Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytesArticle Published on 2022-01-282022-10-04 Journal: Communications Biology [Category] 바이오마커, [키워드] Analysis analyzed bacterial endotoxin Characteristics Chronic diseases chronic inflammation condition contribute COVID-19 driving Epigenetic epigenomic epigenomics evaluate expression Gene Expression Genes High dose High-dose immune induce Inflammation interferon response low dose low-dose low-grade inflammation LPS marrow-derived macrophage memory Modification monocyte murine occur Pathogenesis pathogenic pathway Pathways PBS proliferative Regulation responses Sepsis Signaling target the cell therapeutic TLR4 transcriptomic underlie upregulate while [DOI] 10.1038/s42003-022-03035-2 PMC 바로가기 [Article Type] Article
The Landscape of Aminoacyl-tRNA Synthetases Involved in Severe Acute Respiratory Syndrome Coronavirus 2 InfectionPhysiology Published on 2022-01-262022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] acute respiratory syndrome addition Amino acid Aminoacyl-tRNA aminoacyl-tRNA synthetase analyzed co-immunoprecipitation co-IP coronavirus coronavirus 2 correlation COVID-19 CoVs cytoplasmic database develop downregulation EARS2 enzyme eukaryotic Evolution expand experiment function HARS2 highly pathogenic human CoVs identify implicated in viral Infection Interaction Interaction network involved key factor landscape M protein mitochondrial mRNA levels Organisms pathway Perspective Phosphorylation physical protein level protein synthesis proteomic provide respiratory SARS-CoV-2 SARS-COV-2 infection Synthetase TARS2 the shortest path transcriptomic translation tRNA [DOI] 10.3389/fphys.2021.818297 PMC 바로가기 [Article Type] Physiology
Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19중요한 COVID-19에서 심장 손상 및 미세 혈전에 대한 임상 조직 병리학 및 단일 핵 RNA 시퀀싱 통찰력Clinical Trial Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 임상, 진단, 치료기술, 치료제, [키워드] Acute cardiac injury Analysis antiplatelet association bioinformatics Biomarkers biomarkers of inflammation C-reactive protein cardiac injury Cardiology cardiovascular disease cause clinical factors Cohort conducted controls Corticosteroid corticosteroid treatment COVID-19 Critical enrichment erythrocyte sedimentation erythrocyte sedimentation rate etiology Extracellular matrix Features fibrinolysis fibroblast heart hearts identify In-hospital increased mortality Injury microthrombi Molecular pathology myocarditis Necrosis New York City pathophysiology Patient potential therapeutic target prevalent Prospective Study RNA-sequencing sedimentation rate Sequencing analysis Signaling tested therapeutic anticoagulation Therapies therapy transcriptomic were used [DOI] 10.1172/jci.insight.154633 PMC 바로가기 [Article Type] Clinical Trial
Dual RNA-Seq analysis of SARS-CoV-2 correlates specific human transcriptional response pathways directly to viral expressionSARS-CoV-2의 이중 RNA-Seq 분석은 특정 인간 전사 반응 경로를 바이러스 발현과 직접 연관시킵니다Article Published on 2022-01-252022-09-10 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis approach bioinformatics cascade caused chemokine coronavirus determine differential expression Differential expression analysis drug target Effect explain expression future therapeutic Health help highlight host responses in viral Infection introduced involved lipopolysaccharide mechanism new strain offer pathway Pathways Patient promise reaction Research RNA sequencing SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 transcriptomes Society specificity therapeutic intervention therapeutic interventions tissue transcriptional response transcriptomes transcriptomic Vaccine Vaccines Viral viral infection virus [DOI] 10.1038/s41598-022-05342-4 PMC 바로가기 [Article Type] Article
A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infectionsClinical Trial Published on 2022-01-182022-10-04 Journal: Scientific Reports [Category] 바이오마커, 임상, 진단, 치료제, [키워드] 30-Day mortality acute viral infection assist Care Classifier clinical study Cohort COVID-19 determine develop enrolled facilitate Gene Expression healthcare Host Host immune response host response illnesses implementation in viral independent Infection Infectious diseases Influenza isothermal Logistic Logistic regression machine learning management medical need Molecular medicine outcome Patient predict Prognostic markers reducing retrospective retrospective cohort risk RNA RNAs selected severe respiratory failure severity severity of COVID-19 Statistical methods training data transcriptomic Viral illness viral infection Whole blood [DOI] 10.1038/s41598-021-04509-9 PMC 바로가기 [Article Type] Clinical Trial
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation심각한 COVID-19 환자의 사후 고차원 면역 프로파일링은 면역 억제 및 면역 활성화의 독특한 패턴을 나타냅니다Article Published on 2022-01-122022-09-10 Journal: Nature Communications [Category] 바이오마커, 치료기술, 치료법, [키워드] activated Activation Analysis antigens approach Autopsy Cell cell type cell types cells Complete coronavirus disease Coronavirus disease 2019 correlation correlations COVID-19 COVID-19 disease Deceased dendritic cell diagnostic distal etiology function Gene regulation in immune cells hallmark histological Imaging the immune system immune profiling immune response immune responses Immunosuppression induce information lymphocyte Lymphocytes men multiple organs myeloid cell myeloid cells Pathogenesis PD-1 Postmortem prevalent progression proximal reveal SARS-COV-2 infection SARS-CoV-2 viral SARS-CoV-2 viral infection severe COVID-19 severe COVID-19 disease severe COVID-19 patient Systems analysis therapy these cell These cells transcriptional transcriptomic Viral Viral antigen viral antigens viral infection Viral load Wuhan Wuhan, China [DOI] 10.1038/s41467-021-27723-5 PMC 바로가기 [Article Type] Article
COVID19db: a comprehensive database platform to discover potential drugs and targets of COVID-19 at whole transcriptomic scaleCOVID19db: 전체 전사체 규모에서 COVID-19의 잠재적 약물 및 표적을 발견하기 위한 포괄적인 데이터베이스 플랫폼AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] 유전자 메커니즘, 치료제, [키워드] accelerate Analysis clinical information coronavirus disease Coronavirus disease 2019 COVID-19 database dataset datasets drug Effective strategies effective strategy facilitate grouping heterogeneity identify include Interaction mandatory mechanism microbe Open Access platform proof proof of concept provide researcher target targets Transcriptome transcriptomes transcriptomic transcriptomic data [DOI] 10.1093/nar/gkab850 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Pathological Change of Chronic Hepatitis B Patients with Different Tongue Coatings by Circular Multi-Omics Integrated AnalysisArticle Published on 2022-01-012023-06-12 Journal: Chinese journal of integrative medicine [Category] B형 간염, [키워드] Chinese medicine Chronic Hepatitis B metabolomics tongue diagnosis transcriptomic [DOI] 10.1007/s11655-020-3275-4
Systems Biology and Bioinformatics approach to Identify blood based signatures molecules and drug targets of patient with COVID-19Research article Published on 2021-12-302022-10-05 Journal: Informatics in Medicine Unlocked [Category] 바이오마커, [키워드] acute respiratory syndrome approach association AURKB bioinformatics Biology Biomarker Biomarker signatures Blood blood cell Blood cells Blood common gene BUB1B CCNB1 Cell connection contagious Coronavirus-2 COVID-19 dataset DEGs diagnose differentially expressed gene Differentially expressed genes disease DLGAP5 drug target effective Gene Expression Gene ontology HJURP hub protein Identified identify infected with SARS-CoV-2 Infection KIF11 Microarray molecular MONITOR mononuclear cell NCAPG New coronavirus Ontology pathophysiology pathway patient with COVID-19 patients with COVID-19 PBMCs PBMCs cell performed Peripheral blood prevalence of COVID-19 progression Research SARS-CoV-2 signaling pathways subjects System therapeutic intervention TOP2A TPX2 transcript transcriptomic Treatment TTK with COVID-19 [DOI] 10.1016/j.imu.2021.100840 [Article Type] Research article
Integration of whole genome sequencing and transcriptomics reveals a complex picture of the reestablishment of insecticide resistance in the major malaria vector Anopheles coluzzii전체 게놈 시퀀싱 및 전 사체의 통합은 주요 말라리아 벡터 Anopheles coluzzii에서 살충제 저항성의 재건에 대한 복잡한 그림을 보여줍니다.Research Article Published on 2021-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] alteration Anophele approach block change changes in colony complex complexity determine diagnostic Diagnostic markers elevated expression of gene Genetic genetic background Genome genomic genomic change increase in increased respiratory rate increasingly insecticide integration inversion Laboratory malaria malaria control malaria vector marker mechanism metabolism microbial Microbiome original oxidative phosphorylation pathway phenotype Population Pyrethroids respiratory rate reveal RNAseq Sequencing subject subset susceptible Transcriptome transcriptomic transcriptomics translated whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1009970 PMC 바로가기 [Article Type] Research Article