Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro
Coronaviruses
[키워드] Acidic
acute respiratory syndrome
Affect
antiviral activity
Antiviral compound
approach
B.1.1.7
B.1.351
B.1.617.2
Beta
blocked
cathepsin L
caused
Cell
clinical virus isolates
Compound
Concentration
coronavirus
Coronavirus disease 2019
COVID-19
cysteine protease
Delta
effective
endocytosis
Endosomal acidification
enzymatic activity
expressing
furin
furin protease
global pandemic
hACE2
HIV
human Angiotensin-converting enzyme
human lung
in vitro
inhibit
intestinal cell
MCL-1
mechanisms
membrane fusion
Obatoclax
prevented
Protein
pseudotype
reducing
reporter
S protein
Safe
SARS-CoV-2
SARS-CoV-2 entry
SARS-CoV-2 spike
SARS-CoV-2 variant
set off
suggested
the SARS-CoV-2
Treatment
unmet need
virion
virus
virus entry
[DOI] 10.1080/22221751.2022.2026739 PMC 바로가기 [Article Type] Coronaviruses
[DOI] 10.1080/22221751.2022.2026739 PMC 바로가기 [Article Type] Coronaviruses