Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen testsArticle Published on 2022-09-152022-11-15 Journal: Cell [Category] SARS, 변종, 진단, 치료기술, [키워드] antibodies antibody Antibody binding Antigen Complete COVID-19 patient deep deep mutational scanning diagnostic Effect Emergency use authorization epitope epitope mapping escape mutation evaluate identify mammalian mammalian surface-display Mutation platform Point mutation predict profile public health rapid antigen test Rapid antigen tests Rapid diagnostic tests SARS-CoV-2 SARS-CoV-2 nucleocapsid protein susceptibility the antibody utility valuable resource variants variants of concern variants of SARS-CoV-2 [DOI] 10.1016/j.cell.2022.08.010 PMC 바로가기
SARS-CoV-2 can infect human embryosArticle Published on 2022-09-142022-11-15 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] ACE2 antibody canonical Cell cell entry cells co-expressed COVID-19 COVID-19 pandemic Effect Embryo embryogenesis embryos Factor fluorescent glycoprotein Health human tissue identify immunofluorescence implicated implication infect Infection observé organ pandemic Pregnancy reporter reproductive resulting RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection spike Spread susceptibility susceptible Symptom target tissue TMPRSS2 viral entry virions pseudotyped [DOI] 10.1038/s41598-022-18906-1 PMC 바로가기
Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2Article Published on 2022-09-142022-10-06 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Analysis antibodies BA.1 BA.2 BNT162b2 vaccine change COVID-19 COVID-19 pandemic D614G determinant domain driven by Evolution examined functional hinge region immune evasion Impact individual introduced MOST Mutation N-terminal neutralization omicron other variant pandemic Protein reduced SARS-CoV-2 SARS-CoV-2 variant sensitivity sera spike Spike protein susceptibility the Spike therapeutic thought Transmission variant variant evolution. [DOI] 10.1016/j.chom.2022.07.006 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patternsArticle Published on 2022-09-142022-10-06 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody antigenic BA.2.12.1 BA.4 BA.5 convalescent COVID-19 Critical effective strategy favor identify immune Immune escape inactive monoclonal antibody MOST Neutralizing Neutralizing antibodies neutralizing antibody omicron polyclonal predominant provide reduction in resistance SARS-CoV-2 sensitivity sera serum sublineages. susceptibility Treatment vaccinated individual vaccinee variants viral evolution [DOI] 10.1016/j.chom.2022.07.002 PMC 바로가기 [Article Type] Article
Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2Article Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome amino acid substitution amubarvimab (BRII-196) antibody antibody cocktail Clinical efficacy Combination controls coronavirus coronavirus disease COVID-19 demonstrated Emergency use authorization epitope EUA Evolution half-maximal inhibitory concentration half-maximal inhibitory concentration (IC50) in vitro introduced less Lung pathology Lungs M252Y/S254T/T256E (YTE) mAb mAbs Modification monoclonal antibody monoclonal antibody (mAb) Mutation neutralize neutralized Neutralizing Post-infection Preclinical RBD receiving Receptor binding domain receptor binding domain (RBD) reduce reduced regions regulatory authority resulting retained romlusevimab (BRII-198) SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly Spike protein Support susceptibility therapeutic option variant variant of concern (VOC) variants variants of concern Viral load virus VoC weight loss [DOI] 10.3389/fimmu.2022.980435 PMC 바로가기
The regulation of ISG20 expression on SARS-CoV-2 infection in cancer patients and healthy individualsArticle Published on 2022-09-132022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] analyzed anti-SARS-CoV-2 anticancer Bone marrow Cancer cancer cell cancer cell lines cancer patient Cancer patients chemokine combating cordycepin cordycepin (CD). correlated COVID-19 COVID-19 pandemic domain exhibited expression functional healthy healthy individual highest immune Immune cell infiltration immune infiltration individuals information inhibit Invasion ISG20 ISG20 expression isoform less Lymphocytes lymphoid tissues marker Methylation MHC molecule mRNA expression mutant N6 N6-dimethyladenosine (m 6 2A) outcome overexpression promoter receptors Regulation SARS-CoV-2 SARS-COV-2 infection significantly significantly increased significantly lower small molecule survival survival rate susceptibility the median therapeutic potential tissue tissues traditional Chinese medicines treat tumorigenesis underlie virus were used [DOI] 10.3389/fimmu.2022.958898 PMC 바로가기
SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeabilityArticle Published on 2022-09-132022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 addition Apoptosis CD147 Cell cell lines cells Coagulation complement Cytokine storm Effect elevated elicit endothelial event Evidence expression fetal Hyperactivation immunopathological Impact incidence increased vascular permeability induce infected with SARS-CoV-2 Infection Inflammation less main receptor mechanism modulate Mortality mother outcomes pathway Placenta placental positive Pregnancy pregnant Preterm birth pro-inflammatory cytokine Protein raise SARS-CoV-2 spike susceptibility syndrome the SARS-CoV-2 TMPRSS2 TMPRSS2 expression Transmission upregulated virus virus receptor [DOI] 10.3389/fimmu.2022.957224 PMC 바로가기
Susceptibility of Domestic Goat ( Capra aegagrus hircus) to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.351/Beta VariantArticle Published on 2022-09-092022-11-16 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome angiotensin-converting enzyme 2 Beta Beta variant classical coronavirus coronavirus 2 demonstrated distribution ELISA Evidence Experimental infection goat immunohistochemistry in silico Approach infect Infection Live virus nasal swab natural neutralisation assays performed predict reported respiratory RT-qPCR ruminant SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility susceptible the receptor-binding domain the spike protein tissue unlikely variant Viral variants was used wild animals [DOI] 10.3390/v14092002 PMC 바로가기
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19Article Published on 2022-09-082022-11-16 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Against Analysis approved bioinformatics caused Clinical characteristics Clinical data contagious coronavirus Coronavirus disease 2019 correlation country COVID-19 COX Cytoscape downloaded drug drug target DrugBank evaluate evaluated Fatality rate FDA Features food functional Gene Expression GeneCards Genes GO enrichment analysis IL-17 IL12B IL6 include infected with COVID-19 Interaction KEGG LBP lung adenocarcinoma (LUAD) lung cancer patient management mechanism modulate molecular molecular docking Mortality NCBI network network pharmacology pandemic pathway Pathway analysis Patient Paxlovid Pharmacology Potential potential therapeutic target Prognosis prognostic receptor Regression model risk SARS-CoV-2 screened signaling pathway survival rate susceptibility SwissTargetPrediction target target gene TargetNet therapeutic target Transcriptome Treatment Venn diagram virus was performed was used while [DOI] 10.3389/fendo.2022.935906 PMC 바로가기
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 modelArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] Activation animal model antiviral property ciliated cells COVID-19 disease epithelial Factor FG-4592 Host hypoxia hypoxic identify increased expression Infection Infectious virus inhibit SARS-CoV-2 inhibitor intrinsic Lower respiratory tract lung epithelia microenvironment nucleocapsid expression pathological analysis pathway provide reduced reduction in regulate respiratory pathogen respiratory symptom SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA significantly susceptibility therapeutic Therapies transcriptional treated understanding virus replication [DOI] 10.1371/journal.ppat.1010807 PMC 바로가기