A Rolling Circle-Amplified G-Quadruplex/Hemin DNAzyme for Chemiluminescence Immunoassay of the SARS-CoV-2 ProteinSARS-CoV-2 단백질의 화학발광 면역분석을 위한 롤링 서클 증폭 G-사중체/헤민 DNA자임Article Published on 2021-07-202022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료제, [키워드] Accuracy Analysis applicability chemiluminescence complex Concentration Conjugates coronavirus epidemic demonstrated detectable Detection limit Diagnosis DNA DNA sequence hemin hydrogen hydrogen peroxide intrinsic luminol magnitude Oxidation pair primer produced Protein released Research Rolling Rolling circle amplification SARS-CoV-2 protein sensitive serum sample serum samples target protein the SARS-CoV-2 triggered [DOI] 10.1021/acs.analchem.1c02229 PMC 바로가기 [Article Type] Article
Pinpointing the potential hits for hindering interaction of SARS-CoV-2 S-protein with ACE2 from the pool of antiviral phytochemicals utilizing molecular docking and molecular dynamics (MD) simulations분자 도킹 및 분자 역학(MD) 시뮬레이션을 활용하여 항바이러스 식물 화학 물질 풀에서 SARS-CoV-2 S-단백질과 ACE2의 상호 작용을 방해할 수 있는 잠재적 히트를 정확히 찾아냅니다.Article Published on 2021-06-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] SARS, 치료제, [키워드] ACE2 Allium alveolar analyzed angiotensin Antidote Antiviral Antiviral phytochemicals Asparagus Bundle cell entry coronavirus disease COVID-19 Curcuma disease disease outbreak domain Dynamics enzyme feature FIVE free energy Free energy calculation human cell Infection interact Interaction interactions lead membrane molecular molecular docking molecular dynamics molecular dynamics (MD) simulation molecules Novel coronavirus outbreak performed pharmacophore plant portion profile proposition Protein racemosus RBD Receptor-binding domain recognize Research responsible S-protein S-Protein blocker SARS-CoV-2 SARS-CoV-2 novel coronavirus. spike target protein these compound these compounds triggering Vaccine viral membrane viral particle were used [DOI] 10.1016/j.jmgm.2021.107874 PMC 바로가기 [Article Type] Article
The current landscape of nucleic acid therapeutics Reviews Published on 2021-05-312022-10-05 Journal: Nature nanotechnology [Category] 변종, 유전자 메커니즘, [키워드] addition adeno-associated virus Antisense oligonucleotides approaches approved causes clinically Conjugates Conventional curative disease drugs Effect example explain facilitate facilitated Genetic highlight IMPROVE in vivo induce Lipid nanoparticle long-lasting Messenger RNA nucleic acid platform RNA stability target protein therapeutic effect translation treat Treatment vectors [DOI] 10.1038/s41565-021-00898-0 [Article Type] Reviews
Screening of world approved drugs against highly dynamical spike glycoprotein of SARS-CoV-2 using CaverDock and machine learningResearch Article Published on 2021-05-262022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract acute respiratory syndrome angiotensin-converting enzyme 2 approved approved drug binding energy cause CaverDock CaverWeb Clinical use Cluster Contact coronavirus dataset develop drug effort FIVE homotrimer Ligand ligands machine learning Microscopy Molecular dynamics simulation MOST multivariate Protein Protein dynamics protocol pulmonary symptoms S1 subunit SARS-CoV-2 Scientific community Screening spike glycoprotein statistical Structure subunit target protein Tunnel Vaccine Virtual screening virus was obtained ZINC database [DOI] 10.1016/j.csbj.2021.05.043 PMC 바로가기 [Article Type] Research Article
Active Learning and the Potential of Neural Networks Accelerate Molecular Screening for the Design of a New Molecule Effective against SARS-CoV-2Research Article Published on 2021-05-252022-10-27 Journal: BioMed Research International [Category] [키워드] 3CL acute respiratory syndrome affecting Algorithm Analysis approach approaches approved approved drug binding binding site candidate clinically coronavirus demonstrated develop drug effective effective vaccine Effectiveness generate global pandemic Health Host human cells inhibiting involved learning majority molecule network Neural New new virus performed polyprotein posttranslational modification Potential protease Replication respiratory virus SARS CoV-2 SARS-CoV-2 Screening small molecule subject target protein therapy transfer urgency virus viruses [DOI] 10.1155/2021/6696012 PMC 바로가기 [Article Type] Research Article
Active Learning and the Potential of Neural Networks Accelerate Molecular Screening for the Design of a New Molecule Effective against SARS-CoV-2Research Article Published on 2021-05-252022-10-27 Journal: BioMed Research International [Category] COVID-19, SARS, [키워드] 3CL acute respiratory syndrome affecting Algorithm Analysis approach approaches approved approved drug binding binding site candidate clinically coronavirus demonstrated develop drug effective effective vaccine Effectiveness generate global pandemic Health Host human cells inhibiting involved learning majority molecule network Neural New new virus performed polyprotein posttranslational modification Potential protease Replication respiratory virus SARS CoV-2 SARS-CoV-2 Screening small molecule subject target protein therapy transfer urgency virus viruses [DOI] 10.1155/2021/6696012 PMC 바로가기 [Article Type] Research Article
Kinase Inhibitors as Underexplored Antiviral AgentsPerspective Published on 2021-05-102022-10-29 Journal: Journal of medicinal chemistry [Category] COVID-19, [키워드] acting agent antiviral agent cellular dependent on drug drug resistance Effectiveness ENhance event Health help Host in viral Infection kinase Kinase inhibitor Perspective Phosphorylation Protein repurposing stages target target protein Therapeutic strategies viral genome viral infection virus [DOI] 10.1021/acs.jmedchem.1c00302 PMC 바로가기 [Article Type] Perspective
Analysis of natural compounds against the activity of SARS-CoV-2 NSP15 protein towards an effective treatment against COVID-19: a theoretical and computational biology approachCOVID-19에 대한 효과적인 치료를 위한 SARS-CoV-2 NSP15 단백질의 활성에 대한 천연 화합물 분석: 이론 및 컴퓨터 생물학 접근Article Published on 2021-05-082022-09-11 Journal: Journal of molecular modeling [Category] SARS, 치료제, [키워드] Analysis approach calculate caused Combination Community complex Compound COVID-19 cumulative death effective EndoU enzyme high risk Infectious disease inhibitor inhibitory Interaction molecular docking molecular dynamics Molecular dynamics simulation nCoV No effective drug Novel coronavirus Nsp15 pandemic processed Protein PubChem public health representing SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Side effect stability suggested target protein Treatment Vaccine viral infection Viral protein Virtual screening virus [DOI] 10.1007/s00894-021-04750-z PMC 바로가기 [Article Type] Article
Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19Article Published on 2021-05-052022-10-04 Journal: Scientific Reports [Category] SARS, 임상, 치료제, [키워드] alleviate analyzed anti-inflammatory agents anti-inflammatory drug approach approved binding affinity Biotechnology Cell Clinical efficacy Computational biology and bioinformatics Coronavirus disease 2019 COVID-19 docking score drug enrichment analysis excessive inflammation exhibited FDA food genetics Health care highest indomethacin inhibition KEGG Kyoto MAPK10 MAPK8 mechanism Medical research Molecular biology molecular docking network network pharmacology NSAID NSAIDS overlapping Pathway enrichment analysis Patient prediction proinflammatory Protein PubChem RAS Rofecoxib RStudio SARS-CoV-2 selected signaling pathway target target protein target proteins the binding affinity tissue Venn diagram was determined were used [DOI] 10.1038/s41598-021-88313-5 PMC 바로가기 [Article Type] Article
Screening of drug databank against WT and mutant main protease of SARS-CoV-2: Towards finding potential compound for repurposing against COVID-19Research article Published on 2021-05-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 변종, 신약개발, 치료제, [키워드] active against atorvastatin clinical manifestations COVID-19 database drug candidate effective Efficacy Imiglitazar Like main protease Montelukast MPro mutant mutants Mutation mutations other compound PF-00610355 PF-03715455 pharmacological agent protease Protein RdRP RNA-dependent RNA polymerase Salvianolic acid A SARS-CoV-2 screened Screening selected spike target protein the SARS-CoV-2 therapeutic therapeutic drug Treatment unique Virtual screening viruses while wild type [DOI] 10.1016/j.sjbs.2021.02.059 [Article Type] Research article