibit inhibited inhibitory effect N gene ORF ORF 7 Quantitative Replication reporter Result RNA RNA interference RT-PCR analysis selected sequence short hairpin RNA shown significantly specificity STABLE target gene TCID TGEV the vaccine therapeutic transmissible gastroenteritis virus Treatment viral disease viral infections viral replication virus virus replication virus titer vomiting [DOI] 10.1186/1743-422X-9-176 PMC 바로가기 [Article Type] Research
Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infectionShort Report Published on 2007-06-072022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] affected appear blocking coronavirus COX Cyclooxygenase different different cells early stage Infection inhibitor investigated MHV mouse hepatitis mouse hepatitis virus Pathogenesis progeny reduced Replication required RNA interference subsequent therapy viral infection Viral protein Viral RNA virus production [DOI] 10.1186/1743-422X-4-55 PMC 바로가기 [Article Type] Short Report