Viral proteins – Page 7 – Communicable Diseases Research

Identification of cytotoxic T cells and their T cell receptor sequences targeting COVID-19 using MHC class I-binding peptides

MHC 클래스 I 결합 펩타이드를 사용하여 COVID-19를 표적으로 하는 세포독성 T 세포 및 T 세포 수용체 서열 확인

Article

Published on 2022-02-022022-09-10
Journal: Journal of Human Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 치료기술, 치료제,

Repurposing drugs for treatment of SARS-CoV-2 infection: computational design insights into mechanisms of action

SARS-COV-2 감염의 치료를위한 약물 용도 : 작용 메커니즘에 대한 전산 설계 통찰력

Article

Published on 2022-02-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), MERS, SARS, 신약개발, 치료법, 치료제,

[키워드] accelerate binding site Broad Institute caused ChEMBL Compound Computational drug Coronavirus infection COVID-19 COVID-19 pandemic database deaths determine develop drug Drug development Drug repurposing feature Features health emergency help human population identify in vitro in vitro data in vivo inhibit inhibitors inhibitors of SARS-CoV-2 Interaction life Ligand mechanism molecules negatively affected non-structural proteins Novel coronavirus Novel coronavirus infection nucleocapsid nucleocapsid protein pharmacophore predicted progressed Protein Protein binding Protein target protein targets repurposing Research SARS-CoV-2 SARS-CoV-2 genome screened the SARS-CoV-2 genome therapeutic intervention therapeutic interventions Treatment Viral Viral protein Viral proteins Virtual screening virus Visualisation was used
[DOI] 10.1080/07391102.2020.1825232 PMC 바로가기 [Article Type] Article

Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers

일본 인구에서 SARS-CoV2 감염에 대한 다양한 종류의 항체 반응 역학: IgA 및 IgG 역가가 IgM 역가보다 일찍 증가했습니다.

Article

Published on 2022-02-012022-09-11
Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody responses Asian association Clinical course clinical feature Clinical features coronavirus COVID-19 domain IgA IgA antibodies IgA antibody IgG IgG response IgG responses IgG titer IgM IgM and IgG IgM responses IgM seroconversion IgM/IgG immune response immune responses individuals with COVID-19 Infection Japanese Japanese population Kinetics Kinetics of antibody responses less Mild nucleocapsid protein occurred Patient Population populations Protein RBD Receptor-binding domain respiratory response S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV2 infection Seroconversion serum titer serum titers severe acute respiratory syndrome Coronavirus spike Spike protein spread of COVID-19 sustained the antibody response the S1 subunit the spike protein timeline Viral protein Viral proteins
[DOI] 10.1016/j.intimp.2021.108491 PMC 바로가기 [Article Type] Article

Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations

노화된 전혈 전사체는 SARS-CoV-2 관련 혈관 및 면역 변화에 대한 후보 유전자를 나타냅니다

Article

Published on 2022-02-012022-09-11
Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adhesion affected age aging alteration anti-apoptotic BAG3 Blood Blood clots blood component blood components candidate candidate gene cascade cathepsin Cathepsins CCL4L2 CD14 CD4 CD8 Cell changes in clinical manifestation coronavirus COVID-19 CTSE CTSW database DEGs differentially expressed gene Differentially expressed genes DUSP4 expressed expression expression levels expression profile FASL FASLG female genders gene expression profile high viral load highest HLA-DRA Hyperinflammatory identify IFN IFN signaling immune immune response increase increase in increased expression individual Inflammation interact Interaction interferon investigated involved LAG3 Monocytes naïve T cells natural killer cell Natural killer cells Older older patient older patients overexpress overexpression PDCD1 Peripheral blood Platelet prediction Protein reveal RGS2 risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients sequencing data severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling Single-cell RNA-sequencing T cell T cell exhaustion T cells T lymphocytes target targets therapeutic TIGIT TOX Transcriptome translated type I interferon Vascular VCAM1 Viral load Viral protein Viral proteins Whole blood whole blood transcriptome
[DOI] 10.1007/s00109-021-02161-4 PMC 바로가기 [Article Type] Article

Mitigating Covid-19 in the face of emerging virus variants, breakthrough infections and vaccine hesitancy

새로운 바이러스 변종, 획기적인 감염 및 백신 주저에 직면하여 Covid-19 완화

Review

Published on 2022-02-012022-09-11
Journal: Journal of autoimmunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] Antibody Response approach B cell B cell memory being booster Breakthrough infection breakthrough infections Cell condition conserved COVID-19 virus creating Critical death Delta disease effective evade facilitate follicular Germinal center Global vaccination helper cells Hospitalization Immunity immunization Interaction multivalent vaccine mutate Mutation notable omicron Omicron variant Omicron variants pandemic Perspective Proteins public health emergency resulting RNA RNA virus robust SARS-CoV-2 Second-generation vaccines Spread T follicular helper cells the antibody response translational Transmissibility Transparency vaccination Vaccine Vaccine hesitancy Vaccines variant variants variants of SARS-CoV-2 Viral viral mutation Viral mutations Viral protein Viral proteins virus virus variants
[DOI] 10.1016/j.jaut.2021.102792 PMC 바로가기 [Article Type] Review

Aptamers—Diagnostic and Therapeutic Solution in SARS-CoV-2

앱타머 - SARS-CoV-2의 진단 및 치료 솔루션

Review

Published on 2022-01-262022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 진단, 치료기술,

Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective

COVID-19의 잠재적 치료에 대한 접근: 의약 화학 관점의 일반 개요

Review

Published on 2022-01-202022-09-10
Journal: Molecules [Category] SARS, 변종, 치료제,

[키워드] 3CLpro inhibitors active against affected Anti-inflammatory antibody Antiviral arising Cell characteristic charge Chemistry corticoids Corticosteroids COVID-19 pandemic cytokine Cytokine storm drug drugs targeting elongation factor Genome host cell host protein host proteins hyperinflammatory phase IL6 antibodies Inflammatory interleukin interleukin 6 involved Jak JAK-STAT inhibitors kinases less Mutation pharmacological treatment pharmacological treatments polyprotein Potential protease Protein RdRp inhibitors S antibodies SARS-CoV-2 SARS-CoV2 serine protease inhibitors sphingosine SphK2 inhibitors stages target the cell the disease therapeutic intervention triggered vaccination variants Viral viral entry viral genome viral infection Viral proteins virus
[DOI] 10.3390/molecules27030658 PMC 바로가기 [Article Type] Review

Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

개별 SARS-CoV-2 RNA 분자의 절대 정량은 감염 역학 및 변이체 차이에 대한 새로운 패러다임을 제공합니다

Research Article

Published on 2022-01-202022-09-10
Journal: eLife [Category] SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] B.1.1.7 B.1.1.7 variant cell population cells cellular clinical implications contributing to COVID-19 Degradation detection efficiency displaying early replication early stage early stages effort event exhibit genomes genomic RNA Human Infection mechanism nucleases positive provide quantification quantitation Replication replication kinetics Research RNA genome SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA molecule significantly single-molecule fluorescence in situ hybridisation smFISH subgenomic RNAs Transcription Transmissibility Transmission variant variant of concern Victoria Viral Viral proteins viral replication Viral RNA viral RNAs viral variant viruses
[DOI] 10.7554/eLife.74153 PMC 바로가기 [Article Type] Research Article

Construction of SARS-CoV-2 virus-like particles in plant

식물에서 SARS-CoV-2 바이러스 유사 입자의 구성

Article

Published on 2022-01-192022-09-10
Journal: Scientific Reports [Category] 치료법,

[키워드] acute respiratory syndrome coronavirus antigens approved caused construction coronavirus coronavirus 2 effort Emergency use immunogenicity IMPROVE membrane mutations non-infectious nucleocapsid pandemic Particle Plant biotechnology Plant sciences plants platform public health emergency purified Research respiratory S antigen S protein SARS-CoV-2 SARS-CoV-2 VLP sedimentation severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shape spikes sucrose sucrose cushion Vaccine Vaccine development Vaccines Viral protein Viral proteins Virus-like particle virus-like particles VLP VLPs
[DOI] 10.1038/s41598-022-04883-y PMC 바로가기 [Article Type] Article

Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses

Article

Published on 2022-01-182022-10-28
Journal: Viruses [Category] COVID-19, SARS,