Severe COVID-19 pneumonia – Page 7 – Communicable Diseases Research

Outcomes of treatment of severe COVID-19 pneumonia with tocilizumab: a report of two cases from Tunisia

Tocilizumab으로 심각한 Covid-19 폐렴의 치료 결과 : 튀니지의 두 가지 사례에 대한 보고서

Case Reports

Published on 2021-11-022022-09-01
Journal: The Pan African Medical Journal [Category] SARS, 진단,

Tocilizumab and remdesivir in hospitalized patients with severe COVID-19 pneumonia: a randomized clinical trial

중증 코로나19 폐렴으로 입원한 환자를 대상으로 한 토실리주맙과 렘데시비르: 무작위 임상시험

Randomized Controlled Trial

Published on 2021-11-012022-09-11
Journal: Intensive care medicine [Category] 임상, 진단, 치료제,

[키워드] 7-category ordinal scale 95% CI adverse event assigned benefit clinical status Combination Corticosteroid Corticosteroids COVID-19 COVID-19 pneumonia Cox proportional hazard defined demonstrated died double-blind enrolled evaluated greater hospital discharge hospitalized patient intravenously investigator median time Multicenter trial occurred Ordinal Scale other treatment other treatments oxygen Patient patients patients hospitalized Placebo placebo-controlled Pneumonia Primary outcome provide randomization Randomized randomized clinical trial Randomly receive Remdesivir Serious Adverse Events severe COVID-19 Severe COVID-19 pneumonia supplemental oxygen Tocilizumab Trial
[DOI] 10.1007/s00134-021-06507-x PMC 바로가기 [Article Type] Randomized Controlled Trial

Clostridioides difficile and Vancomycin-Resistant Enterococci in COVID-19 Patients with Severe Pneumonia

Article

Published on 2021-10-222022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

Reviews

Published on 2021-10-182022-10-05
Journal: Cell Death and Differentiation [Category] 바이오마커, 신약개발, 임상, 치료제,

[키워드] Activation age Cancer cardiovascular diseases cascade cells characteristic complications COVID-19 COVID-19 cases deficiency described develop diabetes drug dysregulated Effect exacerbate Glutamine group groups High-risk patients human immunity hyperinflammation hypertension immune response include Infection lung metabolism metabolomics NAD+ NET Neutrophil extracellular traps obesity overproduced Pathologies pathophysiology pathway Patient predisposition Prevent profile Proinflammatory cytokine promote reduced regulatory T cells risk SARS-COV-2 infection SARS-CoV-2 vaccination severe COVID-19 severe COVID-19 patient Severe COVID-19 pneumonia STAT3 suggested suppressed the disease Treg while
[DOI] 10.1038/s41418-021-00892-y [Article Type] Reviews

X-linked recessive TLR7 deficiency in 1% of men under 60 years with life-threatening COVID-19

Observational Study

Published on 2021-10-082022-10-04
Journal: Science Immunology [Category] Fulltext, MERS, 변종, 임상, 진단,

Acute Limb Ischemia in a Patient With COVID-19 Pneumonia

Cardiac/Thoracic/Vascular Surgery

Published on 2021-10-072022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acute respiratory syndrome affected caused Comorbidities Complication complications coronavirus COVID-19 determinant elevated hypercoagulable illness inflammatory markers Ischemia limb limb ischemia Lower respiratory tract male occur Pneumonia presenting required SARS-CoV-2 Severe COVID-19 pneumonia severe disease significantly subsequent Thromboembolism venous worsening
[DOI] 10.7759/cureus.18574 PMC 바로가기 [Article Type] Cardiac/Thoracic/Vascular Surgery

Upregulation of Human Endogenous Retroviruses in Bronchoalveolar Lavage Fluid of COVID-19 Patients

COVID-19 환자의 기관지폐포 세척액에서 인간 내인성 레트로바이러스의 상향 조절

Research Article

Published on 2021-10-062022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] activated addition age analyzed BALF bronchial cell bronchial cells bronchial epithelial cell Bronchoalveolar lavage fluid Cancer cellular senescence changes in characterized China conditions controls Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity Disease progression disease severity dysregulated dysregulation element endogenous endogenous retroviruses epithelial cells examined explain exploration expression Families global pandemic groups HBEC HBECs healthy control healthy controls HERV HERVs Human human bronchial epithelial cells human endogenous retrovirus human endogenous retroviruses identify immune senescence increase in increasing age Infection Inflammation Inflammatory inflammatory pathway Inflammatory response Inflammatory responses Intensive lavage Local lung Lungs mechanism monocyte Monocytes Mortality Older age oncogene outcomes pathophysiological Patient PBMC PBMCs Peripheral blood peripheral blood monocytes Pneumonia populations Potential biomarker potential biomarkers potential therapeutic target provide recognize retroviral retrovirus risk factor SARS-CoV-2 senescent severe COVID-19 Severe COVID-19 pneumonia shown Transcriptome transcriptomes upregulated upregulation
[DOI] 10.1128/Spectrum.01260-21 PMC 바로가기 [Article Type] Research Article

Challenges in Steroid and Anticoagulant Therapy in Severe COVID-19 Pneumonia: A Prospective Study

Article

Published on 2021-10-062022-10-27
Journal: Antibiotics [Category] COVID-19,

[키워드] acute kidney adopted Anti-inflammatory Anticoagulant assessment Assiut University Hospital bleeding C reactive protein challenge Clinical outcome comorbid diseases Complication conducted Corticosteroid Corticosteroids COVID-19 COVID-19 patient D-dimer discharge disease enoxaparin ferritin flexible Follow-up group hematoma highest hospital Hospital stay ICU In-hospital lowest Lung fibrosis Methylprednisolone mortality rate multivariable Myocardial infarction outcome Oxygen therapy Patient patient group patients predictor Prospective protocol RT-PCR severe COVID-19 patient Severe COVID-19 pneumonia severe pneumonia significant difference standard treatment steroid Study design therapeutic therapy three group Treatment Treatment protocol two groups was performed
[DOI] 10.3390/antibiotics10101214 PMC 바로가기 [Article Type] Article

Post-COVID-19 pulmonary fibrosis and its predictive factors: a prospective study

Research

Published on 2021-10-052022-10-31
Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19,

[키워드] abnormality addition Admission age calculated changes changes in Chest CT chest CT scan Clinical severity Computed tomography consolidation Coronavirus disease 2019 COVID-19 COVID-19 patient cross-sectional CSS CT scan discharged Evidence Factors female Follow-up higher risk hospital increased risk Infection initial Inpatient Iran lung Lung fibrosis male moderate Odds ratio Patient Pneumonia Predictive Prospective Study pulmonary fibrosis recruited Result SARS-CoV-2 secondary outcome Severe COVID-19 pneumonia severe disease severity survived Survivors the patient treated was performed World Health Organization
[DOI] 10.1186/s43055-021-00632-9 PMC 바로가기 [Article Type] Research

Association of Serum Ferritin Levels and Methylprednisolone Treatment With Outcomes in Nonintubated Patients With Severe COVID-19 Pneumonia

삽관하지 않은 중증 코로나19 폐렴 환자에서 혈청 페리틴 수치와 메틸프레드니솔론 치료의 결과와의 연관성

Research

Published on 2021-10-042022-09-25
Journal: JAMA Network Open [Category] MERS, SARS, 바이오마커, 진단,

[키워드] 95% CI acute phase Administered Admission age Analysis analyzed Asian association baseline benefit Biomarker Black patient Clinical outcome cohort study Composite Corticosteroid COVID-19 daily dose death Effectiveness end point exposure ferritin ferritin level finding fraction functions high-flow oxygen therapy Importance Inflammation Laboratory Level lower mortality marker measure mechanical ventilation median Methylprednisolone Mortality New York objective outcome oxidative stress oxygen participant Patient Point Primary outcome Probability Protein receiving reduced Relevance reported Result retrospective cohort study secondary outcome Serum ferritin serum ferritin level setting severe COVID-19 Severe COVID-19 pneumonia systemic Treatment Treatment outcome treatment with methylprednisolone variables White patient
[DOI] 10.1001/jamanetworkopen.2021.27172 PMC 바로가기 [Article Type] Research