the strongest – Page 7 – Communicable Diseases Research

Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis

게놈 전반에 걸친 상위성 분석으로 식별된 저항성, 독성 및 핵심 기계 유전자의 상호 작용 네트워크

Research Article

Published on 2017-02-162022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

Strong Selection at MHC in Mexicans since Admixture

혼합 이후 멕시코의 MHC에서 강력한 선택

Research Article

Published on 2016-02-102022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 ( IFNL4 )

개선된 바이러스 제거와 관련된 변이체에 대한 선택은 인터페론 람다 4(IFNL4)의 국소적 적응형 가성화를 유도합니다.

Research Article

Published on 2014-10-162022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] ABC adaptive allele America Antiviral antiviral activity approach Approximate Asia Asian association Bayesian clearance complex conserved disease drive driving East Elimination ENCODE environmental force Europe European Evidence evidence of fixation Frame Frequency functional Genetic genetic association Genetic variant Genetic variation groups HCV hepatitis C hepatitis C virus heterogeneity Human human populations IFN-λ IFNL4 Improved inactivation Infection insertion Interferon lambda Lambda mammal mammals Migration moderate Mutation Open reading frame phenotype phenotypic diversity Population populations positive Positive selection Protein provide pseudogene raise raising reached resulting Selection selective SNP SNPs strength susceptibility the strongest turn variant virus
[DOI] 10.1371/journal.pgen.1004681 PMC 바로가기 [Article Type] Research Article

Genome-Wide Analysis in German Shepherd Dogs Reveals Association of a Locus on CFA 27 with Atopic Dermatitis

German Shepherd Dogs의 게놈 전체 분석을 통해 아토피 피부염과 CFA 27에 대한 유전자좌 연관성 밝혀

Research Article

Published on 2013-05-092022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] addition affected age allergic skin Analysis analysis association atopic dermatitis Author block blocks CAD canine caused CFA chromosome Cohort compared complex contributing to Control correlation defined dermatitis detected develop different disease Disease prevalence division dog eight environmental factors expressed found Genes Genetic genetics Genome genome-wide association genome-wide significant genotyping German shepherd GSD Haplotype high correlation Human IgA level IgA levels included indicate Interaction mixed model approach parameters performed PKP2 plakophilin population stratification Prevalence sampling separation Sequencing serum significantly significantly lower skin disease SNPs study population subpopulation subpopulations subset Swedish the strongest was performed was used
[DOI] 10.1371/journal.pgen.1003475 PMC 바로가기 [Article Type] Research Article

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

MicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다

Research Article

Published on 2013-02-282022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 3′ UTR 3′UTR activate affecting African Americans allelic Americans Antigen Asian Asians association Author Autoimmune Autoimmune disease binding binding site C allele C-allele carriers conducted contributed Control copy number correlated debilitating autoimmune disease decrease Degradation dose-dependent downregulated driven by duplication elevated Epigenetic European Evidence exhibited exhibiting expression functional G allele G-allele genomic greater HEK-293 HEK-293 cell HEK-293 cells Human identify IFN IFN-α pathway increased risk independent individual innate immune activation lack led to luciferase luciferase activity Lupus lupus erythematosus lupus-like disease mechanism microRNA microRNA-3148 microRNA–gene miR-3148 modulation mononuclear cell mononuclear cells mRNA murine model non-risk allele non-risk C allele nuclear nucleotide Odds ratio overexpression Pathways PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells polymorphism predicted promote Protein protein level provide R 2 reduction regulate Regulatory reported reporter reporter gene respond resulting risk sequence signaling pathways significantly increased single nucleotide Single nucleotide polymorphism SLE SLE patient SLE patients SNP subject susceptibility systemic systemic lupus erythematosus the strongest These data TLR7 TLR7 gene TLR7 mRNA TLR7-TLR8 region TLR7/8/9 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors transcript transcript level transcripts transfected cells type I interferon UTR variant Variation while
[DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article

The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove

HLA 클래스 I 항원 인식 그루브와 관련된 중국 비인두암의 주요 유전적 결정인자

Research Article

Published on 2012-11-292022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] allele allele frequencies alleles Amino acid Analysis analyzed antigens association associations Author binding Cancer carcinoma carried China Chinese chromosome chromosome 6 class Cohort concert dependent on detect detected determinant disease driven by EBV epithelial Epstein-Barr virus examined facilitated GABBR1 Gene gene region genetic influence Genome-wide association study Groove Guangdong Guangxi GWAS HCG9 help High-resolution HLA HLA alleles HLA class I HLA class I gene HLA region HLA-A HLA-A and -B HLA-B HLA-F incidence independent Infection influences influences on Interaction involved large cohort Linkage disequilibrium malignancy molecular motif multivariate Nasopharyngeal carcinoma NPC nucleotide operative OR2H1 over peptide performed physically principal Recognition recognize Region regression analysis replicate Replication resolved risk second sequence SNP SNPs statistical study participant the major histocompatibility the strongest variant variants virus infection
[DOI] 10.1371/journal.pgen.1003103 PMC 바로가기 [Article Type] Research Article

Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies

서아프리카 피그미족의 조상 패턴, 자연 선택의 서명 및 키와의 유전적 연관성

Research Article

Published on 2012-04-262022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] adaptive African Anatomy ancestry approach association Author average candidate gene chromosome chromosome 3 CISH Cluster cytokine cytokine signaling demography DOCK3 enrichment European Europeans Evolution extreme found Gene Genetic genetic association genetic diversity Genome genomic region globe group growth growth factor growth hormone Height highest Human human population human populations identify Illumina Immunity include indicate inhibit insulin insulin-like growth factor involved Local location loci metabolism natural natural selection neuroendocrine Pathway analysis Pathways pattern phenotypic phenotypic diversity phenotypic variation Physiology Population Positive selection Region regulate reproduction Selection short stature Signaling signaling pathways signature SNP stature target targets the strongest thought tropical unique variant variants Variation
[DOI] 10.1371/journal.pgen.1002641 PMC 바로가기 [Article Type] Research Article