The Potential Role of Super Spread Events in SARS-COV-2 Pandemic; a Narrative ReviewReview Article Published on 2020-09-212022-10-27 Journal: Archives of Academic Emergency Medicine [Category] COVID-19, [키워드] acute respiratory syndrome addressed article Community composed conducted Consequences Coronaviridae family coronavirus cost of illness COVID-19 disease disease outbreaks effective effort eligible Epidemics event group Health help Host humans investigated mass vaccination Measures narrative natural selection outbreak pandemic Pandemics Potential recombination event required review role screening strategy severe acute respiratory syndrome coronavirus 2 Specific Spread stages the disease PMC 바로가기 [Article Type] Review Article
Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patientsOriginal Article Published on 2020-09-022022-10-28 Journal: Aging Clinical and Experimental Research [Category] COVID-19, MERS, SARS, [키워드] 25-hydroxyvitamin D 95% CI 95% confidence interval a metric adaptive association average C-reactive protein C-reactive protein (CRP calculated Case mortality ratio Complication Concentration confirmed case country COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients CRP cytokine production Cytokine storm Deceased deficiency determine Evidence healthy subject individual Inflammation investigated Mortality objective Odds ratio Patient prevalence of COVID-19 reducing Result SARS-CoV-2 screening strategy severe COVID-19 severe COVID-19 patient severe COVID-19 patients the mean Vitamin D Vitamin D status was used [DOI] 10.1007/s40520-020-01677-y PMC 바로가기 [Article Type] Original Article
Screening Strategies for COVID-19 in Patients With Hematologic MalignanciesOncology Published on 2020-07-032022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] Cancer cancers Community Comorbidities complex Complication coronavirus COVID-19 CT scan Health Organization help hematologic hematologic malignancies Hematologic malignancy hematology higher risk highlight immune dysregulation infection risk limit malignancies malignancy management oncology pandemic Patient polymerase chain reaction Screening screening strategy severe complication Strategy therapy unique [DOI] 10.3389/fonc.2020.01267 PMC 바로가기 [Article Type] Oncology
Estimating actual COVID-19 case numbers using cumulative death count-A method of measuring effectiveness of lockdown of non-essential activities: a South African case studyResearch Published on 2020-07-012022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, [키워드] added African Analysis Asymptomatic case estimate close monitoring COVID-19 COVID-19 case cumulative death dropped effective Effectiveness evaluate Fatality rate growth help identify IFR implementation Incubation period Infection Infection fatality rate Infection prevention lockdown mild case outbreak Prevent programming reduce reducing remained reported Result SARS CoV-2 SARS-CoV-2 infected individual screening strategy South South Africa Spread spread of COVID-19 statistical Support testing coverage the mean time lag Transmission Viral transmission virus Weekly [DOI] 10.11604/pamj.supp.2020.35.2.24612 PMC 바로가기 [Article Type] Research
Prevalence of Sars-Cov-2 Infection in Health Workers (HWs) and Diagnostic Test Performance: The Experience of a Teaching Hospital in Central ItalyArticle Published on 2020-06-192022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] acute respiratory distress age Blood carried coronavirus 2 COVID-19 cross-sectional demonstrated diagnosed Diagnosis diagnostic employment experience exposure to female General population Health Health authority health workers (HWs), screening high risk hospital Hospitalization IgG IgM IgM/IgG infection rate infections Italy mandatory median age Nasopharyngeal swab Negative predictive value NPV outcome patients PCR assay performed Pneumonia positive Positive predictive value PPV Prevalence reference standard reported required respiratory retrospective RNA RNA RT-PCR SARS-CoV-2 SARS-COV-2 infection screening strategy sensitivity serology specificity subject Symptoms syndrome Teaching Test tested the SARS-CoV-2 venous were assessed worker [DOI] 10.3390/ijerph17124417 PMC 바로가기 [Article Type] Article
Assessing risk factors for SARS-CoV-2 infection in patients presenting with symptoms in Shanghai, China: a multicentre, observational cohort studyObservational Study Published on 2020-06-012022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] 95% CI affected analysed Analysis Assessing China clinics confirmed cases contagious COVID-19 determine diagnosed disease effective enrolled excluded exposure fatigue Fever foundation Ground glass opacity hospital independent risk factor International less lung Lymphocyte count multicentre natural Observational cohort study Odds ratio outbreak Patient patients patients with COVID-19 presenting risk factor SARS-COV-2 infection Science screening strategy Shanghai Spread study period Symptom the disease was used were excluded White blood cell [DOI] 10.1016/S2589-7500(20)30109-6 PMC 바로가기 [Article Type] Observational Study
Screening for COVID-19: Patient factors predicting positive PCR testResearch Brief Published on 2020-05-192022-10-30 Journal: Infection Control and Hospital Epidemiology [Category] COVID-19, MERS, SARS, [키워드] Characteristics COVID-19 determine evaluated Factor pandemic positive positive PCR test Positive test Predictive predictor recent resources Screening screening strategy tested Travel [DOI] 10.1017/ice.2020.249 PMC 바로가기 [Article Type] Research Brief
Hybridization Chain Reactions Targeting the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)Communication Published on 2020-05-012022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Algorithm base pairs cDNA chain complementary complex coronavirus 2 demonstrated DNA domain Efficiency Evidence facilitate gel electrophoresis help hybridization Hybridization chain reaction IMPROVE isothermal amplification Local loci molecular nucleocapsid Pandemics parameter PCR polymerase chain reaction Reactions respiratory RNase P SARS-CoV-2 SARS–CoV-2 screening strategy secondary structure sequence targeting [DOI] 10.3390/ijms21093216 PMC 바로가기 [Article Type] Communication
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors Research Published on 2020-04-092022-10-05 Journal: Nature [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome antiviral activity approved drugs assays clinical trial Clinical use Combination complex Compound computer-aided drug design coronavirus coronavirus disease disease drug drug candidate drug design Drug screening drug target Ebselen effective Efficacy enzyme exhibited half-maximal inhibitory concentration Infectious disease inhibited inhibitor MPro New coronavirus outbreak protease ranged responsible SARS-CoV-2 screening strategy Structure therapeutic agent these compound Transcription Treatment Vaccine Viral pneumonia viral replication [DOI] 10.1038/s41586-020-2223-y [Article Type] Research
Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious DiseasesResearch Article Published on 2015-12-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] alleles Analysis B-cell B-cell epitope candidate Cellular immune response Coverage CTL CTL epitope CTL epitopes cytotoxic T lymphocyte Diseases dominant effective elicit epitope helper T-cell epitope helper T-cell epitopes HLA binding Immune Epitope Database Immunity immunogen induce Infectious disease linear majority mapped MERS MERS-CoV Middle East neutralizing antibody nucleocapsid pandemic pathogen peptide Population Protective protective neutralizing antibody Protein provide public health Region respiratory syndrome coronavirus screened Screening screening strategy selected sequence T-cell T-cell Response target the N protein Vaccine vaccine candidates Vaccine development was performed [DOI] 10.1371/journal.pone.0144475 PMC 바로가기 [Article Type] Research Article