Substitution at Aspartic Acid 1128 in the SARS Coronavirus Spike Glycoprotein Mediates Escape from a S2 Domain-Targeting Neutralizing Monoclonal AntibodyResearch Article Published on 2014-07-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid addition Alanine Amino acid antigenic bind binding Cell epitope escape etiological agent exhibited expression humans in vitro infect Infectious disease Interaction Lip mAb mAbs monoclonal antibody murine mutant Mutation neutralization Neutralizing neutralizing antibody no effect overcome Particles Prevent Protein pseudotyped residue respiratory S protein S2 subunit SARS-CoV SARS-CoV infection SARS-like CoV shown significant decrease SL-CoVs spike Substitution surface Spike the S protein viral entry virion virus wild-type wild-type virus zoonotic [DOI] 10.1371/journal.pone.0102415 PMC 바로가기 [Article Type] Research Article
Attenuation of Mouse Hepatitis Virus by Deletion of the LLRKxGxKG Region of Nsp1Research Article Published on 2013-04-082022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] attenuation C57BL/6 cells changes in conserved coronavirus Deletion different domain Gene Expression growth human diseases in vitro in vivo inhibited mechanism MHV MHV-A59 mice mouse mutant virus positive-sense promoters Region reporter Research responsible reverse genetic system RNA virus shown vaccinia virus was reduced were measured wild-type virus [DOI] 10.1371/journal.pone.0061166 PMC 바로가기 [Article Type] Research Article