Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO studyObservational Study Published on 2021-03-012022-10-05 Journal: Diabetes & metabolism [Category] SARS, 임상, [키워드] Admission analyses Analysis approach association cardiovascular disease Characteristics COVID-19 COVID-19 related mortality death Diabetes Mellitus French high-risk population hospital increased mortality Inpatient Interaction intubation Logistic regression analysis Mortality mortality rate outcome outcomes Patient patients hospitalized patients with COVID-19 phenotypic Primary outcome Probability Prognosis recent reported Result routine severe coronavirus disease significantly significantly higher statins tracheal Treatment Type type 2 diabete Type 2 diabetes mellitus Weighting women [DOI] 10.1016/j.diabet.2020.10.001 PMC 바로가기 [Article Type] Observational Study
Familial hypercholesterolaemia and COVID-19: A two-hit scenario for endothelial dysfunction amenable to treatmentReview article Published on 2021-03-012022-10-05 Journal: Atherosclerosis [Category] 치료법, [키워드] acute phase benefit cardiac event cardiovascular complication COVID COVID-19 COVID-19 complication COVID-19 infection COVID-19 pandemic effective elevated Endothelial dysfunction Endothelium expected Familial hypercholesterolaemia Familial hypercholesterolemia heterozygous homozygous increased risk Infection infections LDL-C lipoprotein cholesterol mitigate occurred pandemic Patient patients patients with COVID-19 PCSK9 inhibitors reduction risk severe COVID-19 severity of COVID-19 statins subject therapy Treatment [DOI] 10.1016/j.atherosclerosis.2021.01.021 [Article Type] Review article
Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19Article Published on 2021-02-262022-10-04 Journal: Nature Communications [Category] MERS, 바이오마커, 임상, 치료법, [키워드] 1:1 95% CI acute respiratory distress antecedent Anti-inflammatory Antithrombotic ARDS baseline benefit Clinical characteristics Cohort coronavirus disease COVID-19 COVID-19 patients decreased mortality Effect hospitalized patient hyperinflammatory state in-hospital mortality include information medication medications Mortality multivariable logistic regression myocardial injury Patient patients hospitalized predict primary endpoint receiving Retrospective analysis SARS-CoV-2 significantly Sociodemographic statins study period syndrome the primary endpoint Thrombotic complications viral infection viral infections with COVID-19 [DOI] 10.1038/s41467-021-21553-1 PMC 바로가기 [Article Type] Article
Targeting Lipid Rafts as a Strategy Against CoronavirusCell and Developmental Biology Published on 2021-02-042022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor acute respiratory syndrome Affect affecting Against Alpha angiotensin-converting enzyme-2 Antiviral compounds approach autophagic bind binding Bioavailability characterized cholesterol clearance complexes component coronavirus Coronavirus-2 Coronaviruses cyclodextrins domain downstream drug functional host cell host cell membrane host cell surface impairing Inclusion involved Lipid Lipid rafts main receptor membrane N-terminal Necrosis pharmacological platform proinflammatory molecule raft reducing Region Remdesivir SARS-CoV-2 selective sialic acid sphingolipids Spike protein statins Strategy targeting the SARS-CoV-2 the spike protein these compound TNF-α viral envelope viral replication virus infectivity viruses [DOI] 10.3389/fcell.2020.618296 PMC 바로가기 [Article Type] Cell and Developmental Biology
Decreased Mortality Rate Among COVID-19 Patients Prescribed Statins: Data From Electronic Health Records in the USMedicine Published on 2021-02-032022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 addition angiotensin-converting enzyme 2 Anti-inflammatory clinical outcomes Comorbidities Control coronavirus disease COVID-19 COVID-19 infection COVID-19 patient decrease Decreased demographics diagnosed with COVID-19 Effect Electronic health records Evidence expression host response immunomodulatory property IMPROVE In-hospital increase in Inflammatory response medication Meta-analysis Mortality mortality rate nine outcome oxidative stress Patient patient population pro-inflammatory propensity score matching raised Randomized controlled trial Rate receptor Record reduced reduction reduction in mortality reflected reported responsible retrospective SARS-CoV-2 severe respiratory illness severity statins statistically significant Support the disease the SARS-CoV-2 virus the United State to define triggered virus with COVID-19 [DOI] 10.3389/fmed.2021.639804 PMC 바로가기 [Article Type] Medicine
Cholesterol, lipoproteins, and COVID-19: Basic concepts and clinical applicationsReview Published on 2021-02-012023-07-11 Journal: Biochimica et biophysica acta. Molecular and cell [Category] SARS, [키워드] cholesterol COVID-19 high density lipoprotein low density lipoprotein SARS-CoV-2 statins [DOI] 10.1016/j.bbalip.2020.158849 PMC 바로가기 [Article Type] Review
Statins in patients with COVID-19: a retrospective cohort study in Iranian COVID-19 patientsResearch Published on 2021-01-252022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] acute respiratory syndrome affected Antiviral effect approved association caused clinical symptom Computed tomography coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients death drug Effect effective vaccine evaluate exclusion criteria Infection initial involved Iran lower risk lung mechanical ventilation morbidity Mortality mortality rate pandemic Patient patients patients with COVID-19 patients with COVID19 Pleiotropic effects Prevent propensity score matching Randomized controlled trial recruitment reduce reduced reduction in mortality Regression model repurposing Result retrospective cohort study Retrospective study safety profile SARS-CoV-2 statin statins statistical significance treat Treatment triggered Vaccine were used with COVID-19 wound healing [DOI] 10.1186/s41231-021-00082-5 PMC 바로가기 [Article Type] Research
Statins as Adjuvant Therapy for COVID-19 to Calm the Stormy Immunothrombosis and BeyondPharmacology Published on 2021-01-192022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] adjuvant Atherosclerosis cardiovascular disease coronavirus COVID-19 COVID.19 immune response statin statins [DOI] 10.3389/fphar.2020.579548 PMC 바로가기 [Article Type] Pharmacology
Perspective Adjunctive Therapies for COVID-19: Beyond Antiviral TherapyReview Published on 2021-01-012022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, [키워드] anti-inflammatory activity approach Asymptomatic boost coronavirus disease COVID-19 COVID-19 infection demographic Deterioration Disease progression disease severity distribution drug effective Health healthy Immune cell Immunity immunomodulatory indomethacin Infection Infection prevention Inflammatory inflammatory reaction inherent intensive care Interaction medication Medicine melatonin Mild symptom organ pandemic pathophysiological pathway Prevent PROTECT provided reduce Region statins Support the disease therapeutic agent therapy traditional medicines Treatment vitamins and minerals [DOI] 10.7150/ijms.51935 PMC 바로가기 [Article Type] Review
Associations of Medications With Lower Odds of Typical COVID-19 Symptoms: Cross-Sectional Symptom Surveillance StudyClinical Trial Published on 2020-12-142022-10-04 Journal: JMIR Public Health and Surveillance [Category] MERS, SARS, 임상, [키워드] 95% CI age Analysis Antibody test antihypertensive therapy antihypertensives approved association Asymptomatic COVID-19 clinical combating conducted COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 symptom COVID-19 symptoms criteria effective employment evaluate the effect Gender Germany globe healthcare hydroxymethyl-glutaryl-coenzyme A reductase inhibitors identify illnesses increased risk individual investigated logistic regression models Lower management medication objective Odds ratio online survey participant participated polymerase chain positive RT-PCR protocol questionnaire ratio estimate Registration registry Result reverse transcription RT-PCR SARS-CoV-2 Side effect Spread statins statistically significant suggested Surveillance Symptom Symptoms symptoms of COVID-19 the disease therapy treat Treatment Typical vaccination World Health Organization [DOI] 10.2196/22521 PMC 바로가기 [Article Type] Clinical Trial