viral life cycle – Page 7 – Communicable Diseases Research

Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication

SARS-Cov-2 뉴클레오캡시드 단백질의 아르기닌 메틸화는 RNA 결합, 스트레스 과립 형성 억제 능력 및 바이러스 복제를 조절합니다

Research Article

Published on 2021-05-232022-09-10
Journal: The Journal of Biological Chemistry [Category] SARS, 치료법,

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis

게놈 전반에 걸친 생물정보학 분석으로 SARS-CoV-2 발병의 주요 숙주 및 바이러스 요인 예측

Article

Published on 2021-05-172022-09-10
Journal: Communications Biology [Category] SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age Analysis analyzed Betacoronavirus caused Computational biology and bioinformatics conserved contribute coronavirus COVID-19 CSF2 differentially expressed eIF4b eukaryotic Factor Genes help heterogeneous hnRNPA1 Host host gene expression host response host–pathogen interactions human gene human genes human respiratory cell human respiratory cells identify IL-6 IL32 Infection initiation factor interact Interaction isoform isoforms life cycle mechanism novel Betacoronavirus nuclear predict predicted Protein reduce respiratory respiratory cells ribonucleoprotein RNA SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 pathogenesis sequence sequencing data SERPINA3 severe acute respiratory syndrome Coronavirus severity of COVID-19 statistically significant the SARS-CoV-2 genome Therapeutics transcriptomics transposable element upregulated variant Viral viral genome sequence viral infection viral life cycle Viral RNA worldwide pandemic Wuhan Wuhan, China
[DOI] 10.1038/s42003-021-02095-0 PMC 바로가기 [Article Type] Article

Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining

Pharmacology

Published on 2021-05-142022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] addition administration Against analyzed Anti-viral anti-viral responses antiviral activity broad-spectrum antivirals Capacity Capsule China Chinese clinical outcomes combined treatment COVID-19 drug Efficacy exhibit exhibited Fatality rate food function Granule Host Host immune response host-directed therapy immune function infected patient Inflammation International Jin-Hua-Qing-Gan granule Lian-Hua-Qing-Wen capsule literature medicinal plants Medicine modulating novel coronavirus disease Patient pharmacological SARS-CoV-2 Statistics Symptom the disease Traditional Treatment variety viral infections viral life cycle
[DOI] 10.3389/fphar.2021.640782 PMC 바로가기 [Article Type] Pharmacology

Clinical features and prognostic factors in Covid-19: A prospective cohort study

Covid-19의 임상 특징 및 예후 요인: 전향적 코호트 연구

Multicenter Study

Published on 2021-05-142022-08-31
Journal: EBioMedicine [Category] 바이오마커,

[키워드] Adhesion Molecule Admission Analysis Angiogenesis angiopoietin association Biomarker Blood CD14 cell adhesion molecule cell-cell adhesion changes in chemotaxis clinical Clinical deterioration Clinical features Coagulation Cohort complement complement component complement system Concentration Corona Corticosteroids COVID-19 COVID-19 infection Cox regression death Deterioration died Disease progression driven by End end products Endothelial dysfunction feature fibrinolysis finding funding Glycation group hospitalized patient hospitalized patients host response ICU ICU Patients IL-1-receptor IL-10 IL-6 IL-8 immunothrombosis Inflammation insight interleukin Intubated involved joint lactoferrin lead life cycle linear marker mechanisms mixed-effects models Mortality multiple pathways Necrosis outcome overlap pathway Pathway analysis Pathways Patient patients died patients with COVID-19 performed Primary outcome procalcitonin product Prognosis Prognostic factor Prognostic markers prospective cohort study receptor receptor antagonist Regulation risk severe COVID-19 therapy tissue tissue damage Tissue Factor transferred Treatment strategies Tumor tumor necrosis tumor necrosis factor urokinase Urokinase-Type Plasminogen Activator variety vascular cell adhesion VCAM-1 Viral viral life cycle ward with COVID-19 wound healing
[DOI] 10.1016/j.ebiom.2021.103378 PMC 바로가기 [Article Type] Multicenter Study

Discovery of SARS-CoV-2 main protease inhibitors using a synthesis-directed de novo design model †

Chemistry

Published on 2021-05-062022-11-01
Journal: Chemical communications (Cambridge, England) [Category] COVID-19, SARS,

[키워드] Antiviral assays biochemical COVID de novo develop host proteases inhibitor Live virus M pro molecular protease SARS-CoV-2 SARS-CoV-2 main protease viral life cycle
[DOI] 10.1039/d1cc00050k PMC 바로가기 [Article Type] Chemistry

Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferase

SARS-CoV-2 표적화: 3C-유사 프로테이나제 및 2'-O-리보스 메틸트랜스퍼라제에 대한 유망한 억제제를 식별하기 위한 체계적인 약물 용도 변경 접근법

Article

Published on 2021-05-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발,

[키워드] 2′-O-ribose methyltransferase 3C-like proteinase 3CLpro active site antiviral drugs approach bictegravir binding candidate computational analysis contagious Coronaviridae family cysteine cysteine protease docking dolutegravir drug Drug repurposing drug target free energy functional host immune system house identify imperative inhibitor interacting residues lead life cycle MD simulation methyltransferase mRNA nucleotide number of infected Orientation pandemic parameter paritaprevir physiological state Protein protein-drug complex protein-drug complexes proteinase Proteins proteolysis raltegravir replicase polyprotein replicase polyproteins responsible resulting ribose SARS-CoV-2 screened selected targeting targets the Coronaviridae therapeutic drug Viral viral life cycle Virtual screening virus
[DOI] 10.1080/07391102.2020.1753577 PMC 바로가기 [Article Type] Article

SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental Models

Pharmacology

Published on 2021-04-222022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ACE-2 acute respiratory syndrome Antiviral blood vessel organoid Calu-3 cause cell line cells clinical sample coronavirus COVID-19 develop drug design Drug discovery epithelial cell epithelial cells experimental model experimental models expression H1299 HEK-293 human Angiotensin-converting enzyme human lung inefficient Infection intestinal epithelial cells Intestinal Organoids investigated Laboratory lung organoids Model molecular molecular target Molecular targets morbidity and mortality mouse model Novel coronavirus outbreak outcomes pandemic Pathogenesis potential molecular Protein recent receptor Research researcher SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection sequencing data spike target targets the SARS-CoV-2 therapeutic transgenic Treatment outcome Vero cells viral genome viral life cycle viral pathogen viral pathogenesis Viral protein viral titer X-ray
[DOI] 10.3389/fphar.2021.638334 PMC 바로가기 [Article Type] Pharmacology

Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19

Article

Published on 2021-04-092022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome calu-3 cells clinical clinical isolate Combination compounds Confirmed coronavirus coronavirus disease Corticosteroid COVID-19 demonstrated drug drug combinations Drug repurposing effective drugs eight FDA-approved drug FDA-approved drugs food greater high-content screening identify illnesses in vitro infections isolate Korean late stage lung organoids medical need MERS-CoV Middle East Middle East respiratory syndrome Coronavirus option pandemic Potential Remdesivir representing respiratory syndrome coronavirus SARS-CoV-2 screened Screening selected drug severe acute respiratory syndrome coronavirus disease South South Korea tested therapeutic therapeutic option treat United State VERO-E6 viral life cycle
[DOI] 10.3390/v13040651 PMC 바로가기 [Article Type] Article

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

Report

Published on 2021-04-052022-11-01
Journal: Cell Reports [Category] COVID-19, MERS, SARS,

[키워드] Abstract ACE2 ACE2 expression Activation angiotensin-converting enzyme 2 binding caused Cell cellular cellular pathway COVID-19 dependent on downregulate fatality Health HIF-1α highlight highlighting hypoxia hypoxia, HIF, SARS-CoV-2, HIF prolyl hydroxylase inhibitor infect inhibit inhibit SARS-CoV-2 inhibitor lung epithelial cell microenvironment novel coronavirus SARS-CoV-2 oxygen oxygen tension pathway pharmacological raise reduce regulate Replication respiratory tract RNA roxadustat SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 replication Signaling spike glycoprotein the SARS-CoV-2 therapeutic therapeutic option TMPRSS2 transcriptional response Treatment viral entry viral life cycle Wing
[DOI] 10.1016/j.celrep.2021.109020 PMC 바로가기 [Article Type] Report

An Overview of Current Knowledge of Deadly CoVs and Their Interface with Innate Immunity

Review

Published on 2021-03-262022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] acute respiratory distress Administered Anti-viral ARDS China common cold-like symptoms convalescent plasma coronavirus Coronaviruses CoV COVID-19 vaccine current death deaths develop disease effective Epidemiology evade Guangdong Host human coronavirus Hydroxychloroquine immune response immune responses Immunosuppressive treatment individual infecting Infection Innate Innate immunity interface MERS-CoV Middle East Mild modulate mortality rate MOST Pathogenesis Phylogeny pro-inflammatory produced Remdesivir Research respiratory respiratory tract RNA viruses SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Saudi Arabia severity spread to syndrome target therapeutic intervention therapy Transmission Treatment type I interferon viral life cycle viral structure viruses zoonotic
[DOI] 10.3390/v13040560 PMC 바로가기 [Article Type] Review