Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3Original Article Published on 2016-04-202022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Activation antiviral response association C-terminal C-terminal domain characterized chimeric claimed conserved contribute evade ex vivo models expression highly pathogenic Host IFN induce infected patient Infection inhibitory effect innate antiviral response interferon IRF3 IRF3 activation M protein mechanism MERS coronavirus MERS-CoV Middle East mutants N-terminal nuclear Pathogenesis Phosphorylation Protein reduced Regulatory respiratory syndrome coronavirus resulting RIG-I-like receptors SARS-CoV Saudi Arabia Sendai virus suppress suppresse suppressed TRAF3 transmembrane domain Type I IFN type I interferon type I interferons [DOI] 10.1038/emi.2016.33 PMC 바로가기 [Article Type] Original Article
A molecular arms race between host innate antiviral response and emerging human coronavirusesReview Published on 2016-01-152023-06-15 Journal: Virologica Sinica [Category] MERS, [키워드] immune evasion innate antiviral response MERS-CoV SARS-CoV type I interferons [DOI] 10.1007/s12250-015-3683-3 PMC 바로가기 [Article Type] Review
Unraveling the Convoluted Biological Roles of Type I Interferons in Infection and Immunity: A Way Forward for Therapeutics and Vaccine Designarticle Published on 2014-08-292024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] Human immunodeficiency virus IFN-ε interferon immunity type I interferons Vaccine adjuvants [DOI] 10.3389/fimmu.2014.00412 PMC 바로가기 [Article Type] article