Signal transduction – Page 7 – Communicable Diseases Research

Cytoskeleton—a crucial key in host cell for coronavirus infection

Reviews

Published on 2020-12-272022-10-30
Journal: Journal of Molecular Cell Biology [Category] COVID-19,

Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue

안지오텐신 전환 효소 2 및 레닌-안지오텐신 시스템 수용체의 기능적 복합체: 태아 폐 조직이 아닌 성인에서의 발현

Article

Published on 2020-12-162022-09-12
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단,

[키워드] ACE2 activate acute respiratory syndrome alteration analogy angiotensin Angiotensin II angiotensin receptor Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding CAMP CD26 Cell cell entry chemokine Chemokine receptor cleave complexes component Coronaviruses COVID-19 CXCL12 CXCR4 dipeptidyl peptidase Dipeptidyl peptidase-4 downregulation energy transfer enzyme expression fetal G-protein highlight Human human ACE2 Human immunodeficiency virus immunodeficiency virus infect interact Interaction Ligand lung lung tissue Lungs macromolecular Mas receptor MAS1 mechanism membrane mitogen-activated protein kinase organs performed potential therapeutic targets Protein protein kinase RAS receptor receptors Renin renin-angiotensin system respiratory SARS-COV-2 infection SARS-CoV-2 receptor SDF-1 Severe acute respiratory syndrome Signal transduction Signaling System target cell target cells upregulation while
[DOI] 10.3390/ijms21249602 PMC 바로가기 [Article Type] Article

Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection

SARS-CoV-2 감염과 관련된 신호 전달 회로의 기계 학습 및 기계 모델을 사용하여 COVID-19에 대한 약물 용도 변경

Letter

Published on 2020-12-112022-08-31
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 신약개발, 진단, 치료제,

[키워드] COVID-19 Drug repurposing Infectious diseases Predictive medicine SARS-COV-2 infection Signal transduction Target identification
[DOI] 10.1038/s41392-020-00417-y PMC 바로가기 [Article Type] Letter

Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic

Case Report

Published on 2020-12-042022-11-01
Journal: Dermatopathology [Category] COVID-19,

An in silico LLPS perturbation approach in the design of a novel SARS-CoV-2 spike receptor-binding domain inhibitor

Correspondence

Published on 2020-11-252022-11-01
Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19,

[키워드] approach biological processe biological systems chromatin domain homogenous in silico include inhibitor membrane envelope metabolism Nucleolus organelle Regulation resulting RNA SARS-CoV-2 spike shown Signal transduction stress granules
[DOI] 10.1186/s43042-020-00105-0 PMC 바로가기 [Article Type] Correspondence

Defensive Properties of Mucin Glycoproteins during Respiratory Infections—Relevance for SARS-CoV-2

Minireview

Published on 2020-11-122022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] activate acute respiratory syndrome adhesin age airway Bacterial boost clearance component Contact coronavirus Defense dependent on downregulation efficient clearance example expressed expression facilitate Factor female glycan glycans glycoprotein glycosylation Inflammatory inflammatory state Interaction Invasion ligands microbe microbial microbial infections Motile cilia MUC1 MUC16 MUC4 MUC5AC MUC5B mucin mucin-microbe interactions mucins mucosal mucosal barrier Mucus Novel coronavirus O -glycosylated O-linked glycans pathogen Pathways Prevent Proinflammatory cytokine property receptors regulated respiratory respiratory infections Respiratory pathogens respiratory tract SARS-CoV-2 sex hormone estradiol Signal transduction the healthy therapy transmembrane understanding upregulated viral infection virulence
[DOI] 10.1128/mBio.02374-20 PMC 바로가기 [Article Type] Minireview

Clinical Trial to Evaluate an Approved ITP Therapy Targeting Spleen Tyrosine Kinase (SYK) for Prevention and Treatment of COVID-19 Related Complications

Conference abstract

Published on 2020-11-042022-10-05
Journal: Blood [Category] 임상,

[키워드] Activation Acute kidney injury acute lung injury acute respiratory distress AKI allergic ARDS Autoimmune capillary leak syndrome caused clinical clinical status clinical study CLR Complication complications COVID-19 COVID-19 patient COVID-19 patients current Cytokine storm Diseases disorders double-blind download downstream Efficacy and safety Endothelial cell equity evaluate evaluated Fc receptor figure fostamatinib Hospitalized hospitalized COVID-19 patients Hyperactivation immune complex immune system immune systems Immune thrombocytopenia immunomodulatory effect implicated improvement incidence inhibitor involved kidney kinase LPS lung master regulator metabolite monocyte mouse model Nadeem neutrophil other treatment pathogen pathway Patient patients patients treated phase placebo-controlled plasma Platelets Prevent prevention Progress Protective Randomized receptor reduced reference Result rheumatoid arthritis risk safety profile Signal transduction Standard of care SYK syndrome target targeting the cytokine storm therapeutic strategy Thromboembolic event Thromboembolic events thrombosis tissue damage treated Treatment Van
[DOI] 10.1182/blood-2020-141045 [Article Type] Conference abstract

DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines

박테리아의 DNA 슈퍼코일링 차이는 폴리아민에 의한 이질적인 DNA 자이라제 활성화로 인해 발생합니다.

Research Article

Published on 2020-10-302022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated Activation activity addition Alter Amino acid Bacteria bacterial species bacterial specy change changes in Concentration conserved Control determine discrepancies discrepancy disparate DNA DNA supercoiling E . coli enzyme Enzymes Escherichia coli Extracellular gyrase humans identify identity in vivo inhibit living cell mechanism metabolic conditions metabolic pathway metabolic pathways organism pathogen Pathogens pathway physiological polyamine polyamines precursor putrescine reducing reflect regulate regulated responsible Salmonella Signal transduction spermidine target topoisomerase
[DOI] 10.1371/journal.pgen.1009085 PMC 바로가기 [Article Type] Research Article

ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection

Original Paper

Published on 2020-10-262022-11-01
Journal: Epidemiology and Infection [Category] COVID-19, MERS, SARS,

Quantitative proteomic analysis of the tizoxanide effect in vero cells

Article

Published on 2020-09-072022-10-04
Journal: Scientific Reports [Category] 치료제,