Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models세포 배양 기반 감염 모델에서 새로운 퀴놀린 화합물의 항 SARS-CoV-2 억제 프로필Article Published on 2022-01-192022-09-11 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] SARS, 치료제, [키워드] antiviral drug antiviral drug assessment Cell Cell culture cell culture-based infection models Compound compounds COVID-19 human SARS-CoV-2 Infection inhibitory Model morpholine morpholine-quinoline hybrids New pandemic profile quinoline quinoline compounds. SARS-CoV-2 SARS-CoV-2 infections selected Surveillance synthesis Vaccine Virological [DOI] 10.1002/chem.202103861 PMC 바로가기 [Article Type] Article
Identification and characterisation of SARS-CoV-2 and Human alphaherpesvirus 1 from a productive coinfection in a fatal COVID-19 case치명적인 COVID-19 사례에서 생산적인 동시 감염에서 SARS-CoV-2 및 인간 알파헤르페스바이러스 1의 식별 및 특성화Research Article Published on 2022-01-102022-09-10 Journal: Memórias do Instituto Oswaldo Cruz [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplicon-based sequencing Analysis approach can not causal relationship Chain Reaction characterisation Coinfection collected Coronaviridae coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity determine Diagnosis etiological agent explain fatal COVID-19 Genetic variant herpes simplex virus Herpes Simplex Virus 1 Herpesviridae high viral load HSV-1 Human identification Infection metagenomic Nasopharyngeal swab nasopharyngeal swab sample Neurological symptom Neurological symptoms neutralisation test outcome Patient PCR performed plaque Plaque assay plaque phenotypes polymerase chain polymerase chain reaction predominant reduction respiratory responsible reverse transcription reverse transcription real-time polymerase chain reaction RT-qPCR SARS-CoV-2 SARS-CoV-2 strain Sequencing severe symptom severe symptoms severity strain Strains suggested Support the disease Viral Viral load Virological virus [DOI] 10.1590/0074-02760210176 PMC 바로가기 [Article Type] Research Article
Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19광범위하게 중화하는 SARS-CoV-2 RBD 특이적 나노바디의 분무 전달은 COVID-19의 시리아 햄스터 모델에서 임상, 바이러스 및 병리학적 질병을 예방합니다Article Published on 2022-01-012022-09-11 Journal: mAbs [Category] 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin converting enzyme antibody binding site complementary Contact coronavirus COVID-19 disease effective enzyme in vitro in vivo Isolation Lung pathology molecular basis nanobody nebulized nebulized delivery neutralization Neutralizing neutralizing nanobody overlapping pandemic pilot study Prevent pseudoviruses RBD RBD mutations receptor Receptor binding Receptor-binding domain reductions in reported respiratory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudoviruses SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus single-domain antibody Support surface area the receptor-binding domain therapeutic Treatment unmet need variant Viral viral burden Virological weight loss [DOI] 10.1080/19420862.2022.2047144 PMC 바로가기 [Article Type] Article
Efficacy of systematic coronavirus screening by PCR and viral cultures in addition to triage in limiting the spread of SARS-CoV-2 within a hemodialysis unit혈액투석실 내에서 SARS-CoV-2의 확산을 제한하는 분류에 추가하여 PCR 및 바이러스 배양에 의한 체계적인 코로나바이러스 스크리닝의 효능Article Published on 2022-01-012022-09-11 Journal: Journal of Nephrology [Category] SARS, 치료기술, [키워드] acute respiratory syndrome addition Asymptomatic asymptomatic patients chronic Chronic hemodialysis Control Control and prevention coronavirus coronavirus 2 Culture cultures description detect effective Effectiveness Efficacy Epidemic ESRD exposure to Hemodialysis implementation individual infected patient infected patients Infection infection control intrinsic isolate limit marker measure Measures molecular test Molecular tests Patient patients PCR positive serology post-hoc Prevention strategy respiratory RT-PCR SARS-CoV-2 SARS-CoV-2 epidemic Screening screening strategy serology Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 shortening Spread symptomatic the epidemic the SARS-CoV-2 Triage viral culture Virological virus vulnerable population was performed were infected [DOI] 10.1007/s40620-021-01115-w PMC 바로가기 [Article Type] Article
SARS-CoV-2 N-antigenemia in critically ill adult COVID-19 patients: Frequency and association with inflammatory and tissue-damage biomarkers중증 성인 COVID-19 환자의 SARS-CoV-2 N-항원혈증: 염증 및 조직 손상 바이오마커와의 빈도 및 연관성Observational Study Published on 2022-01-012022-09-11 Journal: Journal of medical virology [Category] SARS, 바이오마커, 임상, 치료기술, 치료법, [키워드] 95% confidence interval absence adult COVID-19 patient antigenemia appear association Biomarker Biomarkers C-reactive protein Chain Reaction Clinical outcome Clinical severity Cohort collected COVID-19 COVID-19 patient Critically ill D-dimer ferritin ICU patient ICU Patients immunochromatography increased mortality Inflammation inflammation biomarkers Inflammatory Lactose lateral flow Logistic regression analysis median median age moderate Mortality Odds ratio parameter patients plasma Plasma levels polymerase chain polymerase chain reaction positive quantified quantitation recruited returned RNA RNA loads RT-PCR SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 N-antigenemia SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA SARS-CoV-2 RNAemia Serum level serum levels significantly higher specimen symptoms onset tracheal aspirate Tracheal aspirates Univariate logistic regression analysis Viral Virological were measured were used yielding [DOI] 10.1002/jmv.27300 PMC 바로가기 [Article Type] Observational Study
The virological impacts of SARS-CoV-2 D614G mutationSARS-CoV-2 D614G 돌연변이의 바이러스학적 영향Review Published on 2021-12-302022-09-11 Journal: Journal of Molecular Cell Biology [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aspartic acid caused Characteristics circulating contagious coronavirus coronavirus disease coronavirus diseases COVID-19 D614G D614G mutation D614G variant defined effective epidemiological Evolution glycine Impact Infection Infectivity Intensive mechanism mechanisms Mutation over pathogenicity position presenting prevalent produced RNA virus SARS-CoV-2 SARS-CoV-2 D614G severe acute respiratory syndrome Coronavirus single-stranded positive-sense spike glycoprotein variant Virological virus virus mutation virus transmission [DOI] 10.1093/jmcb/mjab045 PMC 바로가기 [Article Type] Review
Comparison of Plaque Size, Thermal Stability, and Replication Rate among SARS-CoV-2 Variants of ConcernCommunication Published on 2021-12-302022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Alpha antibody B.1.1.7 B.1.351 B.1.617.2 changes in Characteristics concern correlated COVID-19 pandemic demonstrated described effective Effectiveness evaluated Evolution exhibited Genetic management P.1 physiological physiological temperature plaque polymerase progeny Rate Replication Replication rate RNA viruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants stability therapeutic thermal thermal stability Transmissibility Vaccine variant variants of concern variants of interest Virological virological study viruses VoC VOCs [DOI] 10.3390/v14010055 PMC 바로가기 [Article Type] Communication
Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study초기 SARS-COV-2 환자에서 Molnupiravir의 최적 용량 및 안전성 : A 상 I, 오픈 라벨, 용량-에스calating, 무작위 대조 연구Randomized Controlled Trial Published on 2021-12-272022-08-13 Journal: Journal of Antimicrobial Chemotherapy [Category] MERS, SARS, 임상, [키워드] adaptive adult outpatients adverse event Bayesian Clinical research Control controls COVID-19 treatments dose enrolled evaluated facility greater group Mild molnupiravir objective Open-label optimal dose outcome Outpatient participant Patient PCR-confirmed pharmacokinetics phase platform Primary outcome Probability progression Randomized randomized controlled study randomized-controlled receiving responses Result Safe SARS-COV-2 infection screened secondary Secondary outcomes severe adverse events Standard-of-care symptom onset symptomatic infection Toxicity Trial Virological [DOI] 10.1093/jac/dkab318 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical, Virological, Immunological, and Genomic Characterization of Asymptomatic and Symptomatic Cases With SARS-CoV-2 Infection in India인도에서 SARS-CoV-2 감염이 있는 무증상 및 무증상 사례의 임상, 바이러스, 면역 및 게놈 특성 분석Cellular and Infection Microbiology Published on 2021-12-212022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis antibody Asymptomatic asymptomatic and symptomatic patients asymptomatic patients biochemical biochemical parameter Biochemical parameters C-reactive protein carried caused CD40L changes in characterization circulating antibodies circulating antibody clinical collected Comorbidities contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRP cytokine Cytokines D614G mutation determined by develop diabetes disease disease control disease severity effective Efficiency elevated ferritin genomic global pandemic hospitalized patient IFN-α2 IgA IgG IgM IL-1 IL-10 IL-15 IL-1α IL-6 IL-8 immunological implementation in viral India Infection IP-10 isolate Lactate lactate dehydrogenase LDH mDC Mutation no significant difference nucleocapsid protein Nucleocapsid proteins ORF1ab ORF3a ORF8 Oropharyngeal pathophysiology Patient plasma respiratory Result RT-PCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients serum serum sample serum samples Seven severe acute respiratory syndrome Coronavirus severe SARS severe SARS-CoV-2 SGOT SGPT Spike protein symptomatic Symptomatic patients treatment regimen two groups two patients type 2 diabete type 2 diabetes Viral viral infection Viral load viral strain viral strains Virological virus replication was determined were assessed Whole-genome sequence whole-genome sequencing [DOI] 10.3389/fcimb.2021.725035 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
COVID-19 surveillance systems in African countriesReview Published on 2021-12-192022-10-31 Journal: Health Promotion Perspectives [Category] COVID-19, [키워드] activity Africa African Algeria Angola conducted country COVID-19 data management diagnostic disease form global health Google Scholar health systems IDSR implementation Kenya Mauritius Mortality Nigeria Outbreaks pandemic peer-reviewed PubMed Central resource response responses resulting selected South Africa Surveillance Uganda Variation Virological [DOI] 10.34172/hpp.2021.49 PMC 바로가기 [Article Type] Review