Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic strokeReview Published on 2021-05-312022-10-30 Journal: Journal of Neuroinflammation [Category] COVID-19, [키워드] activated Activation approach Brain CIITA Clinical treatment complex component components death detect disease domain downstream drug dysfunction edema Effect effective Evidence genes encoding Immune cell increasingly Inflammasome Inflammation inflammatory pathways Inflammatory response inherent innate immune cell involved Ischemia Ischemic Stroke manuscript MAPK Mortality NAIP nerve cell NF-κB NLR NLRP3 NLRP3 inflammasome nuclear oligomerization pathogen invasion pathway pattern recognition receptor populations proinflammatory cytokines promote Protein PRR PRRs reactive oxygen species receptor signaling pathway stroke target therapeutic strategy therapy tissue damage Transcription understanding upstream [DOI] 10.1186/s12974-021-02137-8 PMC 바로가기 [Article Type] Review
Health Related Social Needs Among Chinese American Primary Care Patients During the COVID-19 Pandemic: Implications for Cancer Screening and Primary CareCOVID-19 팬데믹 기간 동안 중국계 미국인 1차 진료 환자의 건강 관련 사회적 요구: 암 검진 및 1차 진료에 대한 시사점Public Health Published on 2021-05-282022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, [키워드] 95% CI age All participants American anticipated Asian Asian American (AA) Cancer Cancer screening Chinese cohesion Community conducted Course COVID-19 COVID-19 pandemic Critical develop effort English food insecurity Health higher odd higher odds highest highlight impacted IMPROVE initiative instability life New Older age outcome participant Participants pathway Patient patients Prevalence primary care reported resource Screening significantly social determinant social determinants social needs subset Trust upstream utility [DOI] 10.3389/fpubh.2021.674035 PMC 바로가기 [Article Type] Public Health
Induction of the Proinflammatory Chemokine Interleukin-8 Is Regulated by Integrated Stress Response and AP-1 Family Proteins Activated during Coronavirus InfectionArticle Published on 2021-05-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] acute respiratory syndrome antiviral immunity AP-1 AP-1 family proteins caused Cell cellular chemokine cJUN and cFOS complex interaction coronavirus coronavirus disease Coronavirus infection COVID-19 Cytokine release syndrome demonstrated double-stranded eIF2α eIF2α epidemic diarrhea eukaryotic translation facilitate family highlighting IBV IBV-infected cells IL-6 IL-8 induce induction Infection Infectious Bronchitis Virus innate immune response integrated stress response interleukin-8 investigated life-threatening Local mRNA expression mutant overexpression pathway PKR Proinflammatory cytokine Protein Regulatory response SARS-CoV-2 Severe case significantly Stress unfolded protein response upregulation upstream virus [DOI] 10.3390/ijms22115646 PMC 바로가기 [Article Type] Article
Demolishing the Myth of the Default Human That Is Killing Black MothersPublic Health Published on 2021-05-242022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] agency approach black Black maternal health black people Care disrupt Effect equity Evidence Frame global pandemic Health Health crisis Health Service Human less Maternal Monument myth Pregnancy public health public health praxis recommendation reproductive Research Structural racism Taylor upstream Washington women [DOI] 10.3389/fpubh.2021.675788 PMC 바로가기 [Article Type] Public Health
Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus PatientsArticle Published on 2021-05-172022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] absence ACE2 ACE2 expression acute respiratory syndrome addition affected affecting age angiotensin-converting enzyme 2 association Biomarker Biomarkers BMI body mass index circulating circulation collected Comorbidities complications coronavirus coronavirus disease correlated COVID-19 Demographic factors detectable Diabetic diabetic patients ELISA enzyme-linked immunosorbent Epigenetic Factor Factors Gender groups healthy controls host receptor in silico analysis include Infection lung microRNA miRNA miRNAs multiple organ failure non-coding RNA Non-invasive obesity other organs pandemic Patient patients protease quantified quantitative PCR reveal reverse transcription RNA RT-qPCR sACE2 SARS-CoV-2 serine 2 serum Serum level serum sample soluble ACE2 TaqMan TMPRSS2 transmembrane Type type 2 diabete Type 2 diabetes mellitus upstream viral entry was performed with COVID-19 [DOI] 10.3390/ijms22105263 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway EpitheliaResearch Article Published on 2021-05-112022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Air-liquid interface Amino acid cellular protease coronavirus Culture Deletion Donor Dynamics epithelia Evidence FCS furin cleavage site HAE healthy Human human airway epithelia human airways Infection Lung disease maintain mutated patients primary human airway processed released retained S1 and S2 S1/S2 boundary SARS-CoV-2 selective Site stability subunit transcript Transcriptome unique upstream Vero Vero cells viral genome viral transcriptome virion while [DOI] 10.1128/mBio.01006-21 PMC 바로가기 [Article Type] Research Article
Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain–based vaccine candidate, RBD219-N1C1Biotechnological Products and Process Engineering Published on 2021-05-072022-10-28 Journal: Applied Microbiology and Biotechnology [Category] COVID-19, SARS, [키워드] Abstract ACE2 receptor binding addition Antigen clinical testing condition COVID-19 COVID-19 vaccine downstream elicit fermentation generate good manufacturing practice include mice Neutralizing antibody response performed Pichia pastoris Process produced Protein protocol purification purified Receptor binding recombinant COVID-19 vaccine robust SARS-CoV-2 SARS-CoV-2 pseudovirus SEC-HPLC shown Spike protein supplementary material the SARS-CoV-2 upstream vaccine candidate yeast [DOI] 10.1007/s00253-021-11281-3 PMC 바로가기 [Article Type] Biotechnological Products and Process Engineering
Killed whole-genome reduced-bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model죽은 전체 게놈 감소 박테리아 표면 발현 코로나 바이러스 융합 펩티드 백신은 돼지 모델에서 질병으로부터 보호합니다423 Published on 2021-05-042022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] Amino acid amino acid residues anamnestic response Bacteria Bacterial Betacoronavirus Cell cell surface clinical disease conserved core coronavirus coronavirus disease Coronavirus disease 2019 coronavirus vaccine COVID-19 cross-protection demonstrated diarrhea disease downstream Efficacy elicited ENhance epidemic diarrhea Escherichia coli evaluated Express expressing expression vector fusion peptide genome-reduced bacteria vaccine platform highly conserved fusion peptide immune system Immunity Interaction interferon interferon-γ offer pandemic Pathogens PEDV peptide PIGS platform porcine epidemic diarrhea virus (PEDV) principle proof PROTECT Protective provide provided reduced residue responses SARS-CoV-2 sequence Significance sterilizing immunity target tested tissue Transport upstream utility Vaccine vaccine antigen vaccine immunogenicity vaccine platform Vaccines viral RNA load virus whole-genome [DOI] 10.1073/pnas.2025622118 PMC 바로가기 [Article Type] 423
A Data-Driven Simulation of the Exposure Notification Cascade for Digital Contact Tracing of SARS-CoV-2 in Zurich, SwitzerlandResearch Published on 2021-04-302022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, SARS, [키워드] Analysis bottleneck cascade checked Contact Contact tracing country DCT defined demonstrated Digital distribution downstream Effectiveness estimate evaluated exposure finding help Importance incidence information internal consistency limit longitudinal mandatory measure notification objective pandemic parameter participant Point Population positive positive result Positive test positive test result quarantine reached receiving recommendation released Relevance Research Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test SARS-CoV-2 testing SARS-CoV-2 transmission SARS-CoV-2–positive setting Simulation stochastic Switzerland tracing Transmission Trigger triggered upstream was performed [DOI] 10.1001/jamanetworkopen.2021.8184 PMC 바로가기 [Article Type] Research
Identification of PBMC-based molecular signature associational with COVID-19 disease severityResearch article Published on 2021-04-212022-10-05 Journal: Heliyon [Category] 바이오마커, [키워드] administration admitted to ICU affected Analysis antiviral response associational Biomarker Biomarkers canonical clinical implications coding mRNA COVID-19 COVID-19 patient dataset disease disease severity Effect expressed function global pandemic identification implication individual interferon lncRNA long noncoding RNA molecular mRNA Non-COVID-19 Patient patients patients with COVID-19 PBMC PBMCs Protein SARS-CoV-2 severe COVID-19 severity significantly Stratification subset suppressed Therapeutic approach therapeutic option therapy Transcriptome turn upstream with COVID-19 [DOI] 10.1016/j.heliyon.2021.e06866 [Article Type] Research article