serine 2
[용어속성] Enzyme
SARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal Tubules
Cell and Developmental Biology
[키워드] ACE2
acute respiratory syndrome
addition
AKI
Angiotensin-converting enzyme
Autopsy
Blood urea nitrogen
cause
causes
cell type
cells
cohort analysis
Complication
coronavirus
coronavirus disease
Course
COVID-19
COVID-19 patients
demonstrated
disease stage
distal
expressed
Hospitalized
human kidney
kidney
Kidney injury
marker
occurred
outcome
patients
patients with COVID-19
poor prognosis
positive
prevalent
protease
protein level
proximal tubular cells
renal
renal tubular cells
Risk factors
RNAscope
SARS-CoV-2
SARS-COV-2 infection
serine 2
significantly
significantly higher
spike
the SARS-CoV-2
TMPRSS2
transmembrane
tubular cell
Tubule
[DOI] 10.3389/fcell.2021.664868 PMC 바로가기 [Article Type] Cell and Developmental Biology
[DOI] 10.3389/fcell.2021.664868 PMC 바로가기 [Article Type] Cell and Developmental Biology
Role of host factors in SARS-CoV-2 entry
SARS-CoV-2 진입에서 숙주 요인의 역할
Review
[키워드] ACE2
ACE2, angiotensin converting enzyme 2
addition
addressed
angiotensin
Angiotensin-converting enzyme
angiotensin-converting enzyme 2
Antigen
binding
C-type lectins
Cat B/L, cathepsin B/L
cathepsin
cathepsin B
Cathepsins
CD147
CD147, cluster of differentiation 147
Cell
cofactor
cofactors
complex
coronavirus
Cyp A/B, cyclophilin A/B
determine
disrupt
endocytosis
ENhance
entry cofactor
examined
Factor
Factors
feature
HCoV, human coronavirus
heparan sulfate
highlighting
highly pathogenic
Host
host cell
host cell membrane
host protease
host proteases
HSPG, heparin sulfate proteoglycan
human coronaviruses
human population
identify
IFITM, interferon-induced transmembrane proteins
interferon
ISG, Interferon-stimulated gene
locus
Ly6E, lymphocyte antigen 6E
lymphocyte
mechanism
membrane fusion
MERS-CoV, Middle East respiratory syndrome coronavirus
MHV, mouse hepatitis virus
neuropilin
Neuropilin-1
NRP-1, neuropilin-1
pathogenicity
Phosphatidylserine
plasma membrane
protease
proteoglycans
PS, phosphatidylserine
RBD, receptor binding domain
recent
receptor
receptors
RNA virus
role
SARS-CoV-2
SARS-CoV-2 entry
SARS-CoV-2 pandemic
SARS-CoV-2 receptor
SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
SARS-CoV, severe acute respiratory syndrome coronavirus
Serine
serine 2
sialic acids
Spike protein
sulfate
the cell
the SARS-CoV-2
TIM-1, T-cell immunoglobulin and mucin domain 1
TMPRSS2
TMPRSS2, transmembrane protease, serine 2
transmembrane
transmembrane protease serine 2
transmembrane protein
unique
Viral
viral envelope
viral spike protein
virus entry
virus receptor
zoonotic transmission
[DOI] 10.1016/j.jbc.2021.100847 PMC 바로가기 [Article Type] Review
[DOI] 10.1016/j.jbc.2021.100847 PMC 바로가기 [Article Type] Review
Platycodin D, a natural component of Platycodon grandiflorum , prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion
Platycodon grandiflorum의 천연 성분인 Platycodin D는 막 융합을 방해하여 리소좀 및 TMPRSS2에 의한 SARS-CoV-2 감염을 모두 예방합니다.
Article
[키워드] appear
Asia
basic
Basic science
block
Cell
cellular
cholesterol
Compound
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
cultured cells
direct fusion
displaying
disrupting
distribution
East
entry of SARS-CoV-2
gene silencing
global public health
herbal medicine
herbal medicines
Host
human cell
infection routes
inhibit
inhibit SARS-CoV-2
inhibitory effect
Inhibitory effects
internalization
Justin
Korean
Lipid signalling
Local
local foods
lysosomal
lysosome
Lysosomes
mechanism
membrane
membrane fusion
molecule
mutated
NPC
NPC1
organelle
pandemic
Patient
pharmacological
plant
plasma membrane
Platycodon
Prevent
protease
remedy
researcher
respiratory
Respiratory disease
responsible
Saponin
SARS-CoV-2
SARS-COV-2 infection
Science
Serine
serine 2
South
the cell
therapeutic strategy
TMPRSS2
transmembrane
transmembrane protease serine 2
treated
treating COVID-19
Treatment
viral infection
[DOI] 10.1038/s12276-021-00624-9 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s12276-021-00624-9 PMC 바로가기 [Article Type] Article
Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients
Article
[키워드] absence
ACE2
ACE2 expression
acute respiratory syndrome
addition
affected
affecting
age
angiotensin-converting enzyme 2
association
Biomarker
Biomarkers
BMI
body mass index
circulating
circulation
collected
Comorbidities
complications
coronavirus
coronavirus disease
correlated
COVID-19
Demographic factors
detectable
Diabetic
diabetic patients
ELISA
enzyme-linked immunosorbent
Epigenetic
Factor
Factors
Gender
groups
healthy controls
host receptor
in silico analysis
include
Infection
lung
microRNA
miRNA
miRNAs
multiple organ failure
non-coding RNA
Non-invasive
obesity
other organs
pandemic
Patient
patients
protease
quantified
quantitative PCR
reveal
reverse transcription
RNA
RT-qPCR
sACE2
SARS-CoV-2
serine 2
serum
Serum level
serum sample
soluble ACE2
TaqMan
TMPRSS2
transmembrane
Type
type 2 diabete
Type 2 diabetes mellitus
upstream
viral entry
was performed
with COVID-19
[DOI] 10.3390/ijms22105263 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/ijms22105263 PMC 바로가기 [Article Type] Article
Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients
COVID-19 환자에서 TMPRSS2 p.Val160Met 유전자 변이에 대한 초기 연구
Primary Research
[키워드] Affect
analysed
association
asymptomatic infection
C allele
cause
Cell
clinical manifestation
coronavirus disease
Coronavirus disease 2019
correlation
COVID-19
COVID-19 patient
COVID-19 severity
Ct value
death
diagnostic
disease
disease severity
field
field hospital
General Hospital
genetic variability
Genetic variant
genotyped
Health
health problem
hospitalised
Host
host cell
host cells
Indonesia
Infection
Interaction
Invasion
investigated
involved
mortality rate
nucleic acid
nucleic acid amplification
observé
outcome
Patient
patients with COVID-19
polymorphism
protease
Receptor binding
receptor complex
Result
SARS-CoV-2
SARS-CoV-2 viral load
SARS-CoV-2 virus
Serine
serine 2
severe COVID-19
severe pneumonia
severity
supplementary material
systemic inflammatory
TaqMan
the disease
the SARS-CoV-2
thought
TMPRSS2
transmembrane
transmembrane protease serine 2
Viral
Viral load
virus infection
[DOI] 10.1186/s40246-021-00330-7 PMC 바로가기 [Article Type] Primary Research
[DOI] 10.1186/s40246-021-00330-7 PMC 바로가기 [Article Type] Primary Research
A Cytopathic Effect-Based Tissue Culture Method for HCoV-OC43 Titration Using TMPRSS2-Expressing VeroE6 Cells
Research Article
[키워드] 50% tissue culture infectious dose assay
Accuracy
antibody
Cell
cell entry
cell lines
cells
complex
contribute
coronavirus
costly
CPE
Culture
culture supernatant
Cytopathic effect
early stage
expressing
HCoV-OC43
Human
human coronavirus
immunoperoxidase
indicated
infected cell
Infection
infectious dose
IPA
observation
protease
provide
Research
serine 2
staining
substrates
TCID
time-consuming
tissue
titration
TMPRSS2
transmembrane
VeroE6 cell
viral kinetics
viral titer
virus
[DOI] 10.1128/mSphere.00159-21 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mSphere.00159-21 PMC 바로가기 [Article Type] Research Article
Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells
플루티카손 프로피오네이트는 1차 인간 비강 상피 세포에서 폴리(I:C) 유도 ACE2를 억제합니다
Cellular and Infection Microbiology
[키워드] ACE2
ACE2 expression
ACE2 protein
Activation
Affect
affected
agonist
analyses
angiotensin
Angiotensin-converting enzyme
angiotensin-converting enzyme 2
cell entry
collected
Corticosteroid
COVID-19
dissemination
enzyme
epithelial cells
evaluate
examined
expression
expression of gene
fluticasone
fluticasone propionate
Fold change
followed by
Gene Expression
Health
health problem
HNECs
host cells
Human
immunoblot
immunofluorescence
incubated
Incubation
individuals
Infection
initial
innate immune
interferon
intranasal
intranasal steroid spray
investigated
mRNA expression
nasal
Nasal cavity
nasal epithelial cell
nasal mucosa
NFκB
objective
poly(I:C
poly(I:C)
promote
propionate
protease
Protein
quantitative PCR
receptor
regulated
required
reservoir
Result
SARS-CoV-2
SARS-CoV-2 cell
SARS-COV-2 infection
SARS-CoV-2 infections
SARS-CoV-2 viral
SARS-CoV2
Serine
serine 2
significantly increased
Spread
steroid
suppresse
suppressed
thought
TLR
TLR agonists
TLR3
TMPRSS2
Toll-like receptors
transmembrane
transmembrane protease serine 2
Viral
virus infection
[DOI] 10.3389/fcimb.2021.655666 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
[DOI] 10.3389/fcimb.2021.655666 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.
Research article
[키워드] 30-Day mortality
7-point ordinal scale
95% confidence interval
acute respiratory syndrome
Admission
adverse event
assigned
baseline
camostat mesilate
cell entry
Clinical improvement
conducted
coronavirus
coronavirus disease
discharge
double-blind
EudraCT
evaluated
finding
Frequency
hazard ratio
Hospitalization
ICU admission
in viral
Infection
interquartile range
investigator-initiated
IQR
Mortality
Multicenter trial
not affect
Oropharyngeal
Other outcome
participant
Patient
patients hospitalized
Placebo
placebo-controlled
Primary outcome
progression
protease
protocol
Randomized
Randomized controlled trial
randomized trials
Randomly
receive
SARS-CoV-2
SARS-COV-2 infection
serine 2
the placebo group
TMPRSS2
TMPRSS2 inhibitor
Treatment
two groups
Viral load
[DOI] 10.1016/j.eclinm.2021.100849 [Article Type] Research article
[DOI] 10.1016/j.eclinm.2021.100849 [Article Type] Research article
L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection
Article
[키워드] ACE-2
ACE2
ACE2 mRNA
acute respiratory syndrome
angiotensin-converting enzyme 2
Calu-3
cleavage
coronavirus
COVID-19
dose-dependent inhibition
drug
epithelial cells
evaluated
exercise
expression levels
Factors
furin
Host
Human
human lung
Infection
Inflammation
L-carnitine
limit
Pandemics
priming
protease
responsible
rodent
S-protein
SARS-CoV-2
SARS-COV-2 infection
serine 2
significant decrease
Tartrate
tested
TMPRSS2
transmembrane
Treatment
treatment strategy
Trial
Vaccines
viral spike
[DOI] 10.3390/nu13041297 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/nu13041297 PMC 바로가기 [Article Type] Article