targeted therapy – Page 7 – Communicable Diseases Research

Developing a Screening Procedure During the COVID-19 Pandemic: Process and Challenges Faced by a Low-Incidence Area

Medicine

Published on 2021-12-242022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

SARS-CoV-2–host cell surface interactions and potential antiviral therapies

Articles

Published on 2021-12-102022-10-29
Journal: Interface Focus [Category] COVID-19,

Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets

코로나바이러스 감염 관련 세포 사멸 신호 및 잠재적 치료 표적

Review

Published on 2021-12-092022-09-10
Journal: Molecules [Category] SARS, 치료제,

[키워드] (RdRp 3CLpro ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-apoptotic Anti-inflammatory antiviral properties Apoptosis assembly autophagy BCL-2 can be used caused celastrol cell death cell death pathways Chloroquine chloroquine/hydroxychloroquine Compound coronavirus CoV infection COVID-19 COVID-19 treatment Critical Curcumin cysteine Cytokines death deaths Effect Efficacy enzyme expression FIVE flavonoids Frame group Helicase host cell Hydroxychloroquine induce Infection Inflammation inhibiting inhibitor Inhibitory effects interactions involved L-cysteine life cycle mechanism mitigate modify molecular target molecules MPro name natural natural compounds necroptosis NF-κB NF-κB signaling NLRP3 inflammasome non-structural protein nonstructural protein 1 nsp1 Nsp12 occurred Open reading frame ORF7a outcomes Papain play roles PLPro Potential progression proliferation promote Propagation protease Protein proteinase pyroptosis RdRP Regulated cell death Replication responsible RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV infection SARS-CoV-2 SARS-CoV-2-infected patients Serine serine 2 severe acute respiratory syndrome Coronavirus Signaling small molecule specific inhibitor spike Spike protein survival target targeted therapy the disease therapeutic targeting TMPRSS2 TNF transmembrane transmembrane protease serine 2 Treatment variety Viral viral entry viral infection viral life cycle virions XIAP yielding
[DOI] 10.3390/molecules26247459 PMC 바로가기 [Article Type] Review

COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes

Observational Study

Published on 2021-12-012022-10-04
Journal: Hematology/oncology and stem cell therapy [Category] 임상, 치료법,

[키워드] age all-cause mortality Analysis analyzed anticancer appear Cancer cancer patient cancer treatment Chemotherapy chi-square test Chicago Clinical characteristics clinical feature country COVID-19 COVID-19 test death diagnosed with COVID-19 driven by Evidence greater had no high risk hormonal therapy identify Inc. Infection median age Memorial metastatic disease Mild symptom Mortality outcome Pakistan palliative intent parameter Patient patients positive primary endpoint Purposive sampling Radiological Diagnosis Radiotherapy receive receiving retrospective risk risk of death RT-PCR severe coronavirus disease severe symptom SPSS statistically significant targeted therapy the disease Treatment USA was performed were excluded with COVID-19
[DOI] 10.1016/j.hemonc.2020.12.001 PMC 바로가기 [Article Type] Observational Study

REGEN-COV ® antibody cocktail bioanalytical strategy: comparison of LC-MRM-MS and immunoassay methods for drug quantification

REGEN-COV ® 항체 칵테일 생물분석 전략: 약물 정량을 위한 LC-MRM-MS 및 면역분석 방법의 비교

Comparative Study

Published on 2021-12-012022-09-12
Journal: Bioanalysis [Category] MERS, SARS, 진단,

Predictors of poor seroconversion and adverse events to SARS-CoV-2 mRNA BNT162b2 vaccine in cancer patients on active treatment

활성 치료 중인 암 환자에서 SARS-CoV-2 mRNA BNT162b2 백신에 대한 불량한 혈청 전환 및 유해 사례의 예측인자

Observational Study

Published on 2021-12-012022-09-11
Journal: European journal of cancer (Oxford, England : 1990 [Category] MERS, SARS, 바이오마커, 임상, 진단,

[키워드] 95% CI Active surveillance active treatment adverse effects adverse event adverse events Antibody Response Antibody responses Antibody responses to the BNT162b2 vaccine benefit BNT162b2 BNT162b2 vaccine Cancer Cancer biological treatment cancer chemotherapy Cancer hormone therapy Cancer immunotherapy cancer patient Cancer patients Cancer target therapy candidate Chemotherapy ClinicalTrials conducted controls COVID-19 vaccine COVID-19 vaccine in cancer patients dose enrolled Factor female greater Hormone therapy IgG IgG response immunisation immunogenicity increasing age lack lymphocyte Lymphocyte count medications Mild mRNA BNT162b2 vaccine non-responders occur of BNT162b2 Older age Patient patients Patients with cancer predict predicted primary endpoint Prospective Study recruited responders risk S1/S2 SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccine adverse effects. second dose Seroconversion Serological testing significantly subject targeted therapy Therapies therapy Treatment women younger patient younger patients younger subject younger subjects
[DOI] 10.1016/j.ejca.2021.09.030 PMC 바로가기 [Article Type] Observational Study

Safety of COVID-19 mRNA Vaccines in Patients with Cancer Enrolled in Early-Phase Clinical Trials

Article

Published on 2021-11-202022-10-31
Journal: Cancers [Category] COVID-19,

[키워드] adverse effect adverse event AEs anticancer approved drugs cancer patient Cancer patients clinical clinical trial clinical trials cohort study Compound compounds COVID and cancer COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines development division drug drug combinations early-phase clinical trials Efficacy Efficacy and safety enrolled Enrollment European first dose General population Immune checkpoint inhibitors Immunotherapy include investigated Local Mild moderate MOST mRNA New novel immunotherapy Patient Patients with cancer phase one trial profiles question receive receiving required retrospective Safe Safety safety profile SARS-CoV-2 second dose simple solid tumors Support systemic AEs targeted therapy the patient the vaccine treated Treatment Trial trials Vaccine
[DOI] 10.3390/cancers13225829 PMC 바로가기 [Article Type] Article

NK and T Cell Immunological Signatures in Hospitalized Patients with COVID-19

COVID-19로 입원한 환자의 NK 및 T 세포 면역학적 특징

Article

Published on 2021-11-152022-09-11
Journal: Cells [Category] MERS, SARS, 치료기술, 치료제,

[키워드] Activation acute respiratory syndrome analysed caused CD16 CD25 CD56 CD69 China Clinical severity Concentration control groups coronavirus coronavirus 2 correlation COVID-19 COVID-19 infection COVID-19 patient cytokine cytokine release Cytokines cytomegalovirus died Direct enrolled flow cytometry Frequency healthy subject hospitalised patient human population IL-6 immune response immunology increase in inhibitory involved lung transplant maintain Mild moderate modulate Multiplex assay NK cell NK cells NKG2A overexpression Patient patients with COVID-19 PD-1 phenotype progression reported respiratory SARS-COV-2 infection serum serum cytokines Severe acute respiratory syndrome severe COVID-19 patients severe disease signature significantly higher Stimulation stratified subset Survivors T cell T cell subset T cells T-cell responses targeted therapy Viral viral infections with COVID-19 Wuhan
[DOI] 10.3390/cells10113182 PMC 바로가기 [Article Type] Article

Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19

Microbiology

Published on 2021-11-152022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Prevalence and Impact Factors of COVID-19 Vaccination Hesitancy Among Breast Cancer Survivors: A Multicenter Cross-Sectional Study in China

Medicine

Published on 2021-11-032022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] 95% CI Adverse reactions Analysis analyzed Breast Breast cancer Cancer cancers Characteristics China Community conducted COVID-19 cross-sectional effective Endocrine Evidence Factor greatly reduce Hesitancy high risk hospital identify Impact infected with COVID-19 Infection information Interaction media multicenter multivariable logistic regression Odds ratio Patient patients performed poor prognosis positive Prevent questionnaire refusal reported researcher spread of COVID-19 survivor Survivors targeted therapy Treatment univariable vaccination vaccination rate Vaccine hesitancy Wuhan
[DOI] 10.3389/fmed.2021.741204 PMC 바로가기 [Article Type] Medicine