Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants교차 중화 항체는 SARS-CoV-2 잠복 부위에 결합하고 순환 변이체에 저항합니다Article Published on 2021-09-272022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] affinity antibodies antibody Antibody therapeutics causative agent circulating SARS-CoV-2 variants circulating variant conserved COVID-19 COVID-19 pandemic cross-neutralizing antibody crystal structure crystal structures disrupt domain epitope Epitopes global effort global efforts isolates Mutation N-terminal domain neutralize Neutralizing antibodies public health RBD Receptor-binding domain recognize sarbecovirus SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants several variant several variants the RBD the receptor-binding domain Vaccines variants of SARS-CoV-2 Viral viral infection viral spike virus variants X-ray crystallography [DOI] 10.1038/s41467-021-25997-3 PMC 바로가기 [Article Type] Article
A Barcoded Flow Cytometric Assay to Explore the Antibody Responses Against SARS-CoV-2 Spike and Its VariantsSARS-CoV-2 스파이크 및 그 변이체에 대한 항체 반응을 조사하기 위한 바코드 유세포 분석 분석Immunology Published on 2021-09-232022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] accumulate Against Alpha Alpha variant B cell Beta Beta variant boost cell line characteristic chimeric color coronavirus COVID-19 COVID-19 patient COVID-19 patients E484K effort evaluate expressed expression Flow flow cytometric flow cytometry fusion protein generate Health Health crisis higher affinity human immune response human population humoral immune response Humoral immunity IgA class IgG IgG response Immune escape immune response less life-threatening lymphoma mutant Mutation N501Y Pneumonia Point mutation Protein protocol RBD receptor ACE2 receptor-binding domains reduce expression response S protein SARS-CoV-2 SARS-CoV-2 pandemic serum antibody severe disease manifestation spike Spike protein Spread spread to the patient the receptor-binding domain this new coronavirus vaccination variant variant of SARS-CoV-2 variants variants of SARS-CoV-2 Viral viral entry virus virus variants wild type WT S [DOI] 10.3389/fimmu.2021.730766 PMC 바로가기 [Article Type] Immunology
Shooting at a Moving Target—Effectiveness and Emerging Challenges for SARS-CoV-2 Vaccine DevelopmentReview Published on 2021-09-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] accelerate addressed adverse effects applied approval Breakthrough infection challenge clinical evaluation Compliance COVID-19 development Effectiveness Healthcare systems heterologous vaccination highlight Immune escape immunization implementation IMPROVE infected individual Infection Isolation Long COVID Mask measure mRNA vaccine normality Occurrence pandemic pathway positive powerful tool Prevent PROTECT restrict Safe SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 vaccine SARS-CoV-2 vaccines second generation vaccines severe COVID-19 Shooting Side effect social distancing Transmission Vaccination strategy Vaccine Vaccine development vaccine effectiveness vaccine safety Vaccines variants Variation Viral antigen virus transmission virus variant virus variants [DOI] 10.3390/vaccines9101052 PMC 바로가기 [Article Type] Review
Molecular evolutionary characteristics of SARS‐CoV‐2 emerging in the United StatesResearch Article Published on 2021-09-202022-10-04 Journal: Journal of medical virology [Category] SARS, 변종, 진단, [키워드] addition Amino acid beta coronavirus bioinformatics Bioinformatics analysis calculate Characteristics coding decrease Evolution Genome Health highly pathogenic Hypothesis medium molecular molecular evolution Mutation nonsynonymous mutation nucleotide Positive selection RNA viruses S gene S protein SARS‐CoV‐2 SARS‐CoV‐2 sequence Seven Spike protein statistically significant Surveillance the United State The United States virus virus variants was used were used whole genome whole genome sequence [DOI] 10.1002/jmv.27331 PMC 바로가기 [Article Type] Research Article
The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serumSARS-CoV-2 회복기 혈청의 중화 활성 및 RBD 결합에 대한 스파이크 N501Y 돌연변이의 영향Article Published on 2021-09-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] 95% CI Amino acid amino acids ANOVA Anti-RBD IgG Anti-S1 antibody Antibody binding assays B.1.1.7 B.1.351 binding binding domain clinician collected convalescent sera convalescent serum COVID-19 COVID-19 patient determine enzyme immunoassay evaluated geometric geometric mean geometric mean titer GMT Hong Kong IgG isolates K417N Lineage mean difference Michael microneutralization N501Y N501Y mutation neutralization Neutralizing activity neutralizing antibody Neutralizing antibody Spike protein receptor binding domain NSP2 one-way ANOVA Patient positive Protein RBD RBD binding Receptor binding Receptor binding domain recovered COVID-19 patient reduced Richard SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 lineage SARS-CoV-2 N501Y variant B.1.1.7 sensitivity sera serum service significantly spike Spike protein Spike receptor binding domain Spread statistically susceptibility symptom onset tested variant variants virus virus variant virus variants viruses VoC VOC. was determined wild-type [DOI] 10.1016/j.ebiom.2021.103544 PMC 바로가기 [Article Type] Article
Challenges at the host-arthropod-coronavirus interface and COVID-19: a One Health approachArticle Published on 2021-08-302023-06-22 Journal: Frontiers in bioscience (Landmark edition) [Category] 조류인플루엔자, [키워드] Arthropod COVID-19 Epidemiology Host immune response SARS-CoV-2 vaccination virus variants [DOI] 10.52586/4951
Case Report: Infection With SARS-CoV-2 in the Presence of High Levels of Vaccine-Induced Neutralizing Antibody ResponsesMedicine Published on 2021-07-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] antibody B.1 BNT162b2 Breakthrough infection Course healthcare worker highlight in vitro Infection Level measure mRNA vaccine mRNA vaccines Neutralizing Neutralizing antibodies Presence Protective replicated response responses SARS-CoV-2 upper respiratory tract vaccinated individuals vaccination virus virus variants [DOI] 10.3389/fmed.2021.704719 PMC 바로가기 [Article Type] Medicine
The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies단일 클론 항체 조합 REGEN-COV는 전임상 및 인간 연구에서 SARS-CoV-2 돌연변이 탈출로부터 보호합니다Clinical Trial Published on 2021-07-222022-09-11 Journal: Cell [Category] MERS, SARS, 변종, 임상, 진단, [키워드] antibody circulating variant circulating variants clinical setting clinically Combination combinations contribute Coverage COVID-19 COVID-19 patient dual escape global pandemic hamster imperative in vitro study in vivo investigated isolate monoclonal antibodies monoclonal antibody combination Monoclonal antibody treatments mutant PROTECT provide REGEN-COV SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 variant sequence Spike protein the spike protein therapeutic option Therapeutic treatment treated variant virus virus variant virus variants [DOI] 10.1016/j.cell.2021.06.002 PMC 바로가기 [Article Type] Clinical Trial
Efficacy of COVID-19 vaccines: From clinical trials to real life코로나19 백신의 효능: 임상시험부터 실생활까지Article Published on 2021-07-012022-09-11 Journal: Thérapie [Category] SARS, 변종, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition adenoviral vector adenoviral vectored vaccines clinical clinical development clinical trial clinical trials coronavirus Course COVID-19 COVID-19 pandemic demonstrated Effect Efficacy form globe immune response less mass vaccination Messenger RNA mitigate Mortality mRNA pandemic Phase I phase III trial public health question reduce SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread the disease vaccination Vaccine vectored vaccine virus virus variant virus variants [DOI] 10.1016/j.therap.2021.05.004 PMC 바로가기 [Article Type] Article
Development of SARS-CoV-2 Specific IgG and Virus-Neutralizing Antibodies after Infection with Variants of Concern or VaccinationArticle Published on 2021-06-252022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anti-N IgG Anti-RBD IgG anti-S IgG AstraZeneca avidity B.1.1.7 B.1.351 BNT162b2 ChAdOx1 concern contribute convalescent COVID-19 cVNT demonstrated detectable development domain Evidence examined humoral immune response Humoral immunity IgG immune response immunoblot Immunoglobulin increase in Infection Maturity Moderna mRNA-1273 neutralization Pfizer/BioNTech RBD reactivity robust SARS-CoV-2 SARS-COV-2 infection second dose sera Specific starting sVNT tested titer vaccination vaccine dose vaccinee vaccinees variants of concern viral spike virus variants virus-neutralizing antibodies virus-neutralizing antibody VoC was determined were used [DOI] 10.3390/vaccines9070700 PMC 바로가기 [Article Type] Article