Prevalence, Persistence, and Factors Associated with SARS-CoV-2 IgG Seropositivity in a Large Cohort of Healthcare Workers in a Tertiary Care University Hospital in Northern Italy이탈리아 북부의 3 차 간호 대학 병원에있는 의료 종사자들의 대규모 코호트에서 SARS-COV-2 IgG 혈청 양성과 관련된 유병률, 지속성 및 요인Observational Study Published on 2021-06-032022-09-01 Journal: Viruses [Category] MERS, 임상, 진단, [키워드] active smoker active smokers antibody Asymptomatic Care comparable Contact COVID COVID-19 COVID-19 serological testing Europe evaluate evaluated evidenced Factor Frequency Health care health care workers Health personnel highest hospital household increased risk individual Infection Italy multivariable analysis observational study occurred Odds ratio pandemic performed population surveillance positive Ratio reported risk SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection seropositive subject seropositive subjects Seropositivity Seroprevalence significant difference significant differences significantly Smokers subject surveys and questionnaires Symptom Tertiary tested Turin university worker [DOI] 10.3390/v13061064 PMC 바로가기 [Article Type] Observational Study
Persistently Increased Systemic ACE2 Activity Is Associated With an Increased Inflammatory Response in Smokers With COVID-19Physiology Published on 2021-05-282022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] ACE2 activity Affect analyzed angiotensin cardiopulmonary diseases changes in conducted controls CoV COVID-19 COVID-19 infection COVID-19 pathogenesis COVID-19 patient COVID-19 patients cytokine levels demonstrated determine enzymatic activity enzyme activity Eotaxin furin healthy healthy controls IL-9 Immunity increase in Increased Infection infectious agent Inflammation Inflammatory cytokine involved lipid mediator Lung injury MCP-1 Multiplex assay outcome Pathogenesis pathogenesis of COVID-19 Patient patients patients with COVID-19 peptide positive progression Proteins pulmonary disease response serum serum sample serum samples significantly significantly increased smoker Smokers smoking subject susceptible systemic systemic inflammatory marker systemic level Tobacco weakened [DOI] 10.3389/fphys.2021.653045 PMC 바로가기 [Article Type] Physiology
Cumulative annual coverage of meningococcal B vaccination in Australian general practice for three at-risk groups, 2014 to 2019Research Paper Published on 2021-05-282024-09-04 Journal: Human vaccines & immunotherapeutics [Category] 대상포진, [키워드] Adolescent General practice Immunocompromised host Meningococcal Smokers vaccination coverage [DOI] 10.1080/21645515.2021.1923349 PMC 바로가기 [Article Type] Research Paper
Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 PneumoniaCOVID-19 폐렴이 있는 흡연자의 폐 조직에서 안지오텐신 전환 효소 2 수용체의 낮은 유전자 발현Article Published on 2021-05-262022-09-01 Journal: Biomolecules [Category] SARS, 진단, [키워드] ACE-2 acute respiratory syndrome age angiotensin Angiotensin converting enzyme receptor Angiotensin-converting enzyme aspect Autopsies Bayesian biological interaction case sery cell entry receptor Chain Reaction complex concerning coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pneumonia Critical enzyme evaluated expression expressor focus Gender Gene Expression hypertension Infection less Lower lung lung tissue lung tissue sample lung tissue samples mRNA expression observational study polymerase chain polymerase chain reaction prevalent real-time polymerase chain reaction respiratory retrospective risk factor SARS-CoV-2 SARS-CoV-2 genome Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Severe COVID-19 pneumonia smoker Smokers smoking susceptibility susceptibility to infection translational Vascular injury Viral virus with COVID-19 [DOI] 10.3390/biom11060796 PMC 바로가기 [Article Type] Article
Association Between Smoking and SARS-CoV-2 Infection: Cross-sectional Study of the EPICOVID19 Internet-Based SurveyObservational Study Published on 2021-04-282022-10-04 Journal: JMIR Public Health and Surveillance [Category] MERS, 임상, [키워드] 95% CI ad hoc adjusted Administered affected age Analysis analyzed association Asymptomatic calculated Characteristics Chronic diseases confounders COVID-19 cross-sectional cross-sectional design current disease severity dose-dependent dose-response relationship female Hospitalized hospitalized COVID-19 individual Infection infection severity investigated Italian Italian population less Logistic mechanism Mild moderate multinomial regression Nasopharyngeal swab nasopharyngeal swab testing NPs objective Odds ratio positive Prevalence Probability questionnaire Registration reported Result SARS-CoV-2 SARS-COV-2 infection self-reported Severe infection severity significantly lower smoker Smokers smoking smoking habit smoking status Sociodemographic statistically survey Symptom tested Volunteer web-based survey [DOI] 10.2196/27091 PMC 바로가기 [Article Type] Observational Study
Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium대 기도 상피에서 COVID-19 관련 유전자의 발현에 영향을 미치는 유전 적 및 비 유전 적 요인Multicenter Study Published on 2021-04-212022-09-10 Journal: Genome Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 binding ACE2 expression ACE2 gene active smoking affecting airway airway epithelium analyzed association Asthma Bronchial epithelium cardiovascular disease cause change chronic obstructive chronic obstructive pulmonary disease clinically Cohort cohorts contribute COPD COVID-19 COVID-19 severity COVID-19 susceptibility Defense determine disease course driven by enrichment analysis environmental factor epithelial eQTL eQTL mapping Evidence expression expression pattern expression patterns Factor Factors Gene Expression Gene Set Enrichment Analyses Genetic genetic factors Genetic variant Genetic variation Host host response hypertension identify immune response implicated individuals Inflammation inter-individual interferon investigated involved isoform non-binding obesity obstructive pulmonary disease performed phenotypic provide pulmonary disease Quantitative Regulation Regulatory replicated respiratory respiratory infections respiratory viruses Result risk factor RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sequencing data smoker Smokers smoking subsequent supplementary material suppressed susceptibility the SARS-CoV-2 virus These data uninfected Variability variant variants Variation viruses [DOI] 10.1186/s13073-021-00866-2 PMC 바로가기 [Article Type] Multicenter Study
Can predicting COVID-19 mortality in a European cohort using only demographic and comorbidity data surpass age-based prediction: An externally validated studyResearch Article Published on 2021-04-152022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Accuracy Admission age applied AUC Belgium Bonferroni correction build Can Cancer chose chronic cardiac disease Chronic kidney disease chronic neurological disease chronic obstructive Clinical outcome Cohort collected Comorbidity COVID-19 COVID-19 mortality COVID-19 patient curated death Dementia demographics diabetes discharged distribution eight Electronic health record European external validation feature Features FIVE Gender hospital hypertension incidence Inpatient interquartile range IQR lockdown male median median age Mortality Netherlands nine objective outperform Patient precursor pulmonary disease Result selected Smokers statistically significant the mortality group Vaccine were used [DOI] 10.1371/journal.pone.0249920 PMC 바로가기 [Article Type] Research Article
Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells폐 상피 세포에서 E3 유비퀴틴 리가제 Skp2에 의한 SARS-CoV-2 수용체 ACE2의 분해Article Published on 2021-04-012022-09-12 Journal: Frontiers of medicine [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 mRNA ACE2 protein Adults Aryl hydrocarbon receptor benzo(a)pyrene Cancer carcinogen cells COVID-19 pandemic CSE death determine downregulate E3 ligase E3 ubiquitin ligase Hospitalized induce Infection inhibit SARS-CoV-2 lung epithelial cell lung tissue mice observation pseudovirion SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Skp2 smoker Smokers smoking Spike protein Tobacco tobacco smoke. upregulation urgent investigation [DOI] 10.1007/s11684-021-0837-6 PMC 바로가기 [Article Type] Article
Text Messaging Intervention for Young Smokers Experiencing Homelessness: Lessons Learned From a Randomized Controlled TrialOriginal Paper Published on 2021-04-012022-10-31 Journal: JMIR mHealth and uHealth [Category] COVID-19, MERS, SARS, [키워드] administer analyzed approach approval assigned automated baseline cessation resources changed component Controlled counseling COVID-19 epidemic develop effective element feasibility feasible Follow-up follow-up period General population help homeless Identifier implementation include indicated ineligible Interaction Intervention lesson Los Angele majority objective offer participant Peer support people experiencing homelessness platform Qualitative quitting Randomized controlled trial Randomly receive receiving recruited Registration report reported resource Result significantly higher Smartphone smoker Smokers smoking smoking rate study participation suggested Support text text messaging widespread young adults [DOI] 10.2196/23989 PMC 바로가기 [Article Type] Original Paper
Spatial and temporal trends in social vulnerability and COVID-19 incidence and death rates in the United StatesResearch Article Published on 2021-03-242022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] average Bayesian center Community conducted Control COVID-19 COVID-19 incidence COVID-19 outbreak Daily temperature death rate death rates Effect examined female Health Hierarchical higher risk index less longitudinal analysis pandemic physician prevention primary care proportion quartile quartiles Result reversed risk ratio RRs Smokers tested the United State USAFacts vulnerability [DOI] 10.1371/journal.pone.0248702 PMC 바로가기 [Article Type] Research Article