Comparison between five PCR techniques for the diagnosis of SARS-CoV-2SARS-CoV-2 진단을 위한 5가지 PCR 기술 비교Article Published on 2022-08-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] COVID19(2023년), SARS, 치료기술, [키워드] Becton Dickinson commercial kits concentrations Concordance determine Diagnosis diagnosis of SARS-CoV-2 diagnostic Dilution epidemiological FIVE Infection Negative predictive value negative sample NPV PCR pooling Positive predictive value positive sample PPV Predictive value real time Roche RT-PCR RT-PCR kit SARS-CoV-2 sensitivity serological Seven Specificities specificity were used [DOI] 10.37201/req/076.2020 PMC 바로가기 [Article Type] Article
From a recombinant key antigen to an accurate, affordable serological test: Lessons learnt from COVID-19 for future pandemicsResearch article Published on 2022-08-012022-10-05 Journal: Biochemical Engineering Journal [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] Analysis antibody Antigen antigen expression Blood collected COVID-19 COVID-19 antibody test cut-off detect Detection of antibodies elicited by infection or vaccination develop dried blood spot Dried blood spot for diagnostic testing ELISA ELISA test enzyme-linked immunosorbent Final finger pricking handling high accuracy immunization Infection lesson pandemic Pandemics pathogen platform Protein Purification of SARS-COV-2 spike protein Receiver operator characteristic Recombinant antigen production in mammalian cells ROC sensitivity serological serological test Serological test development specificity Spike protein Spread Surveillance symptoms onset vaccination venous was performed [DOI] 10.1016/j.bej.2022.108537 [Article Type] Research article
Results of a European-Wide External Quality Assessment (EQA) Scheme for Serological Detection of Anti-SARS-CoV-2 (CoVimm)-Pitfalls of Routine ApplicationAnti-SARS-CoV-2(CoVimm)의 혈청학적 검출을 위한 유럽 전역 외부 품질 평가(EQA) 계획의 결과-일상 적용의 함정Article Published on 2022-07-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] addition Analysis analytical methods analytical techniques anti-S anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody application assessment biospecimen clinically comparability COVID-19 detection differentiation EQA Europe External external quality assessment scheme external quality control harmonization heterogeneity IgG IgG antibodies IgG antibody immunoassays implication Interpretation introduced Laboratory lack measure new SARS-CoV-2 nucleocapsid pace participated proficiency testing Quality Quality assurance reliability reported Result routine routine care SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 virus serological Serological testing specific IgG antibodies Spike protein standard care Standardization test performance test results thresholds total antibody variety virus [DOI] 10.3390/v14081662 PMC 바로가기 [Article Type] Article
The anti-SARS-CoV-2 monoclonal antibody bamlanivimab minimally affects the endogenous immune response to COVID-19 vaccination항SARS-CoV-2 단일클론항체 밤라니비맙은 코로나19 백신에 대한 내인성 면역 반응에 최소한의 영향을 미친다Randomized Controlled Trial Published on 2022-07-272022-09-12 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료제, [키워드] acute respiratory syndrome Affect age Analysis anti-SARS-CoV-2 Antibody Response benefit clinical trial collected coronavirus coronavirus disease Course COVID-19 COVID-19 mRNA vaccines COVID-19 vaccination dose enrolled evaluated immune response Infection magnitude Moderna monoclonal antibody mounted over pandemic participant Placebo placebo recipient Prophylactic public health Randomized receiving Risk category robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein serological serum sample subset Treatment Trial vaccination Vaccine were assessed [DOI] 10.1126/scitranslmed.abn3041 PMC 바로가기 [Article Type] Randomized Controlled Trial
Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응Article Published on 2022-07-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood [DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article
Post-vaccination antibody evaluation for nosocomial SARS-CoV-2 delta variant breakthrough infection병원 내 SARS-CoV-2 델타 변이형 돌발성 감염에 대한 백신 접종 후 항체 평가Observational Study Published on 2022-07-252022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-S IgG Anti-spike anti-spike antibody antibody Asymptomatic B.1.617.2 BNT162b2 booster vaccination Breakthrough infection Care Casirivimab characterized collected coronavirus Course Delta variants diagnosed Diagnosis eight estimation geometric mean geometric mean titer GMT hospital Humoral immunity IgG Imdevimab Infection Inpatient LAMP Loop-mediated isothermal amplification lowest measurement Mild mild to moderate mild to moderate severity moderate monoclonal antibody mRNA vaccination nosocomial observational study outbreak public health quantified RBD protein remained respiratory retrospective risk RT-PCR SARS-CoV-2 SARS-CoV-2 delta SARS-COV-2 infection SARS-CoV-2 vaccination Sequencing serological serum sample serum samples Seven severe acute respiratory syndrome Coronavirus severity therapy Treatment uninfected vaccination variant virus viruses was done whole-genome sequencing [DOI] 10.1371/journal.pone.0272056 PMC 바로가기 [Article Type] Observational Study
The Negative Impact of COVID-19 in HCV, HIV, and HPV Surveillance Programs During the Different Pandemic Waves다양한 유행병 동안 HCV, HIV 및 HPV 감시 프로그램에서 COVID-19의 부정적인 영향Article Published on 2022-07-222022-09-11 Journal: Frontiers in Public Health [Category] MERS, 진단, 치료기술, [키워드] analyzed chronic viral infections collapse coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic decrease decrease in HCV/HIV detection description detect diagnose Diagnosis elapsed Epidemic epidemic waves epidemiological expected First wave Follow-up HCV health system health systems hepatitis C hepatitis C virus highest HIV HIV infection HPV Human immunodeficiency virus human papillomavirus immunodeficiency virus Impact impact of COVID-19 Increases Infection infections lost infections. marker molecular negative New new infections number of sample number of samples pandemic papillomavirus patients Pneumonia primary care priority Program remained restoration risk screening program serological status Stress stress test Surveillance these viruses Treatment Viral viral infection viral infections virus viruses was reduced Wave [DOI] 10.3389/fpubh.2022.880435 PMC 바로가기 [Article Type] Article
COVID-19 symptom severity predicts neutralizing antibody activity in a community-based serological studyCOVID-19 증상 중증도는 커뮤니티 기반 혈청 연구에서 중화 항체 활성을 예측합니다Article Published on 2022-07-182022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] analyzed association blood sample Blood samples Community-based cohort conducted COVID-19 symptom demonstrated detectable General population highlight IgG antibodies immune response individual Infection information less magnitude measure NAb activity nAb response NAbs Neutralizing antibodies neutralizing antibody populations positive positive relationship predict protective immunity provide Re-infection Research SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody serological Serological testing seropositive participant seropositive participants severity Symptom symptom severity vaccination Variation Virus neutralization [DOI] 10.1038/s41598-022-15791-6 PMC 바로가기 [Article Type] Article
Temporal trends and differences of SARS-CoV-2-specific antibody responses in symptomatic and asymptomatic subjects: a longitudinal study from Umbria in Italy증상이 있는 대상과 무증상 대상에서 SARS-CoV-2 특이 항체 반응의 시간적 경향과 차이점: 이탈리아 Umbria의 종단 연구Article Published on 2022-07-182022-09-11 Journal: BMJ Open [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] anti-S anti-S antibody antibody Antibody Response Antibody responses Antibody titre antibody titres Asymptomatic Clinical severity clinically Cohort correlation COVID-19 Decline Diagnosis discharged Dynamics eligible first visit Follow-up follow-up study group hospital Immunity immunology Infectious diseases Italy longitudinal overtime participant Participants PCR test persistence positive Protein recruited reduced Reinfection remained SARS-CoV-2 SARS-COV-2 infection serological Serological testing significant difference significantly higher Signs and symptoms spike Spike proteins subject subjects Symptom symptomatic symptomatic and asymptomatic Temporal the median three group three groups threshold titre titres Treatment two groups U/mL Variation Virology while without symptom [DOI] 10.1136/bmjopen-2021-056370 PMC 바로가기 [Article Type] Article
Seroprevalence and dynamics of anti-SARS-CoV-2 antibodies: a longitudinal study based on patients with underlying diseases in Wuhan항-SARS-CoV-2 항체의 혈청유병률 및 역학: 우한의 기저 질환 환자를 기반으로 한 종단 연구Article Published on 2022-07-152022-09-11 Journal: Respiratory Research [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] 95% CI All participant All participants anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody titer Assessing asymptomatic patient asymptomatic patients baseline Blood blood sample Blood samples change Community COVID-19 Diseases door effective family members feature Follow-up Government healthcare Households Humoral immunity IgA IgG IgG antibodies IgG antibody IgG titer IgG titers IgM immunoglobulins individual infected with SARS-CoV-2 list Local local government natural infection Neutralising Antibodies neutralising antibody Neutralizing antibody titer no significant difference nucleocapsid protein participant Participants Patient positive Prevention and control Protein provided questionnaire Randomly remained Research SARS-CoV-2 SARS-CoV-2 nucleocapsid selected serological Seroprevalence serum sample serum samples significantly Single natural infection symptomatic patient Symptomatic patients telephone tested titer total antibodies total antibody underlying disease underlying diseases venous venous blood was collected were assessed Wuhan [DOI] 10.1186/s12931-022-02096-5 PMC 바로가기 [Article Type] Article